I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-cellulose esondelana yamanzi isetshenziswa kabanzi kumalungiselelo emithi, ikakhulukazi kumalungiselelo aqinile omlomo, amalungiselelo omlomo kanye namalungiselelo we-ophthalmic. Njenge-Execipieint ebalulekile ye-Pharmaceutical, i-KimaCell®HPMC inemisebenzi eminingi, efana nokunamathela, i-ejenti yokulawulwa kokukhishwa, njll. Amalungiselelo wezemithi, ngakho-ke kuthuthukisa ukusebenza kahle kwezidakamizwa, ngakho-ke kuthatha isikhundla esibalulekile ekuthuthukisweni kwamalungiselelo.
Izakhiwo ze-HPMC
I-HPMC iyi-ether ethe xaxa yamanzi noma ye-solvent-invula-inyumbazane etholwe ngokubuyisela ingxenye yamaqembu ama-hydroxyl kuma-molecule we-cellulose namaqembu we-methdypypropyly. Ine-soubity enhle nokuvunywa emanzini, futhi isixazululo sisobala noma sinethayela elincane. I-HPMC inokuqina okuhle kwezinto ezinjenge-PH yezemvelo kanye nezinguquko zokushisa, ngakho-ke kusetshenziswa kabanzi ekulungiseleleni izidakamizwa.
I-HPMC ine-biodegrade enhle epheshanangini lesisu, ukubabaza okuhle nokungabi nobuthi, futhi amalungiselelo awo akulula ukudala ukusabela komzimba, okwenza kuphephe ukuwasebenzisa emashashini emithi.
Ukusetshenziswa okuyinhloko kwe-HPMC kumalungiselelo emithi
Isicelo kumalungiselelo wokukhulula okuqhubekayo
I-HPMC isetshenziswa kabanzi kumalungiselelo wokukhulula okuqhubekayo, ikakhulukazi emalungiseleleni aqinile ngomlomo. I-HPMC ingalawula isilinganiso sokukhishwa kwezidakamizwa ngokusebenzisa isakhiwo senethiwekhi ye-gel IT. Emithini esondelana yamanzi, i-HPMC njenge-ejenti yokukhishwa okugciniwe ingabambezela isilinganiso sokukhishwa kwezidakamizwa, ngaleyo ndlela yandisa isikhathi sokusebenza kwezidakamizwa, ukunciphisa inani lezikhathi zokwenza izidakamizwa, kanye nokwenza ngcono ukulandelwa kweziguli.
Isimiso sesicelo se-HPMC kumalungiselelo wokukhulula okususelwa kususelwa kwi-solubility yakhe kanye nezindawo zokuvuvukala emanzini. Lapho amaphilisi noma ama-capsule angena ipheshana esiswini, i-HPMC ihlangana namanzi, imunca amanzi futhi ivuvukala ukwakha isendlalelo sejeli, esinganciphisa izidakamizwa. Izinga lokukhishwa kwezidakamizwa lingashintshwa ngokuya ngohlobo lwe-HPMC (efana namazinga ahlukene okufaka esikhundleni se-hydroxypropyl kanye namaqembu we-methyl) kanye nokuhlushwa kwawo.
Ama-beinders nama-ejenti akha amafilimu
Kumalungiselelo aqinile anjengamathebulethi, amaphilisi, kanye namagremu, i-HPMC njenge-binder ingathuthukisa ubunzima nobuqotho bamalungiselelo. Umphumela weBonding we-HPMC kulungiselelo awukwazi ukwenza kuphela izinhlayiya zezidakamizwa noma ama-powders abond
Njengomenzeli okha amafilimu, i-HPMC ingakha ifilimu efanayo futhi ivame ukusetshenziselwa ukunamathela kwezidakamizwa. Ngesikhathi senqubo yokulungiselela ukulungiswa, ifilimu le-kimacell®HPMC alikwazi ukuvikela kuphela isidakamizwa ethonyeni lendawo yangaphandle, kodwa futhi lilawule isilinganiso somuthi. Isibonelo, lapho kulungiswa amathebhulethi ahlanganiswe ngaphakathi, i-HPMC njengezinto ezihlanganayo kungavimba umuthi ukuthi ungakhishwe esiswini bese uqinisekisa ukuthi umuthi ukhishwa emathunjini.
I-ejenti ye-gelling kanye nesikhumuli
I-HPMC isetshenziswa kabanzi kumalungiselelo we-ophthalmic namanye amalungiselelo e-liquid njenge-ejenti ye-gelling. Ezidakamizweni ze-ophthalmic, i-HPMC ingasetshenziswa njengengxenye yokulahla izinyembezi ngezinyembezi zokufakelwa ukuze kuthuthukiswe isikhathi sokugcinwa kwesidakamizwa kanye nomphumela wokuthambisa kwamehlo, futhi kunciphise izinga lokuhwamuka kwamehlo. Ngaphezu kwalokho, i-HPMC ibuye ibe nezakhiwo eziqinile zokuqina, ezingakhulisa ukubonakala kokulungiswa kokuhlushwa okuthile, futhi kufanelekile ukuqina kwamalungiselelo ahlukahlukene.
Ekuhlelweni ngoketshezi ngomlomo, i-HPMC njengomuntu omkhulu ingathuthukisa ukuqina kokulungiselela, ivikele ukuhanjiswa kwemvula nokuhlukaniswa kwezinhlayiya, futhi kuthuthukise ukunambitheka nokubukeka.
Stabilizer for Oral Uketshezi
I-HPMC ingakha isixazululo esizinzile se-colloidal kumalungiselelo we-liquid, ngaleyo ndlela ithuthukise ukuqina kokulungiselela. Kungathuthukisa i-soubity kanye nokufana kwezidakamizwa kumalungiselelo we-liquid futhi kuvikele i-crystallization yezidakamizwa kanye nokuhamba kwezulu. Lapho ulungiselela ezinye izidakamizwa ezibolile futhi ezishabalalayo, ukungezwa kwe-HPMC kunganweba ngempumelelo impilo yeshede yezidakamizwa.
Njenge-emulsifier
I-HPMC nayo ingasetshenziswa njenge-emulsifier ukuze iqinise i-emulsion futhi isabalalisa umuthi lapho ulungiselela izidakamizwa zohlobo lwe-emulsion. Ngokulawula isisindo se-molecular kanye nokuhlushwa kwe-HPMC, ukuqina kanye nezinyoka ze-emulsion kungashintshwa ukuze kwenziwe kahle ngezindlela ezahlukahlukene zokulungiselela izidakamizwa.
Izinzuzo zesicelo se-HPMC
I-BiocomPity ephezulu kanye nokuphepha: I-HPMC, njenge-mourlose yemvelo etholwa, ine-biocomtic enhle, ayinangqondo futhi ayicasuli, ngakho-ke ilungele ukusetshenziswa kumalungiselelo wezidakamizwa.
Umsebenzi wokulawula ukukhishwa
Uhla olubanzi lwezicelo:I-HPMCIngasetshenziswa ezinhlobonhlobo zama-dosage amafomu afana namathebulethi, amaphilisi, ama-granule, kanye namalungiselelo woketshezi, ahlangabezana nezidingo zokulungiswa kwezidakamizwa ezahlukahlukene.
I-Hydroxypropylylylylykyl inenani elibalulekile lesicelo kumalungiselelo wezidakamizwa. Akunakusetshenziswa kuphela njenge-ejenti yokukhishwa okulondoloziwe, okunamathelayo, kanye ne-ejenti eyakha amafilimu, kepha futhi kube yi-siquner kanye ne-stabilizer kumalungiselelo owuketshezi. Izakhiwo zayo ezinhle kakhulu zomzimba nezamakhemikhali zikwenza kube ngenye ye-Excessients ebaluleke kakhulu embonini yezemithi, ikakhulukazi ekhombisa amandla amakhulu ekwenzeni ngcono ukuqina kwezidakamizwa kanye nokulawula isilinganiso sokukhishwa kwezidakamizwa. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezemithi, amathemba wesicelo seKimacell®HPMC azoqhubeka nokwandisa, ukuhlinzeka ukwesekwa kwamalungiselelo aphephile futhi asebenzayo.
Isikhathi Sokuposa: Jan-27-2025