HPMC izabyimba mumazi?

Hydroxypropyl methylcellulose (HPMC) ni ether ya selile idafite selile ikozwe muri selile ikoresheje guhindura imiti. Nkibikoresho byingenzi byifashishwa na polymer, HPMC ikoreshwa cyane mubwubatsi, imiti, ibiryo, amavuta yo kwisiga nizindi nzego. Imyitwarire ya HPMC mumazi ningirakamaro cyane kuko igena ingaruka zikoreshwa mugukemura, harimo kubyimba, guhagarikwa, guhuza hamwe nubushobozi bwo gukora firime.

HPMC uburyo bwo kubyimba mumazi
HPMC izabyimba cyane mumazi. Uku kubyimba guterwa ahanini na hydrogen ihuza amatsinda ya hydroxyl na mikorobe ya mikorobe ya HPMC na molekile y'amazi. Iyo HPMC ihuye n’amazi, molekile zamazi zizinjira hagati yumurongo wurunigi rwa molekile ya HPMC, zisenya imigozi ya hydrogène hagati ya molekile, irambura ibice byumunyururu kandi yongere ubwinshi bwa molekile. Iyi nzira nicyo twita "kubyimba".

By'umwihariko, iyo HPMC yabyimbye mu mazi, ibanza gukuramo amazi igatangira kubyimba, hanyuma ikagenda ikora buhoro buhoro igisubizo cya colloidal. Iyi nzira ikubiyemo ibyiciro bibiri byingenzi: kimwe nicyiciro cyambere cyo kubyimba, ikindi nicyiciro cyakurikiyeho buhoro buhoro. Mu cyiciro cyambere, HPMC ikurura amazi kugirango ikore hydrates yabyimbye, inzira ikarangira muminota mike. Muri iki cyiciro, molekile zamazi zinjira vuba mubice bya HPMC, bigatuma ingano yazo yaguka. Mugihe amazi yinjiye kure, molekile ya HPMC igenda itandukana buhoro buhoro nuduce twinshi hanyuma ikinjira mubisubizo kugirango ibe igisubizo kimwe cyamazi.

Ibintu bigira ingaruka kubyimba HPMC mumazi

Ubushyuhe: Ubushyuhe bugira ingaruka zikomeye kumyitwarire ya HPMC mumazi. Muri rusange, uko ubushyuhe bwiyongera, umuvuduko wa HPMC wihuta kandi urwego rwo kubyimba rugaragara. Ni ukubera ko imbaraga za kinetic ya molekile zamazi ziyongera mubushyuhe bwinshi, bigatuma byoroha kwinjira mubice bya molekile ya HPMC no guteza imbere kwaguka. Nyamara, hejuru cyane ubushyuhe bushobora gutera kwangirika kwa HPMC kandi bikagira ingaruka kubiranga.

Icyiciro cya Viscosity: HPMC ifite amanota atandukanye ya viscosity. Iyo hejuru ya viscosity ya HPMC, niko igisubizo cya colloidal kiboneka cyane iyo cyabyimbye mumazi. Iyo HPMC ifite urwego rwo hejuru rwijimye rwabyimbye, molekile zamazi zinjira buhoro buhoro kandi inzira yo gusesa nayo ni ndende. HPMC ifite urwego rwo hasi rwijimye rworoshye gushonga kandi ikora igisubizo cyoroshye.

pH agaciro k'igisubizo: HPMC ifite imiterere ihuza n'agaciro ka pH. HPMC igira ingaruka nziza yo kubyimba mubihe bitagira aho bibogamiye cyangwa intege nke za aside. Mugihe cya acide ikomeye cyangwa alkaline ikomeye, imiterere ya molekuline ya HPMC irashobora guhinduka, bityo bikagira ingaruka kumyanya yo kubyimba no gusesa.

Kwishyira hamwe: Ubwinshi bwumuti wa HPMC mumazi nabyo bigira ingaruka kumyitwarire yabyo. Mugihe gito, HPMC iroroshye gushonga burundu no gukora igisubizo kimwe. Iyo yibanze cyane, imikoranire hagati ya molekile ya HPMC iriyongera, ibyo bikaba bishobora gutuma molekile zimwe na zimwe bigora gushonga burundu mumazi hanyuma bigakora gel.

Gushyira mubikorwa kubyimba HPMC
Ibibyimba bya HPMC bigira uruhare runini mubikorwa bifatika. Kurugero, muruganda rwa farumasi, HPMC ikoreshwa cyane mubisate biramba-bisohora. Kuberako yabyimbye mumazi kugirango ikore firime ya colloidal, irashobora kugenzura neza igipimo cyo kurekura ibiyobyabwenge, bityo bikongerera igihe ibiyobyabwenge.

Mu nganda zubwubatsi, HPMC ikoreshwa cyane mubyimbye kandi bigumana amazi ya sima nibikoresho bishingiye kuri gypsumu. Ibibyimba byayo birashobora kunoza guhuza no kubaka ibikoresho, mugihe kandi bigumana ubushuhe, bikongerera igihe cyo kugenera ibikoresho, kandi bikongerera imbaraga imashini hamwe nuburinganire bwibicuruzwa byarangiye.

Mu nganda z’ibiribwa n’amavuta yo kwisiga, HPMC nayo igira uruhare runini nkibyimbye na stabilisateur. Imyitwarire yacyo yo kubyimba irashobora guha ibiryo uburyohe nuburyo bwiza, mugihe kwisiga, HPMC ifasha gukora ingaruka imwe yo gukoresha no kugumana ubushuhe.

Imyitwarire yo kubyimba ya HPMC mumazi nigisubizo cyimikoranire hagati yimiterere yimiti na molekile zamazi. Muguhindura ibintu nkubushyuhe, agaciro ka pH, igipimo cyubwiza hamwe nubunini bwibisubizo, inzira yo kubyimba no gusesa ya HPMC mumazi irashobora kugenzurwa kugirango ihuze ibikenewe ahantu hatandukanye. Iyi mitungo yabyimbye ya HPMC ikoreshwa cyane munganda nyinshi, byerekana akamaro kayo nkibikoresho bya polymer bikora.