Iyini i-hydroxypropyl methylcellulose efakwe endaweni ephansi?

I-Low-substituted hydroxypropylmethylcellulose (L-HPMC) iyi-polymer eguquguqukayo, eguquguqukayo esebenza ezimbonini ezahlukahlukene, okubandakanya ezamamithi, ezokudla, ezokwakha, nezimonyo. Le nhlanganisela isuselwa ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo. Ukuze uqonde i-hydroxypropyl methylcellulose efakwe endaweni ephansi, umuntu kufanele ahlukanise igama layo futhi ahlole izakhiwo zayo, ukusetshenziswa, ukuhlanganisa, kanye nomthelela ezimbonini ezahlukene.

1. Ukuqonda amagama:

I-Hydroxypropyl methylcellulose (HPMC):

I-Cellulose iyi-carbohydrate eyinkimbinkimbi eyakhiwe amayunithi e-glucose futhi iyingxenye eyinhloko yezindonga zamangqamuzana ezitshalo.

IHydroxypropyl methylcellulose iwuhlobo oluguquliwe lweselulosi olulashwe ngamakhemikhali ukuze lethule i-hydroxypropyl kanye namaqembu e-methyl. Lokhu kuguqulwa kuthuthukisa ukunyibilika kwayo nezinye izici ezifiselekayo.

Ukufaka esikhundleni okuphansi:

Isho idigri ephansi uma kuqhathaniswa nokuphuma kokunye okuphuma ku-cellulose, njengokuphuma kokunye okuthathelwe indawo kakhulu okufana ne-hydroxyethyl cellulose (HEC).

2. Ukusebenza:

Ukunyibilika:

I-L-HPMC incibilika kakhulu emanzini kune-cellulose.

I-Viscosity:

I-viscosity yezixazululo ze-L-HPMC ingalawulwa ngokulungisa izinga lokushintshwa, ikwenze ifanele uhla olubanzi lwezinhlelo zokusebenza.

Ukwakhiwa kwefilimu:

I-L-HPMC ingakha amafilimu amancanyana, iyenze ibe wusizo ezinhlelweni ezihlukahlukene zokuhlanganisa.

Ukuzinza kwe-thermal:

I-polymer ngokuvamile ibonisa ukuzinza okuhle kwe-thermal, okunomthelela ekuguquguqukeni kwayo ezinqubweni ezahlukene.

3. Ukuhlanganisa:

I-Etherification:

Ukuhlanganiswa kuhilela ukufakwa kwe-cellulose nge-propylene oxide ukwethula amaqembu e-hydroxypropyl.

I-methylation eyalandela ene-methyl chloride yengeza amaqembu e-methyl kumgogodla we-cellulose.

Izinga lokushintsha lingalawulwa ngesikhathi sokuhlanganiswa ukuze kutholwe izakhiwo ezifiselekayo.

4. Isicelo:

A. Imboni yezemithi:

Ama-binders nama-disintegrants:

Isetshenziswa njenge-binder ekwenziweni kwethebhulethi ukuhlanganisa izithako ndawonye.

Isebenza njenge-disintegrant ukukhuthaza ukuwohloka kwamaphilisi ohlelweni lokugaya ukudla.

Ukukhishwa okuzinzile:

I-L-HPMC isetshenziswa ekwakhiweni kokukhishwa okulawulwayo, okuvumela umuthi ukuthi ukhishwe kancane kancane ngokuhamba kwesikhathi.

Amalungiselelo ezihloko:

Itholakala kuma-creams, ama-gel namafutha okugcoba, inikeza i-viscosity futhi ithuthukisa ukusabalala kwamafomula.

B. Imboni yokudla:

I-Thickener:

Khulisa i-viscosity yokudla futhi ithuthukise ukuthungwa nokuzwakala komlomo.

isizinzisi:

Ithuthukisa ukuzinza kwama-emulsions nokumiswa.

Ukwakhiwa kwefilimu:

Amafilimu adliwayo okufaka ukudla.

C. Imboni yezokwakha:

Udaka nosimende:

Isetshenziswa njenge-ejenti yokugcina amanzi ezintweni ezisekelwe kusimende.

Thuthukisa ukusebenza kanye nokunamathela kokwakhiwa kodaka.

D. Izimonyo:

Imikhiqizo yokunakekelwa komuntu siqu:

Kutholakala kokhilimu, izinto zokugcoba kanye nama-shampoos ukusiza ukuthuthukisa ukuthungwa nokuzinza.

Isetshenziswa njenge-ejenti yokwenza ifilimu kuzimonyo.

5. Ukugada:

Igunyazwe yi-FDA:

I-L-HPMC ngokuvamile ibonwa njengephephile (GRAS) yi-US Food and Drug Administration (FDA).

Ukuhambisana nezindinganiso zokulawula kubalulekile ekusetshenzisweni kwayo kwezemithi nokudla.

6. Izinselele namathemba esikhathi esizayo:

I-Biodegradability:

Nakuba ama-polymer asekelwe ku-cellulose ngokuvamile ebhekwa njenge-biodegradable, izinga lokubola kwezinto eziphuma ku-cellulose eshintshiwe lidinga uphenyo olwengeziwe.

Ukusimama:

Ukutholakala okusimeme kwezinto zokusetshenziswa kanye nezindlela zokukhiqiza ezingayingeni imvelo yizindawo okusalokhu kugxilwe kuzo.

7. Isiphetho:

I-hydroxypropyl methylcellulose efakwe endaweni ephansi ibonisa ubuhlakani bokuguqulwa kwamakhemikhali ekusebenziseni izakhiwo zamapholymer emvelo. Ukusetshenziswa kwayo okuhlukahlukene ezimbonini ezahlukahlukene kugqamisa ukubaluleka kwayo ekukhiqizeni kwesimanje. Njengoba intuthuko yezobuchwepheshe nokusimama kuthatha indawo ephambili, ukuhlola okuqhubekayo nokwenziwa ngcono kwe-L-HPMC nezinhlanganisela ezifanayo kungase kulolonge ikusasa lesayensi yezinto ezibonakalayo kanye nezinqubo zemboni.