Iyini i-hydroxypropyl methyl cellulose?

I-Hydroxypropyl methylcellulose(HPMC) iyi-polymer yokwenziwa esetshenziswa kabanzi ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla, izimonyo, nezokwakha. Iwuhlobo lwe-cellulose ether olukhiqizwa ukuguqulwa kwamakhemikhali e-cellulose yemvelo, okuyi-carbohydrate eyinkimbinkimbi etholakala ezitshalweni. I-HPMC iyinhlanganisela encibilikayo emanzini, engenaphunga, futhi enganambitheki enezinto eziningi eziyenza isebenziseke ezinhlobonhlobo zezinhlelo zokusebenza.

I-HPMC yakhiwe izingxenye ezimbili eziyinhloko: i-methyl cellulose (MC) ne-hydroxypropyl cellulose (HPC). I-MC iphuma ku-cellulose etholakala ngokuphendula i-cellulose nge-sodium hydroxide ne-methyl chloride. Le nqubo iphumela ekwengezweni kwamaqembu e-methyl kumgogodla we-cellulose, okuthuthukisa ukunyibilika kwawo emanzini. I-HPC, ngakolunye uhlangothi, iphuma ku-cellulose etholakala ngokuyiphendula nge-propylene oxide. Le nqubo iphumela ekwengezweni kwamaqembu e-hydroxypropyl kumgogodla we-cellulose, okuthuthukisa ngokwengeziwe ukuncibilika kwawo emanzini.

Inhlanganisela yalezi zingxenye ezimbili ku-HPMC iyinikeza izici eziyingqayizivele ezifana nokukhula kwe-viscosity, ukugcinwa kwamanzi okuthuthukisiwe, nokunamathela okuthuthukisiwe. Iphinde ibe nekhono lokwenza amajeli uma ixubene namanzi, okuyenza isebenziseke njenge-agent yokuqina ezimbonini eziningi.

Izicelo Zemithi ye-HPMC

Enye yezindlela eziyinhloko ezisetshenziswa ngayo i-HPMC kusembonini yezemithi, lapho isetshenziswa khona njengesamukeli ekwenziweni kwemikhiqizo ehlukahlukene yemithi. I-excipient into eyengezwa emkhiqizweni womuthi ukuze kube lula ukwenziwa kwawo, ukuwuphatha, noma ukumuncwa kwawo. I-HPMC ivamise ukusetshenziswa njenge-binder, disintegrant, and thickening ejenti ekwakhiweni kwamaphilisi, amaphilisi, kanye namanye amafomu omthamo oqinile.

Ekwakhiweni kwethebhulethi, i-HPMC isetshenziswa njengesihlanganisi ukuze kubanjwe isithako esisebenzayo nezinye izinto ezisizayo ndawonye. Iphinde isebenze njenge-disintegrant, esiza ithebhulethi ukuthi ihlukane lapho ihlangana namanzi noma olunye uketshezi lomzimba. I-HPMC iwusizo kakhulu njengesinqamuleli kumaphilisi enzelwe ukuthi agwinywe aphelele, njengoba evumela ithebhulethi ukuthi ihlukane ngokushesha futhi ikhulule isithako esisebenzayo.

I-HPMC iphinde isetshenziswe njenge-ejenti yokuqina kumafomu omthamo we-liquid afana nokumiswa, ama-emulsions, nama-gel. Ithuthukisa i-viscosity kanye nokuthungwa kwalezi zakhiwo, ezingathuthukisa ukuzinza kwazo kanye nokuphatha kalula. Ukwengeza, i-HPMC ingasetshenziswa njenge-ejenti yokukhululwa okuqhubekayo, evumela ukuthi umuthi ukhishwe kancane kancane esikhathini eside.

Izicelo Zokudla ze-HPMC

Embonini yokudla, i-HPMC isetshenziswa njenge-ejenti yokuqina, i-emulsifier, kanye ne-stabilizer. Ivame ukusetshenziswa kumasoso, okokugqoka, neminye imikhiqizo yokudla okuwuketshezi ukuze kuthuthukiswe ukuthungwa nokuzinza. I-HPMC ingasetshenziswa futhi njengesithako samafutha emikhiqizweni yokudla okunamafutha amancane, njengoba ingalingisa ukuthungwa namafutha omlomo ngaphandle kokwengeza ama-calories engeziwe.

Izicelo zezimonyo ze-HPMC

I-HPMC isetshenziswa futhi embonini yezimonyo njenge-ejenti yokuqina, i-emulsifier, ne-binder. Ivamise ukusetshenziswa kuma-lotions, okhilimu, neminye imikhiqizo yezimonyo ukuze kuthuthukiswe ukuthungwa kwazo nokuzinza. I-HPMC ingasetshenziswa futhi njenge-ejenti eyenza ifilimu, engathuthukisa ukunamathela nokumelana namanzi kwemikhiqizo yezimonyo.

Izicelo zokwakha ze-HPMC

Embonini yezokwakha, i-HPMC isetshenziswa njenge-ejenti yokuqina kanye ne-ejenti yokugcina amanzi ekwenziweni kukasimende nodaka. Ingathuthukisa ukusebenza kanye nokuvumelana kwalezi zakhiwo, okungathuthukisa ukusebenza kwazo nokuqina. I-HPMC ingasetshenziswa njenge-colloid evikelayo, engavimbela ukuhlangana kwezinhlayiya zikasimende futhi ithuthukise ukuhlakazeka kwazo.

Ukuphepha Nokulawula

I-HPMC ngokuvamile ibhekwa njengephephile ukuze isetshenziswe ekudleni, emikhiqizweni yezemithi, nasezinhlelweni. Icutshungulwe kabanzi ngokuphepha kwayo nobuthi, futhi ihlukaniswa njengento engeyona enobuthi, engeyona i-carcinogenic, kanye ne-non-mutagenic.

E-United States, i-HPMC ilawulwa yi-Food and Drug Administration (FDA) njengesengezo sokudla, kanye ne-United States Pharmacopeia (USP) njengesihlanganisi semithi. Iphinde iqondiswe ezinye izikhungo ezilawulayo emazweni ahlukene emhlabeni jikelele.

Ngaphandle kokuphepha kwayo, i-HPMC ingase ibangele izimpawu zesisu ezithambile ezifana nokuqunjelwa, ukuqunjelwa, kanye nesifo sohudo kwabanye abantu. Lezi zimpawu ngokuvamile zithambile futhi ziyazibekela umkhawulo, futhi zingagwenywa ngokudla i-HPMC ngokulinganisela.

Sengiphetha, i-hydroxypropyl methylcellulose (HPMC) iyi-polymer yokwenziwa eguquguqukayo futhi esetshenziswa kabanzi enezinto eziningi ezisetshenziswayo ezimbonini ezahlukahlukene. Izakhiwo zayo eziyingqayizivele, njengokukhuphuka kwe-viscosity, ukugcinwa kwamanzi okuthuthukisiwe, nokunamathela okuthuthukisiwe, kuyenza isebenziseke njenge-ejenti ejiyayo, i-emulsifier, i-stabilizer, kanye ne-binder emikhiqizweni yezemithi, yokudla, yezimonyo neyokwakha. I-HPMC ngokuvamile ibhekwa njengephephile futhi ilawulwa ama-ejensi ahlukahlukene alawulayo emhlabeni jikelele.