Ukuhlolwa kwezimpawu zokulibaziseka kwe-hydration ze-hydroxypropyllylyll methylcellulose hpmc

I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-polymer esolulekayo esetshenziswa kabanzi ezintweni zokwakha, amakhemikhali, ukudla kanye nezimboni zamakhemikhali. I-HPMC inokuqina okuhle, ukugcinwa kwamanzi, izakhiwo ezenziwe ngefilimu nezibopho, futhi kubaluleke kakhulu ezintweni ezenzelwe amasimende ne-gypsum. Inqubo yokuqothula ye-Kimacell®HPMC ihlathinakele yizici eziningi, phakathi kwayo i-hydration ukubambezela isimilo iyisici esibalulekile, ikakhulukazi embonini yezokwakha, enquma ukusebenza kwezokwakha kanye nekhwalithi yokugcina yodaka, i-putty neminye imikhiqizo. Ngakho-ke, ukutadisha izici zokubambezeleka kwe-hpdration ze-HPMC kubaluleke kakhulu ekwakheni ukwakhiwa kwezinto ezibonakalayo.

1. I-HPMC hydration delay mechay

Ukuchithwa kwe-HPMC emanzini kubandakanya izigaba ezine: indawo ethambile, ukuhlakazeka kwezinhlayiya, ukuvuvukala kanye nokuchithwa. Lapho izinhlayiya ezijwayelekile ze-HPMC zithintana ngqo namanzi, ungqimba olungaphezulu luzodonsa amanzi ngokushesha ukuze kwakheke ungqimba lwejeli, oluvimbela ukuchithwa okuqhubekayo kwezinhlayiya zangaphakathi, ngaleyo ndlela kuboniswe into yokubambezeleka kwe-hydration. Ukuze uthuthukise ukusebenza kokwakha, eminye imikhiqizo ye-HPMC iphathwa ngokukhethekile, njengokuthezeka komhlaba noma ukwelashwa okuhlanganisiwe, ukuthuthukisa isikhathi se-hydration futhi uthuthukise isikhathi esivulekile nokusebenza ngesikhathi sokwakha.

Izici eziphambili ezithinta ukubambezeleka kwe-hydration zifaka:

Ukusatshalaliswa kosayizi wezinhlayiyana: Izinhlayiya ezinkulu zichithwa kancane kancane kunezinhlayiya ezincane, kanye nesikhathi sokulibaziseka kwe-hydration sekuyinto ende.

Ukwelashwa okungaphezulu: Amanye ama-HPMCS axhumene ngqo noma axhumene ne-hydrophobellically, angabambezela kakhulu i-hydration.

Ukushisa kwesisombululo: izinga lokushisa elikhulayo lingasheshisa ukuchithwa kwe-HPMC, kepha futhi lingathinti izici zokubambezeleka kwe-hydration ngaphakathi kwebanga elithile.

Uhlelo lwe-Solvent: Ama-electrolyte, ivelu ye-PH nezinye izengezo zingathinta izinga lokuchithwa kanye nesikhathi sokubambezeleka kwe-hpmc.

2. Design Design kanye nezindlela

2.1 Izinto zokuhlola

Amasampula we-HPMC (ama-viscosities ahlukile, izinhlobo ezahlukene zokwelashwa komhlaba)

Amanzi Ahlanganisiwe

Inselelo

I-Viscometer (efana ne-vescometer ejikelezayo)

I-Laser Particle Music Analyzer

2.2 Izinyathelo Zokuhlola

Ukunqunywa kwesikhathi sokulibala kwe-hydration

Ngaphansi kwezinga lokushisa elihlala njalo (25 ℃), inani elithile le-kimacell®HPMC lalifafazwe kancane emanzini ancishisiwe ngaphandle kokuvusa amanzi, futhi isikhathi esidingekayo sobuso be-gel ungqimba gelishle ngokuphelele.

Isilinganiso Sokuguqulwa Kwe-Viscosity

I-Vischosity yesixazululo yakalwa njalo ngemizuzu emi-5 isebenzisa i-veliccometer ejikelezayo ukuqopha ukuqedwa kwezimpawu zezinhlayiya ze-HPMC.

Ukuhlolwa kwe-solubility

ISampula yenziwa ngamaphuzu wesikhathi ahlukene, futhi izinhlayiya ezingalungiswa zahlukaniswa ngolwelwesi lokuhlunga ukunquma inkambiso ye-solubity ngokuhamba kwesikhathi.

Ukuhlaziywa kwezinhlayiyana

I-Laser Particle Music Usayizi Analyzer yayisetshenziselwa ukukala ushintsho ekusatshalalisweni kosayizi wezinhlayiya zezinhlayiya ze-HPMC ngesikhathi senqubo ye-hydration ukuhlola umphumela wokubambezeleka kwe-hydration.

3. Imiphumela yokuhlola nokuhlaziywa

Imiphumela yokuhlola ikhombisa ukuthi i-HPMC enesisulu esihlukile samamaki nezindlela zokwelashwa ezingaphezulu zinezimpawu ezihlukile zokubambezeleka kwe-hydration. I-HPMC ngaphandle kokwelashwa komhlaba ngokushesha yakha ungqimba lwejeli emanzini, kuyilapho i-HPMC enokwelashwa okukhethekile kwelashwa inesikhathi esibambezelekile kakhulu nge-hydration kanye nokuchithwa okufanayo okufanayo.

Umphumela wokuvunywa kokubambezeleka kwe-hydration

Izinhlayiya ze-HPMC eziphansi ze-HPMC zinesikhashana esifushane sokubambezeleka kwe-hydration ngenxa yesisindo sabo esincane samangqamuzana; I-High-Viscutity HPMC inesikhathi eside ukubambezeleka kwe-hydration ngenxa yesakhiwo sayo eside sama-molefanelar.

Umphumela wokwelashwa okungaphezulu kokubambezeleka kwe-hydration

Izinhlayiya ze-HPMC eziphathwe nge-hydrophobic coatic zinciphise ukungathathilwa kokuqala emanzini, futhi isikhathi sokulibaziseka kwe-hydration singanwetshwa imizuzu eyi-10-30.

Umphumela wokusatshalaliswa kosayizi wezinhlayiyana

Izinhlayiya ezinhle zinesikhathi esifushane sokulibaziseka kwe-hydration, ngenkathi izinhlayiya ezinkulu zinokubambezeleka okubaluleke kakhulu kwe-hydration ngenxa yethonya le-surce gel ungqimba.

Ukukhetha okunengqondo kweI-HPMCUngahlehlisa uhlelo lwayo ekwakheni nakwezinye izimboni, uthuthukise ukusebenza kokwakha kanye nokuqina ngokwezinto ezibonakalayo. Lolu cwaningo lunganikeza isisekelo sesayensi sokwenza kahle kwesicelo se-HPMC kanye nokuqondisa komkhiqizo kanye nokulungiswa kokwakheka