Izinto ezithinta i-viscosity ye-hydroxypropyl methylcellulose

IHydroxyl methyl cellulose (HPMC) iyi-polymer esetshenziswa kakhulu ezidakamizweni, kwizimonyo, ekudleni nakwezinye izimboni. Izici zayo eziyingqayizivele, ezifana ne-viscosity ephezulu, ikhono elihle lokuncibilika kwamanzi kanye ne-membrane, okwenza kube yingxenye ebalulekile kumafomula ahlukahlukene. I-viscosity iyisici esiyinhloko se-HPMC ekusebenziseni kwayo. I-viscosity ye-HPMC ithintwa izici ezihlukahlukene, njengokugxilisa ingqondo, izinga lokushisa, i-pH, nesisindo samangqamuzana. Ukuqonda izinto ezithinta i-viscosity ye-HPMC kubalulekile ekusebenzeni kahle. Lesi sihloko sidingida izinto ezithinta i-viscosity ye-hydroxylopyl methyl cellulose.

Gxila ku

Ukugxila kwe-HPMC kungenye yezinto ezibalulekile ezithinta i-viscosity yayo. I-viscosity yesisombululo se-HPMC iyanda ngokukhula kokugxila. Ezimweni eziphansi, iketango le-polymer ye-HPMC lihlakazeke kakhulu ku-solvent, ngakho-ke i-viscosity iphansi. Kodwa-ke, ekugxilweni okuphezulu, uchungechunge lwe-polymer luvame ukusebenzisana, okuholela ekubukeni okuphezulu. Ngakho-ke, i-viscosity ye-HPMC ilingana nokuhlushwa kwe-polymer. Ukugxila kuphinde kuthinte ukuziphatha kwe-gelization ye-HPMC. I-HPMC ene-high-concentration ingakha ijeli, ebaluleke kakhulu embonini yezemithi nokudla.

izinga lokushisa

Izinga lokushisa lingesinye isici esibalulekile esithinta i-viscosity ye-hydroxylopenyl cellulose. I-viscosity ye-HPMC iyancipha ngokunyuka kwezinga lokushisa. Iketango le-polymer le-HPMC liba nokugeleza okwengeziwe ezingeni lokushisa eliphakeme, okuholela ekubonakaleni okuphansi. Uma kuqhathaniswa nezixazululo zokugxila okuphezulu, umphumela wokushisa ku-viscosity ye-HPMC usobala kakhulu kusixazululo sokuhlushwa esiphansi. Ukwenyuka kwezinga lokushisa kuzophinde kuthinte ukunyibilika kwe-HPMC. Ezingeni lokushisa eliphezulu, ukuncibilika kwe-HPMC kuncipha, okuholela ekwehleni kwe-viscosity okubangelwa ukwehla kokuthandelwa kweketango.

pH

I-pH yesisombululo se-HPMC ingenye into ebalulekile ethinta i-viscosity yayo. I-HPMC iyi-polymer ene-asidi ebuthakathaka, ene-PKA engaba ngu-3.5. Ngakho-ke, i-viscosity yesisombululo se-HPMC iyazwela ku-pH yesisombululo. Ngaphansi kwevelu ye-pH ephakeme kune-PKA, iqembu likasawoti le-carboxylic acid le-polymer lalingaphansi kwe-protonization, okubangele ukuncibilika kwe-HPMC kukhuphuke, futhi i-viscosity yancipha ngenxa yokuncipha kwebhondi ye-hydrogen ye-interconsiscence yamangqamuzana. Ngaphansi kwenani le-pH elingaphansi kwe-PKA, iqembu le-carboxylic acid le-polymer laliyisisindo, elibangele ukuncibilika okuphansi kanye ne-viscosity ephezulu ebangelwa ukwanda kwebhondi ye-hydrogen. Ngakho-ke, inani le-pH elingcono kakhulu lesixazululo se-HPMC lincike ekusetshenzisweni okulindelekile.

Isisindo samangqamuzana

Isisindo samangqamuzana e-HPMC singenye into ebalulekile ethinta i-viscosity yayo. I-HPMC iyi-polymer polymer. Njengoba isisindo samangqamuzana e-polymer sikhula, i-viscosity yesisombululo se-HPMC izokhula. Lokhu kungenxa yokuthi iketango le-HPMC lesisindo samangqamuzana eliphakeme libambeke kakhulu, okuholela ekwandeni kwe-viscosity. Isisindo samangqamuzana e-polymer siphinde sithinte i-HPMC gelization. Ipolymer ye-HPMC maningi amathuba okuthi yenze amajeli kunamapholymeri anesisindo samangqamuzana aphansi.

Usawoti

Ukwengeza usawoti kusixazululo se-HPMC kungathinta kakhulu i-viscosity yayo. Usawoti uthinta amandla e-ion esixazululo se-HPMC, esishintsha ukusebenzisana kwama-polymer. Ngokuvamile, ukwengeza usawoti kusixazululo se-HPMC kuzobangela ukuba i-viscosity yehle. Lokhu kungenxa yokuthi amandla e-ion esixazululo ayancipha phakathi kwamandla amangqamuzana phakathi kweketango le-polymer ye-HPMC, ngaleyo ndlela kuncishiswe ukuncishiswa kokuphonswa kweketango, ngakho-ke i-viscosity iyancishiswa. Umphumela kasawoti ku-viscosity yesisombululo se-HPMC kuncike ohlotsheni kanye nokuhlushwa kukasawoti.

Ekuphetheni

I-viscosity ye-hydroxydal cibolin iyipharamitha eyinhloko ethinta ukusetshenziswa kwayo ezimbonini ezihlukahlukene. Izinto ezithinta i-viscosity ye-HPMC zihlanganisa ukugxila, izinga lokushisa, i-pH, isisindo samangqamuzana nosawoti. Ukuqonda lezi zici ku-viscosity ye-HPMC kubalulekile ukuze uthuthukise ukusetshenziswa kwayo ezinhlelweni ezihlukahlukene. Isixazululo se-HPMC singashintshwa ngokufanelekile ukuze kuzuzwe i-viscosity edingekayo eqondile.