Ukusetshenziswa kwe-Ethylcellulose Coating to Hydrophilic Matrices

I-Ethylcellulose (EC) iyi-polymer evame ukusetshenziswa embonini yezemithi ukuze kuhlanganiswe ukwakheka kwezidakamizwa. Kuyi-polymer ye-hydrophobic enganikeza umgoqo wokuvikela umuthi kumswakama, ukukhanya, nezinye izici zemvelo. I-EC coatings ingaphinda iguqule ukukhululwa komuthi ekwakhiweni, njengokuhlinzeka ngephrofayela yokukhishwa eqhubekayo.

I-Hydrophilic matrices iwuhlobo lokwakhiwa kwezidakamizwa eziqukethe ama-polymers ancibilikayo emanzini noma avuvukalayo, njenge-hydroxypropyl methylcellulose (HPMC). Lawa matrices angasetshenziswa ukuze anikeze ukukhululwa okulawulwayo komuthi, kodwa angase abe sengozini yokumuncwa amanzi kanye nokukhululwa kwezidakamizwa okulandelayo. Ukuze unqobe lo mkhawulo, izintambo ze-EC zingasetshenziswa ebusweni be-hydrophilic matrix ukuze kwakhe ungqimba oluvikelayo.

Ukusetshenziswa kwezingubo ze-EC kumatrices we-hydrophilic kunganikeza izinzuzo ezimbalwa. Okokuqala, i-EC coating ingasebenza njengesivimbeli somswakama ukuvikela i-matrix ye-hydrophilic ekuthathweni kwamanzi kanye nokukhululwa kwezidakamizwa okulandelayo. Okwesibili, i-EC coating ingashintsha ukukhululwa komuthi ku-hydrophilic matrix, njengokuhlinzeka ngephrofayela yokukhululwa eqhubekayo. Okokugcina, i-EC coating ingathuthukisa ukuzinza komzimba kokubunjwa, njengokuvimbela i-agglomeration noma ukunamathela kwezinhlayiya.

Ukusetshenziswa kwezingubo ze-EC kumatrices we-hydrophilic kungafezwa kusetshenziswa amasu okunamathela ahlukahlukene, afana ne-spray coating, i-fluid bed coating, noma i-pan coating. Ukukhethwa kwesu lokumboza kuncike ezintweni ezifana nezakhiwo zokwakheka, ukujiya okufunayo, kanye nesikali sokukhiqiza.

Kafushane, ukusetshenziswa kwezingubo ze-EC kumatrices e-hydrophilic kuyisu elivamile embonini yezemithi ukuze kulungiswe iphrofayili yokukhishwa nokuthuthukisa ukuzinza kokwakhiwa kwezidakamizwa.