Hydroxypropyl Methyl Cellulose (HPMC), izwi kandi nka hypromellose, ni polymer itandukanye, igice cya sintetike ya polymer ikoreshwa cyane mu nganda zitandukanye bitewe n’imiterere yihariye y’imiti n’umubiri. Nibikomoka kuri selile, aho amatsinda ya hydroxyl ya molekile ya selile asimburwa igice hamwe na mikorerexy (-OCH3) na hydroxypropyl (-CH2CHOHCH3). Iri hinduka ritanga HPMC hamwe nibintu byinshi byingirakamaro, bigira agaciro mubikorwa bya farumasi, ubwubatsi, ibiryo, ninganda zo kwisiga.
Imiterere yimiti nibyiza
HPMC ikomoka kuri selile, polymer nyinshi cyane, binyuze mumurongo wimiti. Inzira ikubiyemo kuvura selile hamwe na hydroxide ya sodium kugirango ikore alkali selile, hanyuma ikurikirwa na etherification hamwe na methyl chloride na oxyde ya propylene. Ibi bivamo gusimbuza amwe mumatsinda ya hydroxyl kumugongo wa selile hamwe na mikorobe na hydroxypropyl. Urwego rwo gusimbuza (DS) no gusimbuza umubyimba (MS) bigena imiterere nubushobozi bwibicuruzwa byanyuma. HPMC mubusanzwe ifite DS ya 1.8-2.0 na MS ya 0.1-0.2.
Ibyingenzi
Gukemura: HPMC irashobora gushonga mumazi akonje ariko ntigashonga mumazi ashyushye. Ikora gele iyo ishyushye, umutungo uzwi nka gelasique yumuriro, ushobora guhinduka nyuma yo gukonja. Ibi bituma bigira akamaro cyane mubisabwa aho ubushyuhe bushingiye ku bushyuhe bukenewe.
Viscosity: HPMC ibisubizo byerekana imyitwarire itari Newtonian, yogosha-kogosha, bivuze ko ububobere bwabo bugabanuka hamwe no kongera umuvuduko wogosha. Uyu mutungo ni mwiza muburyo busaba ibintu bigenzurwa neza, nk'irangi.
Ubushobozi bwo gukora firime: HPMC irashobora gukora firime zikomeye, zoroshye, kandi zibonerana, bigatuma iba firime nziza yahoze muri farumasi (kubitabo bisize) hamwe nibisabwa ibiryo.
Biocompatibilité n'umutekano: HPMC ntabwo ari uburozi, ntibitera uburakari, na biocompatible, ituma ikoreshwa mu miti, imiti yo kwisiga, n'ibiribwa bidafite ingaruka mbi ku buzima.
Porogaramu mu nganda zitandukanye
Inganda zimiti
HPMC ikoreshwa cyane mu nganda zimiti kubera imiterere yayo itandukanye:
Kugenzura Kurekura Kugenzura: HPMC ningingo yingenzi mugutegura ibinini bisohoka. Ubushobozi bwayo bwo kubyimba no gukora geli iyo uhuye na fluide gastrointestinal ituma irekurwa gahoro kandi igenzurwa nibikoresho bya farumasi bikora (APIs).
Ipitingi ya Tablet: Ubushobozi bwayo bwo gukora firime ikoreshwa mubisate by'amakoti, bitanga inzitizi yo gukingira ubushuhe, ogisijeni, n'umucyo, bityo bigatuma imiti ihagarara neza.
Umubyimba: HPMC ikora nk'umubyimba muburyo butandukanye bwamazi, nka sirupe nuguhagarika, byemeza guhuza no gutuza.
Inganda zubaka
Mu rwego rwubwubatsi, HPMC ikoreshwa mubicuruzwa nka:
Ibicuruzwa bishingiye kuri sima na gypsumu: HPMC itezimbere imikorere, kubika amazi, hamwe na adhesion ya sima na plastike ya gypsumu. Yongera igihe cyo gufungura, igabanya kugabanuka, kandi itezimbere ubworoherane no kurangiza ibikoresho byakoreshejwe.
Amatafari ya Tile: Itanga amazi meza cyane, ikongerera igihe cyakazi kandi igateza imbere imbaraga zo guhuza amatafari.
Inganda zikora ibiribwa
HPMC ikoreshwa nk'inyongera y'ibiryo (E464) kubikorwa bitandukanye:
Umubyimba no Kuringaniza Umukozi: Byakoreshejwe mu kubyimba no gutuza isosi, imyambarire, hamwe nisupu. Ubushobozi bwayo bwo gukora geles no guhagarika emulisiyo bifite agaciro cyane mubicuruzwa bitarimo amavuta make na gluten.
Ibikomoka ku bimera n'ibikomoka ku bimera: HPMC ikoreshwa mu gukora inyama n’amata y’amata, itanga imiterere n’umutekano ku bicuruzwa nk’inyama zishingiye ku bimera na foromaje idafite amata.
Inganda zo kwisiga
Mu kwisiga, HPMC ihabwa agaciro kubyo:
Kubyimba no Kwimura Ibintu: Ikoreshwa mumavuta, amavuta yo kwisiga, hamwe na shampo kugirango itange ibyifuzo byifuzwa kandi bitezimbere ituze rya emulisiyo.
Ubushobozi bwo gukora firime: HPMC ifasha gukora inzitizi irinda uruhu cyangwa umusatsi, byongera imikorere yibicuruzwa no kuramba.
Ibyiza n'imbibi
Ibyiza:
Guhinduranya: Ubushobozi bwa HPMC bwo gukora imirimo myinshi - kubyimba, gushushanya, gukora firime, gutuza - bituma bihinduka cyane.
Umutekano: Imiterere yacyo idafite uburozi, idatera uburakari ituma ikoreshwa neza mu biribwa, imiti, n'ibicuruzwa byita ku muntu.
Biodegradability: Kuba ikomoka kuri selile, HPMC ni biodegradable, ifitiye akamaro ibidukikije.
Imipaka:
Ibibazo byo gukemura: Mugihe HPMC ishonga mumazi akonje, irashobora gukora ibibyimba niba bidatatanye neza. Tekinike nibikoresho bikwiye birasabwa kugirango iseswa rimwe.
Igiciro: HPMC irashobora kubahenze ugereranije nizindi zibyibushye hamwe na stabilisateur, zishobora kugabanya imikoreshereze yabyo ikoresha ibiciro.
Biteganijwe ko icyifuzo cya HPMC kiziyongera kubera kwiyongera mu nganda zitandukanye, cyane cyane ko izamuka ry’ibicuruzwa birambye kandi bishingiye ku bimera. Udushya mubikorwa byumusaruro nuburyo bushya bushobora kurushaho kunoza imitungo no kwagura ibikorwa byacyo.
Ubushakashatsi n'Iterambere
Ubushakashatsi burimo gukorwa bwibanda ku kunoza imikorere ya HPMC binyuze mu guhindura imiti no kuvanga nizindi polymers. Iterambere mubikorwa byumusaruro rigamije kugabanya ibiciro ningaruka ku bidukikije, bigatuma HPMC ihitamo neza cyane mubikorwa bitandukanye.
Hydroxypropyl Methyl Cellulose (HPMC) ni polymer ikora cyane kandi ihuza n'imikorere hamwe nibikorwa byinshi mubikorwa bitandukanye. Imiterere yihariye nko kwikemurira ibibazo, kugenzura ubukonje, ubushobozi bwo gukora firime, numutekano bituma iba ingenzi muri farumasi, ubwubatsi, ibiryo, no kwisiga. Nubwo hari imbogamizi, ibyiza byayo hamwe nubushobozi bwo guhanga udushya bizaza ko HPMC izakomeza kugira uruhare runini mugutegura ibicuruzwa no guteza imbere inganda.
Igihe cyo kohereza: Gicurasi-24-2024