IHydroxypropyl methylcellulose (HPMC) iyisengezo esisebenza ngezindlela eziningi esisetshenziswa kakhulu embonini yezokwakha, ikakhulukazi ekwakhekeni kodaka lwengxube eyomile. Le nhlanganisela ingeyomndeni we-cellulose ether futhi itholakala ku-cellulose yemvelo. I-HPMC ihlanganiswa ngokwelapha i-cellulose nge-propylene oxide ne-methyl chloride, okuholela ku-cellulose eguquliwe enezakhiwo ezithuthukisiwe. Ukwengezwa kwe-HPMC ekwakhiweni kodaka lwengxube eyomile kunikeza izinto ezihlukahlukene ezifiselekayo, okuyenza ibe isithako esibalulekile ekwakhiweni kwezakhiwo nezakhiwo zesimanje.
Isakhiwo nokusebenza kwe-A.HPMC:
1.Isakhiwo samakhemikhali:
IHydroxypropylmethylcellulose inesakhiwo esiyinkimbinkimbi esiqukethe izingxenye ze-hydrophilic kanye ne-hydrophobic. Amaqembu e-hydroxypropyl kanye ne-methyl ethulwe ngesikhathi sokuhlanganiswa anikeza izakhiwo ezithile ze-molecule.
2. Ukuncibilika kwamanzi:
I-HPMC ayincibiliki emanzini, eyivumela ukuthi incibilike emanzini abandayo ukuze yakhe isixazululo esicacile nesibonakalayo. Lesi sakhiwo sibalulekile ekufakweni kodaka lwengxube eyomile njengoba iqinisekisa ukuhlakazeka okufanele kanye nokufana kwengxube yokugcina.
3. I-Thermal Gelation:
I-HPMC ingena kunqubo ye-thermogelling ehlehliswayo, okusho ukuthi ingakha ijeli uma ishisisiwe futhi ibuyele kusixazululo uma isipholile. Lokhu kuziphatha kusiza ukuthuthukisa ukugcinwa kwamanzi nokusebenza kwengxube yodaka.
4. Ikhono lokwenza ifilimu:
I-HPMC inezinto zokwakha ifilimu futhi yenza ifilimu evikelayo ebusweni bezinhlayiya zodaka. Ifilimu ithuthukisa ukunamathela, inciphisa uthuli, futhi ithuthukise ukuqina okuphelele kodaka.
B. Iqhaza le-HPMC kudaka olomile oluxubile:
1. Ukugcinwa kwamanzi:
Omunye wemisebenzi esemqoka ye-HPMC odakeni lwengxube eyomile ukuthuthukisa ukugcinwa kwamanzi. Imvelo ye-hydrophilic ye-molecule ye-HPMC iyivumela ukuthi imunce futhi igcine umswakama, ivimbela udaka ukuthi lome ngaphambi kwesikhathi. Lokhu kubalulekile ekusebenzeni isikhathi eside kanye nokwelashwa okulungile kodaka.
2. Thuthukisa ukusebenza:
Ukwengeza i-HPMC ekwenziweni kodaka lwengxube eyomile kuthuthukisa ukusebenza nokuvumelana. Isiza ukufeza ukusetshenziswa kodaka olubushelelezi, okwenza kube lula ukuphatha nokubeka.
3. Yehlisa ukuwohloka:
I-HPMC isiza ekumelaneni nokuntenga kodaka, ukuyivimbela ekugoqeni noma ekuwohlokeni ezindaweni eziqondile. Lokhu kubaluleke kakhulu uma usebenza ezindaweni eziphakeme noma ezindongeni.
4. Thuthukisa ukunamathela:
Ikhono lokwenza ifilimu le-HPMC lisiza ukuthuthukisa ukunamathela phakathi kodaka nama-substrates ahlukahlukene. Lokhu kubalulekile ukuze kuzuzwe izibopho eziqinile nezihlala isikhathi eside ezinhlelweni zokwakha.
5. Umthelela wokusetha isikhathi:
Nakuba i-HPMC ingaphazamisi kakhulu isikhathi sokuqala sokusetha udaka, ingaba nomthelela kunqubo yonke yokugeleza kwamanzi futhi ibe nomthelela ekuthuthukisweni kwamandla esikhathi eside.
6. Ukuvumelana nezimo kanye nokumelana nokuqhekeka:
Ifilimu eyakhiwe yi-HPMC inika udaka ukuguquguquka, iyenze imelane nokuqhekeka. Lokhu kunenzuzo ikakhulukazi lapho ukunyakaza kwesakhiwo kungenzeka khona.
7. Ukuzinza ngaphansi kwezimo ezinzima:
I-HPMC inikeza udaka lwengxube eyomile ngokuzinza ngaphansi kwezimo zemvelo ezihlukahlukene, okuhlanganisa ukuchayeka ezimweni zezulu ezinzima. Ithuthukisa ukuqina nokusebenza jikelele kodaka.
C.Amanothi ohlelo lokusebenza:
1. Umthamo:
Inani elifanele le-HPMC lincike ezidingweni ezithile zengxube yodaka, okuhlanganisa izakhiwo ezifiselekayo nezimo zokusetshenziswa. Ukucatshangelwa nokuhlolwa ngokucophelela kubalulekile ekunqumeni umthamo ongcono kakhulu.
2. Ukuhambisana:
I-HPMC iyahambisana nezinhlobonhlobo zezinye izithasiselo nezithako ezivame ukusetshenziswa ekwenziweni kodaka lwengxube eyomile. Kodwa-ke, ukuhlolwa kokuhambisana kufanele kwenziwe ukuze kuqinisekiswe ukusebenza okudingekayo futhi kugwenywe noma yikuphi ukusebenzisana okubi.
3. Amazinga ekhwalithi:
Ikhwalithi ye-HPMC esetshenziswa odakeni lwengxube eyomile kufanele ihambisane namazinga emboni kanye nokucaciswa kwayo. Ukunamathela ezindinganisweni zekhwalithi kuqinisekisa ukusebenza kodaka okungaguquki nokuthembekile.
Ekuphetheni:
IHydroxypropyl methylcellulose (HPMC) iyisengezo esisebenza ngezindlela eziningi esidlala indima ebalulekile ekuthuthukiseni ukusebenza kodaka lwengxube eyomile. Inhlanganisela yayo eyingqayizivele yezakhiwo, okuhlanganisa ukugcinwa kwamanzi, ukusebenza okuthuthukisiwe kanye namakhono okwenza ifilimu, kuyenza ibe yingxenye ebalulekile yomkhuba wokwakha wesimanje. Njengoba izinto zokwakha ziqhubeka nokuguquguquka, ukusetshenziswa kwe-HPMC ekwakhekeni kodaka lwengxube eyomile kungasiza ukuthuthukisa izakhiwo ezihlala isikhathi eside, eziguquguqukayo nezisimeme.
Isikhathi sokuthumela: Dec-18-2023