Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane munganda nka farumasi, ibiryo, nubwubatsi. Imikorere yayo iratandukanye ukurikije amanota yayo, atandukanye mubipimo nko kwijimye, urwego rwo gusimbuza, ingano y'ibice, n'ubuziranenge. Gusobanukirwa uburyo aya manota agira ingaruka kumikorere ningirakamaro mugutezimbere imikoreshereze yayo mubikorwa bitandukanye.
1. Kwishishanya
Viscosity nikintu gikomeye kigira ingaruka zikomeye kumikorere ya HPMC mubikorwa bitandukanye. Mubisanzwe bipimirwa muri centipoises (cP) kandi birashobora kuva hasi cyane kugeza hejuru cyane.
Imiti ya farumasi: Mubisobanuro bya tableti, HPMC ifite ubukana buke (urugero, 5-50 cP) ikoreshwa kenshi nka binder kuko itanga ibikoresho bihagije bifata bitagize ingaruka zikomeye kumwanya wo gusenyuka. HPMC-yuzuye cyane (urugero, 1000-4000 cP), kurundi ruhande, ikoreshwa mugutegekwa-kurekura. Ubukonje bwinshi butinda umuvuduko wo kurekura ibiyobyabwenge, bityo bikagura imiti neza.
Ubwubatsi: Mubicuruzwa bishingiye kuri sima, hagati ya HPMC yo hagati (hejuru, 100-200.000 cP) ikoreshwa mukuzamura amazi no gukora neza. Urwego rwohejuru rwinshi rutanga amazi meza kandi rutezimbere hamwe nimbaraga zivanze, bigatuma biba byiza kumatafari na minisiteri.
2. Impamyabumenyi yo gusimburwa
Urwego rwo gusimbuza (DS) bivuga umubare wamatsinda ya hydroxyl kuri molekile ya selile yasimbujwe na mikorobe cyangwa hydroxypropyl. Ihinduka rihindura ibisubizo, gelation, hamwe nubushyuhe bwa HPMC.
Gukemura: Indangagaciro za DS zisanzwe zongera amazi. Kurugero, HPMC ifite vitamine yo hejuru irashonga byoroshye mumazi akonje, bigira akamaro muguhagarika imiti na sirupe aho bikenewe vuba.
Ubushyuhe bwa Thermal: DS nayo igira ingaruka kubushyuhe bwa gelation. HPMC ifite urwego rwo hejuru rwo gusimbuza ubusanzwe geles ku bushyuhe buke, ibyo bikaba byiza mugukoresha ibiryo aho bishobora gukoreshwa mugukora ubushyuhe butajegajega. Ibinyuranye, DS HPMC yo hepfo ikoreshwa mubisabwa bisaba ubushyuhe buhanitse.
3. Ingano y'ibice
Ingano yubunini igabanya ingaruka zo guseswa nibintu bifatika byibicuruzwa byanyuma.
Imiti ya farumasi: Ingano ntoya HPMC irashonga vuba, bigatuma ikwirakwizwa vuba-vuba. Ibinyuranye, ingano nini nini ikoreshwa mubinini bigenzurwa-kurekura, aho byifuzwa gusesa buhoro kugirango byongere ibiyobyabwenge.
Ubwubatsi: Mubikorwa byubwubatsi, uduce duto twa HPMC tunoza uburinganire nuburinganire bwimvange. Ibi nibyingenzi kugirango habeho guhuza amarangi, amarangi, hamwe nibifatika.
4. Isuku
Isuku ya HPMC, cyane cyane kubijyanye no kuba hari ibihumanya nkibyuma biremereye hamwe n’ibisigara bisigaye, ni ingenzi cyane cyane mu miti no gukoresha ibiryo.
Imiti n'ibiribwa: amanota meza-ya HPMC ni ngombwa kugirango yuzuze ibipimo ngenderwaho no kurinda umutekano. Umwanda urashobora kugira ingaruka kumikorere ya polymer kandi bigatera ingaruka kubuzima. Imiti yo mu rwego rwa farumasi HPMC igomba kubahiriza amabwiriza akomeye nkayasobanuwe muri farumasi (USP, EP) kubanduza.
5. Gusaba-Imikorere yihariye
Gusaba imiti:
Binders and Fillers: Hasi kugeza hagati-ya-viscosity amanota ya HPMC (5-100 cP) akundwa nka binders hamwe nuwuzuza ibinini, aho bizamura imbaraga za mashini ya tablet bitabangamiye gusenyuka.
Kurekurwa kugenzurwa: amanota menshi ya HPMC (1000-4000 cP) nibyiza kugenzurwa-kurekura. Bakora inzitizi ya gel igenga irekurwa ryibiyobyabwenge.
Ophthalmic Solutions: Ultra-high-isuku, HPMC (munsi ya 5 cP) ikoreshwa mubitonyanga byamaso kugirango itange amavuta idateye uburakari.
Inganda zikora ibiribwa:
Inkoko hamwe na Stabilisateur: Icyiciro cyo hasi-giciriritse-cyiza cya HPMC (5-1000 cP) bikoreshwa mukubyimba no guhagarika ibicuruzwa byibiribwa. Batezimbere ubwiza nubuzima bwamasosi, imyambarire, nibikoni.
Indyo Yibiryo: HPMC ifite ubukonje bwinshi ikoreshwa nkinyongera ya fibre mubiribwa bya karori nkeya, itanga byinshi kandi bifasha igogorwa.
Inganda zubaka:
Ibicuruzwa bishingiye kuri sima na gypsumu: Hagati ya HPMC yo hagati cyane (100-200,000 cP) ikoreshwa mugutezimbere amazi, gukora, no gufatira hamwe. Ibi nibyingenzi mubisabwa nka tile yometseho, ibishushanyo, na plasteri.
Irangi hamwe na Coatings: amanota ya HPMC hamwe nubunini bukwiye hamwe nubunini bwibice byongera rheologiya, kuringaniza, hamwe no gutuza kwamabara, biganisha kumurangiza neza no kuramba.
Ibyiciro bitandukanye bya HPMC bitanga ibintu byinshi byumutungo ushobora guhuza ibikenewe mubikorwa bitandukanye. Guhitamo amanota-ashingiye ku bwenge, urwego rwo gusimbuza, ingano yingingo, nubuziranenge - bigira uruhare runini mugutezimbere imikorere kubikorwa byifuzwa. Mugusobanukirwa utu tuntu, ababikora barashobora guhitamo neza icyiciro cya HPMC kugirango bagere kubisubizo byiza, haba mubya farumasi, ibiryo, cyangwa ubwubatsi. Ubu buryo bwihariye butuma ibicuruzwa bikora neza, umutekano, nubuziranenge, bikerekana byinshi nakamaro ka HPMC mubikorwa byinganda.
Igihe cyo kohereza: Gicurasi-29-2024