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Yini edala ukuthi i-hydroxypropyl methylcellulose HPMC ithinte ukudluliselwa kokukhanya?

IHydroxypropylmethylcellulose (HPMC) iyi-polymer yokwenziwa esetshenziswa kabanzi etholakala emikhiqizweni eyahlukene okuhlanganisa izimonyo, imithi, upende nokudla. Yenziwa ngokushintsha i-cellulose ngokusabela kwamakhemikhali e-propylene oxide ne-methyl chloride. I-HPMC inezinto ezimbalwa ezifiselekayo, ezifana nokungewona ubuthi, okungacunuli, okubolayo, nokuhambisanayo. Enye yezinto zayo eziyingqayizivele yikhono layo lokuthinta ukudluliswa kokukhanya. Kulesi sihloko, sihlola izici ezihlukahlukene eziholela ku-HPMCs ezithinta ezokuthutha ezilula kanye nokusetshenziswa okungenzeka kwalesi sakhiwo.

Enye yezinto eziyinhloko ezithinta izakhiwo zokudlulisa ukukhanya kwe-HPMC ukwakheka kwayo kwamangqamuzana. I-HPMC iyi-polymer enamagatsha ehlanganiswe ne-cellulose namayunithi aphindayo e-methyl hydroxypropyl. Isisindo samangqamuzana e-HPMC sincike kuzinga layo lokushintsha (DS), isilinganiso senani le-hydroxypropyl namaqembu e-methyl ngeyunithi ngayinye ye-cellulose. I-HPMC ene-DS ephezulu inamaqembu e-hydroxypropyl kanye ne-methyl, okuholela esisindweni samangqamuzana esiphezulu kanye nomthelela obaluleke kakhulu ekudluliseni ukukhanya.

Esinye isici esibalulekile esithinta ukudluliswa kokukhanya ukugcwala kwe-HPMC esixazululweni. Lapho i-HPMC incibilika emanzini, kwakhiwa isisombululo esicacile nesisobala ezindaweni eziphansi. Njengoba ukugxila kukhula, isisombululo siba ne-viscous kakhudlwana futhi ukudlulisa kuncipha ngenxa yokusabalalisa ukukhanya. Ubukhulu balo mphumela buncike esisindweni samangqamuzana, i-DS kanye nezinga lokushisa lesixazululo.

Isici sesithathu esithinta ukudluliswa kokukhanya yi-pH yesisombululo. I-HPMC i-amphoteric polymer engakwazi ukusebenza njenge-asidi ebuthakathaka kanye nesisekelo esibuthakathaka, kuye nge-pH yesisombululo. Nge-pH ephansi, amaqembu e-hydroxypropyl kanye ne-methyl ku-HPMC aba yi-protonated, okuholela ekuncipheni kokuncibilika kanye nokuncipha kokudluliswa kokukhanya. Nge-pH ephezulu, umgogodla we-cellulose we-HPMC uyasuswa, okuholela ekwandeni kokuncibilika nokudluliswa kokukhanya.

Isici sesine esithinta ukudluliswa kokukhanya ukuba khona kwezinye izinhlanganisela ezifana nosawoti, ama-surfactants nama-co-solvents. Lezi zinhlanganisela zingasebenzisana ne-HPMC, zibangele izinguquko ekwakhekeni kwayo kwamangqamuzana nokuncibilika, ngaleyo ndlela kuthinte ukudluliswa kokukhanya. Isibonelo, ukufaka usawoti kungakhuphula amandla e-ionic esixazululo, okuholela ekuncipheni kokuncibilika kanye nokwanda kokuhlakazeka kokukhanya. Ngakolunye uhlangothi, ukuba khona kwama-surfactants kungashintsha ukungezwani kwendawo yesisombululo, okuholela ekwehleni kwe-viscosity kanye nokwanda kokudluliswa kokukhanya.

Izakhiwo zokudlulisa ukukhanya ze-HPMC zinezinhlelo zokusebenza ezihlukahlukene. Embonini yezemithi, i-HPMC isetshenziswa njenge-thickener, binder kanye ne-disintegrant kumaphilisi namaphilisi. Ikhono layo lokuthinta ukudluliswa kokukhanya likwenza kube usizo njengento yokumboza engavikela izithako ezisebenzayo ekonakalisweni okubangelwa ukukhanya. Izakhiwo ezihlakaza ukukhanya ze-HPMC futhi ziyenza ibe ikhandidethi elifanele lezinhlelo zokulethwa kwezidakamizwa ezilawulwayo ezidinga ukukhululwa okuqhubekayo kwezithako ezisebenzayo.

Ngaphezu kwemithi, izakhiwo zokudlulisa ukukhanya ze-HPMC nazo zisetshenziswa embonini yokudla. I-HPMC isetshenziswa esikhundleni samafutha ekudleni okunamafutha aphansi kanye nekhalori ephansi. Ikhono layo lokwenza amajeli e-viscous futhi azinzile ezixazululweni ezinamanzi alenza libe isithako esikahle semikhiqizo efana nezingubo zesaladi, imayonnaise namasoso. Izici ezihlakaza ukukhanya ze-HPMC zingasetshenziswa futhi ukudala ukubukeka okuguqubele eziphuzweni ezifana nejusi yezithelo neziphuzo zezemidlalo.

Kafushane, i-hydroxypropylmethylcellulose (HPMC) iyi-polymer yokwenziwa ebalulekile ngenxa yezakhiwo zayo ezihlukile, okuhlanganisa amandla okuthinta ukudluliswa kokukhanya. Izinto ezithinta ukudluliswa kokukhanya kwe-HPMC zifaka ukwakheka kwayo kwamangqamuzana, ukugxilisa ingqondo, i-pH, kanye nokuba khona kwezinye izinhlanganisela. Izakhiwo zokudlulisa ukukhanya ze-HPMC zinezicelo ezimbalwa ezingase zibe khona embonini yezemithi nokudla, okuhlanganisa ukulethwa kwezidakamizwa okulawulwayo nokudla okunamafutha amancane. Njengoba ucwaningo lwezakhiwo ze-HPMC luqhubeka, izicelo eziningi zingatholwa.


Isikhathi sokuthumela: Aug-02-2023
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