Ubukonje bwa HPMC ni ubuhe?

HPMC, cyangwa Hydroxypropyl Methylcellulose, ni polymer ya sintetike ikoreshwa cyane muri farumasi, ibiryo, kwisiga no kubaka. Ifite ibintu byinshi byiza cyane nko gukemura, gutuza, gukorera mu mucyo no gukora firime nkibibyimbye, bifata, firime yahoze, ihagarika agent na colloid ikingira.

Kubijyanye n'ubukonje bwa HPMC, ni igitekerezo gisa naho kitoroshye kuko ubukonje bugira ingaruka kubintu byinshi, nko kwibanda, uburemere bwa molekile, umusemburo, ubushyuhe nigipimo cyogosha.

Isano iri hagati yuburemere bwa molekuline nubukonje: Uburemere bwa molekuline ya HPMC nimwe mubintu byingenzi bigena ububobere bwayo. Muri rusange, uko uburemere bwa molekile burenze, niko ubwiza bwa HPMC. Kubwibyo, ababikora mubisanzwe batanga ibicuruzwa bya HPMC hamwe nuburemere butandukanye bwa molekile kugirango bahuze ibikenewe ninganda zitandukanye. Uburemere bwa molekuline busanzwe bugaragazwa nkigiciro cya K (nka K100, K200, nibindi). Ninini K agaciro, niko hejuru cyane.

Ingaruka zo kwibanda: Ubwiza bwumuti wa HPMC mumazi bwiyongera hamwe no kwiyongera kwinshi. Kurugero, 1% yibisubizo bya HPMC birashobora kugira ubwiza bwikubye inshuro nyinshi kurenza igisubizo cya 0.5%. Ibi bituma viscosity yumuti igenzurwa muguhindura concentration ya HPMC mubisabwa.

Ingaruka yumuti: HPMC irashobora gushonga mumazi cyangwa kumashanyarazi kama, ariko ibishishwa bitandukanye bigira ingaruka mubwiza bwayo. Mubisanzwe, HPMC ifite ubushobozi bwo gukemuka neza mumazi kandi ibisubizo byubwinshi bwumuti ni mwinshi, mugihe ibishishwa mumashanyarazi kama biratandukana bitewe na polarite yumuti hamwe nurwego rwo gusimbuza HPMC.

Ingaruka yubushyuhe: Ubukonje bwumuti wa HPMC burahinduka hamwe nubushyuhe. Mubisanzwe, ubwiza bwumuti wa HPMC buragabanuka iyo ubushyuhe bwiyongereye. Ni ukubera ko kwiyongera kwubushyuhe biganisha kuri molekile yihuta no kwiyongera kwamazi yumuti, bigabanya ubukonje.

Ingaruka yikigereranyo cyogosha: HPMC igisubizo ni amazi atari Newtonian, kandi ububobere bwayo burahinduka nigipimo cyogosha. Ibi bivuze ko mugihe cyo gukurura cyangwa kuvoma, viscosity ihinduka hamwe nuburemere bwibikorwa. Mubisanzwe, igisubizo cya HPMC cyerekana ubwogoshe bwogosha, ni ukuvuga ko ububobere bugabanuka kurwego rwo hejuru.

Amanota ya HPMC nibisobanuro: Ibyiciro bitandukanye byibicuruzwa bya HPMC nabyo bifite itandukaniro rikomeye mubwiza. Kurugero, igicuruzwa cyo hasi cya HPMC ibicuruzwa bishobora kugira ubukonje bwa mPas 20-100 kuri 2% yibanze, mugihe ibicuruzwa byo mu rwego rwo hejuru bya HPMC bishobora kuba bifite ubukana bwa mPas zigera ku 10,000-200.000.000. Kubwibyo, mugihe uhitamo HPMC, ni ngombwa guhitamo icyiciro cyiza cya viscosity ukurikije ibisabwa byihariye bisabwa.

Uburyo busanzwe bwo gupima: Ubukonje bwa HPMC mubusanzwe bupimwa na viscometero cyangwa rheometero. Uburyo bukoreshwa mubizamini burimo kuzenguruka viscometer na capillary viscometer. Imiterere yikizamini nkubushyuhe, kwibanda, ubwoko bwa solvent, nibindi birashobora kugira ingaruka zikomeye kubisubizo, bityo ibipimo bigomba kugenzurwa cyane mugihe cyo kwipimisha.

Ubukonje bwa HPMC nibintu bigoye bigerwaho nibintu byinshi, kandi guhinduka kwayo bituma ikoreshwa cyane mubikorwa bitandukanye. Haba mubiribwa, ibya farumasi, ibikoresho byubwubatsi cyangwa inganda zo kwisiga, gusobanukirwa no kugenzura ububobere bwa HPMC nikimwe mubintu byingenzi byerekana neza ibicuruzwa nibikorwa.