Yintoni i-hydroxypropyl methyl cellulose?

IHydroxypropyl methylcellulose(HPMC) yipolymer eyenziweyo esetyenziswa kakhulu kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa, kunye nokwakha. Luhlobo lwe-ether ye-cellulose eveliswa yi-chemical modification ye-cellulose yendalo, eyi-carbohydrate eyinkimbinkimbi efumaneka kwizityalo. I-HPMC yikhompawundi enyibilikayo emanzini, engenavumba, nengenancasa eneempawu ezininzi ezenza kube luncedo kuluhlu lwezicelo.

I-HPMC yenziwe ngamacandelo amabini aphambili: i-methyl cellulose (MC) kunye ne-hydroxypropyl cellulose (HPC). I-MC yi-cellulose derivative efumaneka ngokuphendula i-cellulose kunye ne-sodium hydroxide kunye ne-methyl chloride. Le nkqubo ibangela ukongezwa kwamaqela e-methyl kwi-backbone ye-cellulose, ephucula ukunyibilika kwayo emanzini. I-HPC, kwelinye icala, i-derivative ye-cellulose efunyenwe ngokuyiphendula nge-propylene oxide. Le nkqubo ibangela ukongezwa kwamaqela e-hydroxypropyl kwi-cellulose backbone, ephucula ngakumbi ukunyibilika kwayo emanzini.

Indibaniselwano yala macandelo mabini kwi-HPMC ibonelela ngeepropati ezizodwa ezifana nokunyuka kwe-viscosity, ukugcinwa kwamanzi okuphuculweyo, kunye nokubambelela okuphuculweyo. Ikwanako nokwenza iijeli xa ixutywe namanzi, nto leyo eyenza ukuba ibe luncedo njengesixhobo sokutyebisa kumashishini amaninzi.

Usetyenziso lwezamayeza lwe-HPMC

Olunye lolona setyenziso luphambili lwe-HPMC kushishino loxubo-mayeza, apho lusetyenziswa njengoncedo ekuqulunqweni kweemveliso ezahlukeneyo zamachiza. I-excipient yinto eyongezwa kwimveliso yechiza ukwenza lula ukwenziwa kwayo, ulawulo, okanye ukufunxwa kwayo. I-HPMC iqhele ukusetyenziswa njenge-binder, i-disintegrant, kunye ne-arhente yokuqina ekuqulunqweni kweepilisi, ii-capsules, kunye nezinye iifom zedosi eqinileyo.

Kuqulunqo lwethebhulethi, i-HPMC isetyenziswa njengesibophelelo ukubamba isithako esisebenzayo kunye nezinye izincedisi kunye. Ikwasebenza njenge-disintegrant, enceda i-tablet ukuba ihlukane xa idibana namanzi okanye olunye ulwelo lomzimba. I-HPMC iluncedo ngokukodwa njenge-disintegrant kwiipilisi ezijoliswe ukuba ziginywe ziphelele, njengoko ivumela ithebhulethi ukuba ihlukane ngokukhawuleza kwaye ikhulule isithako esisebenzayo.

I-HPMC ikwasetyenziswa njenge-arhente etyebisayo kwiifom zedosi yolwelo ezifana nokunqunyanyiswa, i-emulsions, kunye neegels. Iphucula i-viscosity kunye nokuthungwa kwezi zakhiwo, ezinokuphucula ukuzinza kwazo kunye nokulula kolawulo. Ukongeza, i-HPMC ingasetyenziswa njenge-arhente yokukhutshwa okuzinzileyo, evumela ichiza ukuba likhutshwe ngokucothayo kwithuba elide lexesha.

Izicelo zokutya ze-HPMC

Kushishino lokutya, i-HPMC isetyenziswa njenge-ajenti etyebisayo, i-emulsifier, kunye ne-stabilizer. Idla ngokusetyenziswa kwiisosi, izambatho, kunye nezinye iimveliso zokutya ezingamanzi ukuphucula ukuthungwa nokuzinza kwazo. I-HPMC ingasetyenziswa njengokutshintsha kwamafutha kwiimveliso zokutya ezinamafutha aphantsi, njengoko inokulinganisa ukuthungwa kunye ne-mouthfeel yamafutha ngaphandle kokongeza iikhalori ezongezelelweyo.

Izicelo zokuthambisa ze-HPMC

I-HPMC ikwasetyenziswa kushishino lwezithambiso njenge-arhente etyebisayo, i-emulsifier, kunye ne-binder. Isetyenziswa ngokuqhelekileyo kwizinto zokuthambisa, iikhrimu, kunye nezinye iimveliso zokuthambisa ukuphucula ukuthungwa nokuzinza kwazo. I-HPMC ingasetyenziswa njenge-arhente yokwenza ifilimu, enokuphucula ukunamathela kunye nokumelana namanzi kwiimveliso zokuthambisa.

Izicelo zokwakha ze-HPMC

Kushishino lolwakhiwo, i-HPMC isetyenziswa njenge-arhente etyebisayo kunye ne-arhente yokugcina amanzi kwimixube yesamente kunye nodaka. Inokuphucula ukusebenza kunye nokuhambelana kwezi zakhiwo, ezinokuphucula ukusebenza kwazo kunye nokuqina. I-HPMC ingasetyenziswa njenge-colloid ekhuselayo, enokuthintela ukudityaniswa kwamasuntswana esamente kunye nokuphucula ukusasazeka kwabo.

Ukhuseleko kunye noLawulo

I-HPMC ithathwa njengekhuselekile ngokubanzi ekutyeni, kumayeza, nakwiimveliso zokuthambisa. Ifundwe ngokubanzi ngokukhuseleka kwayo kunye netyhefu, kwaye ihlelwa njengento engeyiyo ityhefu, i-non-carcinogenic, kunye ne-non-mutagenic substance.

EUnited States, i-HPMC ilawulwa yi-Food and Drug Administration (FDA) njengesongezo sokutya, kunye ne-United States Pharmacopeia (USP) njenge-excipient yamayeza. Ikwalawulwa zezinye ii-arhente ezilawulayo kumazwe ahlukeneyo kwihlabathi jikelele.

Ngaphandle kokhuseleko lwayo, i-HPMC inokubangela iimpawu ezincinci zesisu ezinjengokudumba, ukuqunjelwa, kunye norhudo kwabanye abantu. Ezi mpawu zihlala zithambile kwaye ziyazibekela umda, kwaye zinokuthintelwa ngokutya i-HPMC ngokumodareyitha.

Ukuqukumbela, i-hydroxypropyl methylcellulose (HPMC) yipolymer eyenziwe ngezinto ezininzi kwaye isetyenziswa ngokubanzi enezicelo ezininzi kumashishini ahlukeneyo. Iimpawu zayo ezizodwa, ezifana nokunyuka kwe-viscosity, ukugcinwa kwamanzi okuphuculweyo, kunye nokubambelela okuphuculweyo, kuyenza ibe luncedo njenge-ejenti yokuqina, i-emulsifier, i-stabilizer, kunye ne-binder kumayeza, ukutya, izimonyo kunye neemveliso zokwakha. I-HPMC ithathwa njengekhuselekile kwaye ilawulwa zii-arhente zolawulo ezahlukeneyo kwihlabathi jikelele.