Iyini i-pH ye-HPMC?

I-HPMC (i-Hydroxypropyl Methylcellulose, i-hydroxypropyl methylcellulose) i-polymer encibilika emanzini esetshenziswa kabanzi ezimbonini zemithi, zokudla nezimonyo. Isetshenziswa kakhulu njenge-thickener, stabilizer, emulsifier, i-ejenti yokwakha ifilimu kanye ne-ejenti yokulawula. Khipha impahla. Isici saso esiyinhloko ukuthi singakha isixazululo esisobala emanzini futhi sinezakhiwo ezinhle zokuqina nokunamathela.

Inani le-pH le-HPMC
I-HPMC ngokwayo ayinalo inani le-pH eligxilile ngenxa yokuthi iyinto yepolymer engathathi hlangothi noma ene-acidic kancane. I-HPMC iwukuphuma kwe-nonionic cellulose, ngakho-ke ayishintshi kakhulu i-pH yesisombululo. Uma incibilika emanzini, i-pH yesixazululo ngokuvamile incike ku-pH yesincibilikizo ngokwaso kunezakhiwo zamakhemikhali zezinto ze-HPMC ngokwazo.

Ngokuvamile, i-pH yezixazululo ze-HPMC izohluka kuye nge-solvent. Ngokuvamile, i-pH yezixazululo ze-HPMC emanzini ahlanzekile cishe iphakathi kuka-6.0 no-8.0. Izinga lamanzi avela emithonjeni ehlukene, kanye namabanga ahlukene we-viscosity we-HPMC, kungase kuthinte kancane i-pH yesixazululo sokugcina. Uma kudingekile ukusebenzisa izixazululo ze-HPMC ngaphakathi kwebanga le-pH elithile, lokhu kungalungiswa ngokungeza amabhafa phakathi nenqubo yokuhlanganisa.

Umthelela wezakhiwo zomzimba namakhemikhali we-HPMC ku-pH
Njengoba i-HPMC iyinhlanganisela engeyona i-ionic futhi ingenawo amaqembu angahlukaniseki kuma-molecule ayo, ayithinti ngokuqondile i-pH yesixazululo njengama-polymers e-cationic noma anionic. Ukuziphatha kwe-HPMC esixazululweni kuthintwa ikakhulukazi izici ezifana nezinga lokushisa, ukugxilisa ingqondo, namandla e-ionic.

I-Viscosity kanye nokuzinza kwesixazululo: Ipharamitha eyinhloko ye-HPMC i-viscosity yayo, isisindo sayo samangqamuzana esinquma ukuthi iziphatha kanjani esixazululweni. I-pH yesisombululo se-HPMC esine-viscosity ephansi ingase isondele ku-pH yamanzi ngokwawo (imvamisa cishe ku-7.0), kuyilapho isixazululo se-HPMC esine-viscosity ephezulu singathambekela ekubeni ne-acidic kancane noma i-alkaline, kuye ngokuba khona kokungcola noma ezinye izithasiselo. esixazululweni. .

Umthelela wezinga lokushisa: I-viscosity yezixazululo ze-HPMC ishintsha nezinga lokushisa. Lapho izinga lokushisa likhuphuka, ukunyibilika kwe-HPMC kuyanda futhi i-viscosity iyancipha. Lolu shintsho aluthinti ngokuqondile i-pH yesisombululo, kodwa lungashintsha uketshezi nokuthungwa kwesixazululo.

Ukulungiswa kwe-pH ezimeni zohlelo lokusebenza
Kwezinye izinhlelo zokusebenza ezikhethekile, njengamasistimu okukhishwa alawulwayo emithi noma izithasiselo zokudla, kungase kube nezimfuneko ezithile ze-pH. Kulezi zimo, i-pH yesisombululo se-HPMC ingalungiswa ngokungeza izixazululo ze-asidi, isisekelo, noma sebhafa. Isibonelo, i-citric acid, i-phosphate buffer, njll. ingasetshenziswa ukulungisa i-pH yesisombululo se-HPMC ukuze kuqinisekiswe ukuzinza nokusebenza ngempumelelo komkhiqizo wokugcina.

Ezinhlelweni ze-HPMC ekwenziweni kwemithi, ukulawulwa kwe-pH kubaluleke kakhulu ngoba amazinga okuqedwa nokukhululwa kwezidakamizwa ngokuvamile ancike ku-pH yendawo. Imvelo engeyona i-ionic ye-HPMC iyenza ibonise ukuzinza okuhle kwamakhemikhali ezindaweni ezinamavelu e-pH ahlukene, okuyenza ifanelekele ukusetshenziswa kumaphilisi omlomo, amaphilisi, amalungiselelo e-ophthalmic kanye nemithi ye-topical.

Inani le-pH le-HPMC ngokwayo alinalo inani eligxilile. I-pH yayo incike kakhulu ohlelweni lwe-solvent nesisombululo esisetshenzisiwe. Ngokuvamile, i-pH yezixazululo ze-HPMC emanzini isukela cishe ku-6.0 kuya ku-8.0. Ezisetshenziswayo ezingokoqobo, uma i-pH yesisombululo se-HPMC idinga ukulungiswa, ingalungiswa ngokungeza i-buffer noma isisombululo se-acid-base.