IHydroxypropyl methylcellulose isetshenziswa kumaphilisi

I-Hydroxypropyl methylcellulose (HPMC) iyisakhi esivamile esisetshenziswa emithini yemithi, kuhlanganisa namaphilisi. I-HPMC iyi-polymer esekelwe ku-cellulose encibilika emanzini futhi inezinhlobonhlobo zezakhiwo eziyenza isebenziseke ekwakhiweni kwethebhulethi. Lesi sihloko sizoxoxa ngezakhiwo ze-HPMC kanye nokusetshenziswa kwayo okuhlukahlukene ekukhiqizeni amathebulethi.

Izakhiwo ze-HPMC:

I-HPMC iyi-polymer eyi-hydrophilic engasetshenziswa njenge-binder, thickener, stabilizer, kanye ne-emulsifier. Inesisindo samangqamuzana aphezulu kanye nezinga eliphezulu lokushintshwa (DS), okuthinta ukunyibilika kwayo kanye nokubonakala kwayo. I-HPMC ingancibilika emanzini noma otshwaleni, kodwa ayincibiliki kuzincibilikisi eziningi eziphilayo. Futhi ayinabo ubuthi, ayicunuli, futhi ayiyona i-allergenic, okuyenza ibe ukukhetha okuhle kwezicelo zemithi.

Ukusetshenziswa kwe-HPMC kumathebulethi:

1. Isibopho:

I-HPMC ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi. Yengezwa kuma-tablet granules ukuze uwabambe ndawonye futhi uwavimbele ukuthi angaqhekeki. I-HPMC ingasetshenziswa iyodwa noma ihlanganiswe nezinye izibophezelo, njenge-microcrystalline cellulose (MCC), ukuthuthukisa ubulukhuni bethebhulethi kanye nokuthambile.

2. I-Disintegrant:

I-HPMC ingasetshenziswa futhi njenge-disintegrant ekwakhiweni kwethebhulethi. Ama-disintegrants afakwa kumaphilisi ukuze awasize ahlukane futhi ancibilike ngokushesha emgudwini wamathumbu. I-HPMC isebenza njengesibulala-magciwane ngokuvuvuka emanzini nokudala imigudu ukuze amanzi angene kuthebhulethi. Lokhu kusiza ukuhlukanisa ithebhulethi futhi kukhulule isithako esisebenzayo.

3. Ukukhishwa okulawulwayo:

I-HPMC isetshenziswa ekwenziweni kwethebulethi ekhishwe okulawulwayo ukuze kuqondiswe ukukhishwa kwesithako esisebenzayo. I-HPMC yenza isendlalelo sejeli ezungeze ithebhulethi, elawula ukukhishwa kwesithako esisebenzayo. Ugqinsi lwesendlalelo sejeli bungalawulwa ngokushintsha i-DS ye-HPMC, ethinta i-viscosity kanye nokuncibilika kwe-polymer.

4. Ukufakwa kwefilimu:

I-HPMC iphinde isetshenziswe njenge-ejenti yokuhlanganisa ifilimu ekwenziweni kwethebhulethi. Ukufakwa kwefilimu kuyinqubo yokufaka ungqimba oluncane lwe-polymer endaweni yethebhulethi ukuze kuthuthukiswe ukubukeka kwayo, ukuyivikela kumswakama, nokuvala ukunambitheka kwayo. I-HPMC ingasetshenziswa yodwa noma ihlanganiswe namanye ama-ejenti okugcoba ifilimu, njenge-polyethylene glycol (PEG), ukuthuthukisa izakhiwo zefilimu zokugqoka.

5. Umenzeli wokumiswa:

I-HPMC iphinde isetshenziswe njenge-ejenti yokumiswa ekwakhiweni koketshezi. Ingasetshenziselwa ukumisa izinhlayiya ezingancibiliki oketshezini ukuze udale ukumiswa okuzinzile. I-HPMC isebenza ngokwakha isendlalelo esivikelayo ezizungeze izinhlayiya, izivimbele ukuthi zingahlangani futhi zihlale phansi kwesiqukathi.

Isiphetho:

IHydroxypropyl methylcellulose iyi-polymer eguquguqukayo enezinhlobonhlobo zokusetshenziswa ekwakhiweni kwamathebhulethi. Ingasetshenziswa njenge-binder, i-disintegrant, i-ejenti yokukhishwa okulawulwayo, i-ejenti yokumboza ifilimu, ne-ejenti yokumiswa. Izakhiwo zayo ezingenabo ubuthi, ezingacasuli, nezingezona i-allergenic ziyenza ibe inketho efanelekile yezinhlelo zemithi. Izakhiwo ze-HPMC zingenziwa ngendlela efanele ngokushintsha izinga lokushintshwa, kuyenze ibe i-polymer eguquguqukayo engasetshenziswa ekuhlanganiseni okuhlukahlukene kwethebhulethi.