Ukunqunywa Okulula Kwekhwalithi Ye-Hydroxypropyl MethylCellulose

I-Hydroxypropyl Methylcellulose (HPMC) i-polymer evame ukusetshenziswa embonini yezemithi njenge-excipient noma njenge-ejenti enamathelayo yamaphilisi namaphilisi. Izinga le-HPMC linganqunywa ngamapharamitha ahlukahlukene, afana ne-viscosity, okuqukethwe komswakama, ukusabalalisa usayizi wezinhlayiyana, nobumsulwa.

Enye indlela elula yokunquma ikhwalithi ye-HPMC ngokulinganisa i-viscosity yayo. I-Viscosity isilinganiso sokumelana koketshezi nokugeleza, futhi ihlobene ngokuqondile nesisindo samangqamuzana e-HPMC. Isisindo samangqamuzana aphezulu i-HPMC izoba ne-viscosity ephakeme kune-HPMC ephansi yesisindo samangqamuzana. Ngakho-ke, ukuphakama kwe-viscosity ye-HPMC, ikhwalithi yayo ephezulu.

Enye ipharamitha ebalulekile okufanele icatshangelwe umswakama we-HPMC. Umswakama owedlulele ungaholela ekulimazeni kwe-HPMC, okunganciphisa ukusebenza kwayo. Ibanga elamukelekayo lokuqukethwe komswakama kwe-HPMC liyahlukahluka kuye ngokusetshenziswa okuhlosiwe, kodwa ngokuvamile kufanele libe ngaphansi kuka-7%.

Ukusatshalaliswa kosayizi wezinhlayiyana ze-HPMC nakho kuyisici esibalulekile ekunqumeni ikhwalithi yayo. I-HPMC enokusabalalisa kosayizi wezinhlayiyana ezincane iyakhethwa ngoba ivumela umkhiqizo ongaguquki futhi ofanayo. Ukusatshalaliswa kosayizi wezinhlayiyana kunganqunywa kusetshenziswa amasu ahlukahlukene njenge-laser diffraction noma i-microscopy.

Okokugcina, ukuhlanzeka kwe-HPMC kufanele nakho kuhlolwe. Ukuhlanzeka kwe-HPMC kunganqunywa ngokuhlaziya ukwakheka kwayo kwamakhemikhali kusetshenziswa amasu afana ne-high-performance liquid chromatography (HPLC) noma i-Fourier-transform infrared spectroscopy (FTIR). Ukungcola ku-HPMC kungathinta ukuphepha nokusebenza kwayo.

Sengiphetha, ikhwalithi ye-HPMC inganqunywa ngokulinganisa i-viscosity yayo, okuqukethwe komswakama, ukusatshalaliswa kosayizi wezinhlayiyana, nobumsulwa. Le mingcele ingahlolwa kalula kusetshenziswa amasu ahlukahlukene, futhi i-HPMC yekhwalithi ephezulu kufanele ibe ne-viscosity ephezulu, umswakama ophansi, ukusabalalisa usayizi wezinhlayiyana ezincane, kanye nokuhlanzeka okuphezulu.