IHydroxypropylmethylcellulose (HPMC) iyi-polymer yokwenziwa etholakala ku-cellulose. Njenge-thickener, emulsifier kanye ne-stabilizer, isetshenziswa kakhulu ezimbonini zezokwelapha, zokudla nezimonyo. I-HPMC iphinde isetshenziswe ezintweni zokwakha ezifana usimende, udaka kanye negypsum ukuze kuthuthukiswe ukusebenza kanye nokugcinwa kwamanzi. Kulesi sihloko, sizoxoxa ngokukhiqizwa kwe-HPMC kanye nokusetshenziswa kwayo ezimbonini ezihlukahlukene.
Ukukhiqizwa kwe-HPMC
I-HPMC ihlanganiswa ngokuphendula i-cellulose nge-propylene oxide ne-methyl chloride ngaphansi kwezimo ze-alkaline. Inqubo ibandakanya lezi zinyathelo ezilandelayo:
Isinyathelo 1: Ukwelashwa kwe-alkaline kwe-cellulose
I-cellulose iphathwa ngesisombululo se-caustic se-sodium hydroxide ukuyiguqula ibe yi-alkaline cellulose. Lokhu kwelashwa kwenza amaqembu e-hydroxyl e-cellulose asebenze kakhulu, kube lula ukusabela okulandelayo.
Isinyathelo sesi-2: Ukusabela nge-Propylene Oxide
Esinyathelweni esilandelayo, i-propylene oxide yengezwa ku-cellulose ye-alkali ngaphansi kwezimo zokushisa ezilawulwayo nezingcindezi. Ukusabela kwenziwa phambi kwe-catalyst efana ne-amine ephakeme noma i-alkali metal hydroxide. I-Propylene oxide ihlangana namaqembu e-hydroxyl e-cellulose yakhe i-hydroxypropyl cellulose.
Isinyathelo sesi-3: I-Quaternization nge-Methyl Chloride
IHydroxypropylcellulose yabe isihlanganiswa ne-methyl chloride ukukhiqiza i-HPMC. Ukusabela kwenziwa ngaphansi kwezimo ze-alkaline, futhi izinga le-quaternization lingalawulwa ngokulungisa inani le-methyl chloride.
I-HPMC eyaba umphumela yagezwa, yahlungwa futhi yomiswa ukuze kutholwe impushana emhlophe, egeleza mahhala. Izakhiwo ze-HPMC, ezifana ne-viscosity, ukunyibilika, kanye nezakhiwo zejeli, zingashunwa ngokushintsha izinga lokushintshwa (DS) le-hydroxypropyl namaqembu e-methyl.
Ukusetshenziswa kwe-HPMC
I-HPMC inohlu olubanzi lwezicelo ezimbonini ezahlukahlukene. Ezinye izinhlelo zokusebenza eziphawulekayo kuxoxwa ngazo ngezansi:
Imboni yezemithi
I-HPMC isetshenziswa kabanzi embonini yezemithi njenge-thickener, binder kanye nefilimu yangaphambili. Isetshenziselwa ukwakhiwa kwethebhulethi ukulawula ukukhululwa kwezidakamizwa. I-HPMC isebenza njengesibophezelo ngokucindezela ingxube yempushana ibe ifomu lesilinganiso esiqinile. Iphinde ithuthukise ukunyibilika kanye nokutholakala kwe-bioavailability kwezidakamizwa ezingancibiliki kahle ngokwenza ukuhlakazeka okuzinzile nokufanayo.
imboni yokudla
I-HPMC isetshenziswa embonini yokudla njenge-emulsifier, i-thickener kanye ne-stabilizer. Ivame ukusetshenziswa emikhiqizweni yokubhaka, u-ayisikhilimu kanye nemikhiqizo yobisi. I-HPMC ithuthukisa ukuthungwa nokuvumelana kokudla ngokuvimbela ukuhlukaniswa kwezithako kanye nokunciphisa ukuhlangana. Iphinde ithuthukise ukunambitheka nempilo yeshelufu yokudla.
Imboni yezimonyo
I-HPMC isetshenziswa embonini yezimonyo njenge-thickener kanye ne-emulsifier. Isetshenziswa emikhiqizweni yokunakekelwa kwesikhumba nezinwele njengama-lotions, okhilimu, ama-shampoos nama-conditioner. I-HPMC ithuthukisa ukuthungwa nokuvumelana kwale mikhiqizo futhi inikeza izinzuzo zokuswakama kanye nezimo.
imboni yezokwakha
I-HPMC isetshenziswa embonini yezokwakha njengesengezo kusimende, udaka kanye negypsum. Ithuthukisa ukusebenza kanye nokugcinwa kwamanzi kwalezi zinto, ngaleyo ndlela kwandise amandla nokuqina kwazo. I-HPMC futhi yehlisa ingozi yokuqhekeka kanye nokuncipha ngesikhathi somiswa.
Ekuphetheni
Sengiphetha, i-HPMC iyi-polymer eguquguqukayo futhi eguquguqukayo esebenza ezimbonini ezahlukahlukene. Ilungiswa ngokwelashwa kwe-alkali ye-cellulose, ukusabela nge-propylene oxide, kanye ne-quaternization nge-methyl chloride. Izakhiwo ze-HPMC zingacushwa ngokushintsha izinga lokushintshwa. I-HPMC idlala indima ebalulekile embonini yemithi, yokudla, yezimonyo neyokwakha ngokuthuthukisa ukuthungwa, ukungaguquguquki nokusebenza kwemikhiqizo ehlukahlukene. Ukungabi nobuthi bayo kanye ne-biocompatibility kuyenza ibe isithako esiphephile nesibalulekile kulezi zimboni.
Isikhathi sokuthumela: Aug-03-2023