Yintoni i-pH ye-HPMC?

I-HPMC (i-Hydroxypropyl Methylcellulose, i-hydroxypropyl methylcellulose) i-polymer e-soluble yamanzi esetyenziswa ngokubanzi kumashishini, ukutya kunye ne-cosmetic. Isetyenziswa kakhulu njenge-thickener, stabilizer, emulsifier, i-agent-forming agent kunye ne-agent yokulawula. Khupha imathiriyeli. Isici sayo esiphambili kukuba sinokwenza isisombululo esicacileyo emanzini kwaye sineempawu ezintle zokuqina kunye nokubambelela.

ixabiso pH of HPMC
I-HPMC ngokwayo ayinalo ixabiso le-pH elimiselweyo kuba liyinto engathathi hlangothi okanye eneasidi kancinane yepolima. I-HPMC yi-nonionic cellulose derivative, ngoko ayitshintshi kakhulu i-pH yesisombululo. Xa inyibilika emanzini, i-pH yesisombululo ngokuqhelekileyo ixhomekeke kwi-pH ye-solvent ngokwayo kuneempawu zekhemikhali zezinto ze-HPMC ngokwayo.

Ngokubanzi, i-pH yezisombululo ze-HPMC ziya kwahluka ngokuxhomekeke kwi-solvent. Ngokuqhelekileyo, i-pH yezisombululo ze-HPMC emanzini ahlambulukileyo iphakathi kwe-6.0 kunye ne-8.0. Umgangatho wamanzi avela kwimithombo eyahlukeneyo, kunye namabakala ahlukeneyo e-viscosity ye-HPMC, inokuchaphazela kancinci i-pH yesisombululo sokugqibela. Ukuba kuyimfuneko ukusebenzisa izisombululo ze-HPMC ngaphakathi koluhlu oluthile lwe-pH, oku kunokulungelelaniswa ngokudibanisa izithinteli ngexesha lenkqubo yokuqulunqwa.

Impembelelo yeempawu zomzimba kunye neekhemikhali ze-HPMC kwi-pH
Ekubeni i-HPMC iyikhompawundi engeyiyo i-ionic kwaye ayinayo amaqela e-dissociable kwiimolekyuli zayo, ayichaphazeli ngokuthe ngqo i-pH yesisombululo njengepolymers ye-cationic okanye i-anionic. Ukuziphatha kwe-HPMC kwisisombululo kuchaphazeleka ikakhulu zizinto ezifana nobushushu, ukugxila, kunye namandla e-ionic.

I-Viscosity kunye nozinzo lwesisombululo: Iparameter ephambili ye-HPMC yi-viscosity yayo, ubunzima bayo be-molecular echaza indlela eziphatha ngayo kwisisombululo. I-pH yesisombululo se-HPMC esine-viscosity ephantsi inokuba kufutshane ne-pH yamanzi ngokwawo (ngokuqhelekileyo ijikeleze i-7.0), ngelixa isisombululo se-HPMC esine-viscosity ephezulu sinokuthanda ukuba ne-acidic kancinane okanye i-alkaline, ngokuxhomekeke kubukho bobumdaka okanye ezinye izongezo. kwisisombululo. .

Impembelelo yobushushu: I-viscosity yezisombululo ze-HPMC iyatshintsha ngobushushu. Xa ubushushu bonyuka, ukunyibilika kwe-HPMC kwanda kwaye i-viscosity iyancipha. Olu tshintsho aluchaphazeli ngokuthe ngqo i-pH yesisombululo, kodwa lunokutshintsha umbane kunye nokuthungwa kwesisombululo.

ukulungiswa kwe-pH kwiimeko zesicelo
Kwezinye izicelo ezikhethekileyo, ezifana neenkqubo ezilawulwayo zokukhupha amayeza okanye izongezo zokutya, kunokubakho iimfuno ezithile ze-pH. Kwezi meko, i-pH yesisombululo se-HPMC inokulungelelaniswa ngokudibanisa i-asidi, isiseko, okanye izisombululo ze-buffer. Ngokomzekelo, i-citric acid, i-phosphate buffer, njl. ingasetyenziselwa ukulungisa i-pH yesisombululo se-HPMC ukuqinisekisa ukuzinza kunye nokusebenza kwemveliso yokugqibela.

Ukusetyenziswa kwe-HPMC ekuxutyweni kwamayeza, ulawulo lwe-pH lubaluleke kakhulu kuba amazinga okutshatyalaliswa kunye nokukhululwa kwamachiza ahlala exhomekeke kwi-pH yokusingqongileyo. Ubume be-HPMC be-non-ionic buyenza ibonise uzinzo oluhle lweekhemikhali kwiindawo ezinexabiso elahlukileyo le-pH, iyenza ilungele ukusetyenziswa kwiipilisi zomlomo, ii-capsules, amalungiselelo e-ophthalmic kunye ne-topical pharmaceuticals.

Ixabiso le-pH le-HPMC ngokwayo alinalo ixabiso elisisigxina. I-pH yayo ixhomekeke ngakumbi kwi-solvent kunye nenkqubo yesisombululo esetyenzisiweyo. Ngokuqhelekileyo, i-pH yezisombululo ze-HPMC emanzini isuka malunga ne-6.0 ukuya kwi-8.0. Kwizicelo ezisebenzayo, ukuba i-pH yesisombululo se-HPMC ifuna ukulungiswa, inokulungelelaniswa ngokongeza i-buffer okanye isisombululo se-acid-base.