Indlela yokukhiqiza yokucwiliswa kwe-alkaline iyindlela evamile yokukhiqiza i-hydroxypropyl methyl cellulose (HPMC). Le ndlela ihilela ukusabela kwe-cellulose nge-sodium hydroxide (NaOH) bese kuba ne-propylene oxide (PO) ne-methyl chloride (MC) ngaphansi kwezimo ezithile.
Indlela yokucwiliswa kwe-alkaline inenzuzo yokukhiqiza i-HPMC enezinga eliphezulu lokushintshwa (DS), enquma izici zayo ezifana nokuncibilika, i-viscosity, kanye ne-gelation. Indlela ihlanganisa lezi zinyathelo ezilandelayo:
- Ukulungiswa kweCellulose
I-Cellulose itholakala emithonjeni yemvelo efana nokhuni, ukotini, noma ezinye izinto zezitshalo. I-cellulose iqale ihlanzwe bese iphathwa nge-NaOH ukuze kwakheke i-sodium cellulose, eyingxenye esebenzayo ekukhiqizeni i-HPMC.
- Ukusabela kweSodium Cellulose ngePropylene Oxide (PO)
I-sodium cellulose isuke isabela nge-PO phambi kwe-catalyst efana ne-tetramethylammonium hydroxide (TMAH) noma i-sodium hydroxide (NaOH) emazingeni okushisa aphezulu kanye nezingcindezi. Ukusabela kuholela ekwakhekeni kwe-hydroxypropyl cellulose (HPC).
- Ukusabela kwe-HPC nge-Methyl Chloride (MC)
I-HPC ibe isisabela ne-MC phambi kwe-catalyst efana ne-sodium hydroxide (NaOH) noma i-hydrochloric acid (HCl). Ukusabela kuphumela ekwakhekeni kwe-hydroxypropyl methyl cellulose (HPMC).
- Ukuwasha nokomisa
Ngemuva kokusabela, umkhiqizo ugezwa ngamanzi futhi womiswe ukuze uthole i-HPMC. Umkhiqizo uvamise ukuhlanzwa kusetshenziswa uchungechunge lwezinyathelo zokuhlunga kanye ne-centrifugation ukususa noma yikuphi ukungcola.
Indlela yokucwiliswa kwe-alkaline inezinzuzo ezimbalwa kunezinye izindlela, okuhlanganisa i-DS ephezulu nobumsulwa, izindleko eziphansi, nokuqina okulula. Indlela ingasetshenziswa futhi ukukhiqiza i-HPMC enezakhiwo ezahlukene ngokushintsha izimo zokusabela ezifana nezinga lokushisa, ingcindezi, nokugxilisa ingqondo.
Nokho, le ndlela inezinye izithiyo. Ukusetshenziswa kwe-NaOH ne-MC kungabeka izingozi zokuphepha nezemvelo, futhi inqubo yokukhiqiza ingadla isikhathi futhi idinga amandla amakhulu.
Sengiphetha, indlela yokukhiqiza yokucwiliswa kwe-alkali iyindlela esetshenziswa kabanzi yokukhiqiza i-HPMC. Indlela ihilela ukusabela kwe-cellulose nge-NaOH, PO, ne-MC ngaphansi kwezimo ezithile, okulandelwa ukuhlanzwa nokomiswa. Nakuba le ndlela inezinye izithiyo, izinzuzo zayo ziyenza ibe ukukhetha okuthandwayo ezimbonini nasezithakazelweni zemithi.
Isikhathi sokuthumela: Apr-23-2023