Yenza ijeli ye-Hand Sanitizer usebenzisa i-HPMC ukuze ungene esikhundleni se-Carbomer
Ijeli yesanitizer yezandla isiyinto ebalulekile ekuphileni kwethu kwansuku zonke, ikakhulukazi phakathi nobhadane lwe-COVID-19. Isithako esisebenzayo kujeli yesanitizer yesandla ngokuvamile utshwala, obusebenza kahle ekubulaleni amagciwane namagciwane ezandleni. Kodwa-ke, ukwenza ukwakheka kwejeli, i-ejenti yokuqina iyadingeka ukuze udale ukufana okuzinzile okufana nejeli. I-Carbomer iyi-ejenti yokuqina evame ukusetshenziswa ekwakhiweni kwejeli ye-sanitizer yesandla, kepha kungaba nzima ukuyikhipha futhi ibone ukunyuka kwentengo ngenxa yalolu bhubhane. Kulesi sihloko, sizoxoxa ngendlela yokwenza ijeli yesanitizer yezandla usebenzisa iHydroxypropyl Methylcellulose (HPMC) esikhundleni se-carbomer.
IHydroxypropyl Methylcellulose (HPMC) iphuma ku-cellulose enezinhlobonhlobo zezinhlelo zokusebenza, okuhlanganisa njenge-thickener, binder, kanye ne-emulsifier. I-HPMC iyi-polymer encibilika emanzini engajiya ukwakheka okususelwe emanzini, ikwenze kube enye indlela efanelekile ye-carbomer esezandleni zejeli ye-sanitizer. I-HPMC itholakala kalula futhi ibiza kakhulu kune-carbomer, okuyenza ibe enye indlela ekhangayo kubakhiqizi.
Ukwenza ijeli yesanitizer yesandla usebenzisa i-HPMC, izithako ezilandelayo nemishini iyadingeka:
Izithako:
- I-Isopropyl alcohol (noma i-ethanol)
- I-hydrogen peroxide
- I-Glycerin
- IHydroxypropyl Methylcellulose (HPMC)
- Amanzi acwecwe
Izisetshenziswa:
- Isitsha sokuxuba
- Induku enyakazayo noma i-mixer kagesi
- Ukulinganisa izinkomishi nezinkezo
- pH imitha
- Isitsha sokugcina ijeli yesanitizer yesandla
Isinyathelo 1: Linganisa Izithako Kala izithako ezilandelayo:
- I-Isopropyl alcohol (noma i-ethanol): 75% wevolumu yokugcina
- I-hydrogen peroxide: 0.125% wevolumu yokugcina
- I-Glycerin: 1% yevolumu yokugcina
- I-HPMC: 0.5% wevolumu yokugcina
- Amanzi acwengekile: umthamo osele
Isibonelo, uma ufuna ukwenza u-100ml wejeli ye-sanitizer yesandla, uzodinga ukukala:
- I-Isopropyl alcohol (noma i-ethanol): 75ml
- I-hydrogen peroxide: 0.125ml
- I-Glycerin: 1 ml
- I-HPMC: 0.5ml
- Amanzi acwecwe: 23.375ml
Isinyathelo sesi-2: Hlanganisa Izithako Xuba i-isopropyl alcohol (noma i-ethanol), i-hydrogen peroxide, ne-glycerin ndawonye endishini yokuxuba. Hlanganisa ingxube ize ihlanganiswe kahle.
Isinyathelo sesi-3: Engeza i-HPMC Kancane kancane engeza i-HPMC kungxube ngenkathi ugqugquzela njalo. Kubalulekile ukwengeza i-HPMC kancane ukuze ugweme ukunqwabelana. Qhubeka ugqugquzela kuze kube yilapho i-HPMC isihlakazeke ngokuphelele futhi ingxube ibushelelezi.
Isinyathelo sesi-4: Engeza Amanzi Faka amanzi acwecwe engxubeni ngenkathi ugqugquzela njalo. Qhubeka ugqugquzela kuze kube yilapho ingxube isihlangene kahle.
Isinyathelo sesi-5: Hlola i-pH Hlola i-pH yengxube usebenzisa imitha ye-pH. I-pH kufanele ibe phakathi kuka-6.0 no-8.0. Uma i-pH iphansi kakhulu, engeza inani elincane le-sodium hydroxide (NaOH) ukuze ulungise i-pH.
Isinyathelo sesi-6: Hlanganisa Futhi Hlanganisa futhi ingxube ukuqinisekisa ukuthi zonke izithako zihlanganiswe ngokugcwele.
Isinyathelo sesi-7: Dlulisela Esitsheni Dlulisa ijeli yesanitizer yesandla esitsheni ukuze igcinwe.
Ijeli yesanitizer yesandla ewumphumela kufanele ibe nokuvumelana okubushelelezi, okufana nejeli okulula ukukusebenzisa ezandleni. I-HPMC isebenza njenge-thickener futhi idala ukuvumelana okuzinzile okufana nejeli, okufana ne-carbomer. Ijeli yesanitizer yesandla ewumphumela kufanele isebenze kahle ekubulaleni amagciwane namagciwane ezandleni, njengamajeli okuhlanza izandla atholakala ngokwentengiso.
I-manufacturing practices (GMP) iyisethi yezinkombandlela nezimiso eziqinisekisa ikhwalithi nokuphepha kwemikhiqizo yezemithi, okuhlanganisa ijeli yokuhlanza izandla. Le mihlahlandlela ihlanganisa izici ezihlukahlukene zenqubo yokukhiqiza, okuhlanganisa abasebenzi, izakhiwo, amathuluzi, imibhalo, ukukhiqizwa, ukulawulwa kwekhwalithi, nokusabalalisa.
Lapho ukhiqiza ijeli yesanitizer yesandla usebenzisa i-HPMC nanoma iyiphi enye i-ejenti yokujiya, kubalulekile ukulandela imihlahlandlela ye-GMP ukuze uqinisekise ikhwalithi nokuphepha komkhiqizo. Eminye imihlahlandlela ebalulekile ye-GMP okufanele ilandelwe lapho kwenziwa ijeli yesanitizer yesandla ihlanganisa:
- Abasebenzi: Bonke abasebenzi abathintekayo ohlelweni lokukhiqiza kufanele baqeqeshwe ngokufanele futhi bafanelekele izindima zabo. Kufanele futhi bazazi iziqondiso ze-GMP futhi bazilandele ngokuqinile.
- Izakhiwo: Indawo yokukhiqiza kufanele ihlanzeke, inakekelwe kahle, futhi yakhelwe ukuvimbela ukungcola. Indawo kufanele ifakwe umoya ofanele nokukhanyisa, futhi zonke izinto ezisetshenziswayo kufanele zilinganiswe ngendlela efanele futhi ziqinisekiswe.
- Izisetshenziswa: Zonke izinto ezisetshenziswa enqubweni yokukhiqiza kufanele zihlanzwe njalo futhi zigcinwe ukuze kuvinjelwe ukungcoliswa. Izisetshenziswa kufanele futhi ziqinisekiswe ukuze kuqinisekiswe ukuthi zisebenza ngendlela efanele futhi zikhiqiza imiphumela engaguquki.
- Amadokhumenti: Zonke izinqubo zokukhiqiza kufanele zibhalwe kahle, okuhlanganisa namarekhodi eqoqo, izinqubo ezijwayelekile zokusebenza (ama-SOP), namarekhodi okulawula ikhwalithi. Amadokhumenti kufanele aphelele futhi anembile ukuze kuqinisekiswe ukulandela umkhondo nokuziphendulela.
- Ukukhiqiza: Inqubo yokukhiqiza kufanele ilandele inqubo echaziwe futhi eqinisekisiwe eqinisekisa ikhwalithi engaguquki kanye nokuhlanzeka komkhiqizo. Zonke izinto ezisetshenziswa ohlelweni lokukhiqiza kufanele zikhonjwe kahle, ziqinisekiswe futhi zigcinwe.
- Ukulawulwa kwekhwalithi: Izinyathelo zokulawula ikhwalithi kufanele zibe khona ukuze kuqinisekiswe ukuthi umkhiqizo wokugcina uhlangabezana nemibandela edingekayo. Ukulawulwa kwekhwalithi kufanele kubandakanye ukuhlolwa kobunikazi, ubumsulwa, amandla, neminye imingcele efanele.
- Ukusatshalaliswa: Umkhiqizo oqediwe kufanele upakishwe kahle, ulebulwe, futhi ugcinwe ukuze uvimbele ukungcoliswa futhi ugcine ubuqotho bawo. Inqubo yokusabalalisa kufanele ibhalwe kahle, futhi konke ukuthunyelwa kufanele kulandelelwe kahle futhi kuqashelwe.
Ngokulandela lezi ziqondiso ze-GMP, abakhiqizi bangaqinisekisa ukuthi imikhiqizo yabo yejeli ye-sanitizer yezandla ingeyekhwalithi ephezulu futhi iphephile ukusetshenziswa. Le mihlahlandlela iphinde isize ekuqinisekiseni ukuvumelana nokuthembeka enqubweni yokukhiqiza, ebalulekile ukuze kuhlangatshezwane nesidingo esikhulayo sejeli ye-sanitizer yezandla ngesikhathi sodlame lwe-COVID-19.
Sengiphetha, i-Hydroxypropyl Methylcellulose (HPMC) ingasetshenziswa esikhundleni se-carbomer ekwakhiweni kwejeli ye-sanitizer yesandla. I-HPMC iyindlela engabizi kakhulu futhi etholakala kalula enganikeza izakhiwo zokujiya ezifanayo ku-carbomer. Lapho ukhiqiza ijeli yesanitizer yesandla usebenzisa i-HPMC, kubalulekile ukulandela imihlahlandlela ye-GMP ukuze uqinisekise ikhwalithi nokuphepha komkhiqizo. Ngokulandela le mihlahlandlela, abakhiqizi bangakhiqiza ijeli ye-sanitizer yesandla esebenza ngempumelelo ekubulaleni amagciwane namagciwane ezandleni, kuyilapho futhi beqinisekisa ukuphepha komsebenzisi wokugcina.
Isikhathi sokuthumela: Mar-18-2023