IHydroxypropyl methylcellulose (HPMC) sisongezo esisebenza ngeendlela ezininzi esisetyenziswa kakhulu kushishino lolwakhiwo, ngakumbi kumxube owomileyo wokwenziwa kodaka. Le khompawundi yeyosapho lwe-cellulose ether kwaye ithathwe kwi-cellulose yendalo. I-HPMC idityaniswe ngokunyanga i-cellulose nge-propylene oxide kunye ne-methyl chloride, okukhokelela kwiselulosi elungisiweyo eneempawu eziphuculweyo. Ukongezwa kwe-HPMC kwimixube yodaka lwemixube eyomileyo inika iipropati ezahlukeneyo ezinqwenelekayo, iyenza ibe yinto ebalulekileyo ekwakhiweni kwezakhiwo kunye nezakhiwo zanamhlanje.
Ubume be-A.HPMC kunye nokusebenza:
1.Ulwakhiwo lwekhemikhali:
I-Hydroxypropylmethylcellulose inesakhiwo esiyinkimbinkimbi esine-hydrophilic kunye ne-hydrophobic parts. Amaqela e-hydroxypropyl kunye ne-methyl aqaliswe ngexesha lokudityaniswa anika iipropati ezithile ze-molecule.
2. Ukunyibilika kwamanzi:
I-HPMC i-soluble yamanzi, ivumela ukuba inyibilike emanzini abandayo ukwenza isisombululo esicacileyo kunye ne-viscous. Le propati ibaluleke kakhulu kwizicelo zodaka lomxube owomileyo njengoko iqinisekisa ukusasazwa okufanelekileyo kunye nokufana komxube wokugqibela.
3. I-Thermal Gelation:
I-HPMC ifumana inkqubo yokubuyisela i-thermogelling, oku kuthetha ukuba ingenza ijeli xa ishushu kwaye ibuyele kwisisombululo xa ipholile. Oku kuziphatha kunceda ukuphucula ukugcinwa kwamanzi kunye nokusebenza komxube wodaka.
4. Isakhono sokwenza ifilimu:
I-HPMC ineempawu zokwenza ifilimu kwaye yenza ifilimu ekhuselayo kumphezulu wamasuntswana odaka. Ifilimu iphakamisa ukunamathela, inciphisa uthuli, kwaye iphucula ukuqina okupheleleyo kodaka.
B. Indima ye-HPMC kudaka olomileyo oluxutyiweyo:
1. Ukugcinwa kwamanzi:
Omnye weyona misebenzi iphambili ye-HPMC kumxube owomileyo wodaka kukuphucula ukugcinwa kwamanzi. Ubume be-hydrophilic ye-molecule ye-HPMC ivumela ukuba ifunxe kwaye igcine ukufuma, ikhusela udaka ukuba lome ngaphambi kwexesha. Oku kubalulekile ekusebenzeni kwexesha elide kunye nokunyangwa okuchanekileyo kodaka.
2. Phucula ukusebenza:
Ukongeza i-HPMC kwimixube eyomileyo yodaka kuphucula ukusebenza kunye nokungaguquguquki. Inceda ukufezekisa ukufakwa okugudileyo kunye nokufakwa kodaka, okwenza kube lula ukuphatha kunye nokubeka.
3. Nciphisa ukudodobala:
I-HPMC inegalelo kuxhathiso lwe-sag yodaka, luyithintele ekuweni okanye ekujikeni kumphezulu othe nkqo. Oku kubaluleke ngakumbi xa usebenza kwiindawo eziphakamileyo okanye kwiindonga.
4. Nyusa ukuncamathela:
Ifilimu yokwenza ifilimu ye-HPMC inceda ukuphucula ukunamathela phakathi kodaka kunye ne-substrates eyahlukeneyo. Oku kubalulekile ekufezekiseni iibhondi ezinamandla nezihlala ixesha elide kwizicelo zokwakha.
5. Impembelelo ekumiseleni ixesha:
Ngelixa i-HPMC ayichaphazeli kakhulu ixesha lokuqala lokumisela lodaka, inokuchaphazela inkqubo yokuhanjiswa kwamanzi kunye negalelo ekuphuhliseni amandla exesha elide.
6. Ukuguquguquka kunye nokumelana nokuqhekeka:
Ifilimu eyenziwe yi-HPMC inika ukuguquguquka kodaka, okwenza kube nzima ukumelana nokuqhekeka. Oku kunenzuzo ngakumbi apho kunokwenzeka ukuba intshukumo yesakhiwo inokwenzeka.
7. Uzinzo phantsi kweemeko ezinzima:
I-HPMC ibonelela ngodaka oluxubeneyo olomileyo olunozinzo phantsi kweemeko ezahlukeneyo zokusingqongileyo, kubandakanywa ukuvezwa kweemeko zemozulu ezinzima. Iphucula ukuqina kunye nokusebenza kodaka.
C.Amanqaku eSicelo:
1. Umthamo:
Isixa esifanelekileyo se-HPMC sixhomekeke kwiimfuno ezithile zomxube wodaka, kuquka iipropati ezifunwayo kunye neemeko zesicelo. Ukuqwalaselwa ngononophelo kunye novavanyo kubalulekile ekumiseleni idosi efanelekileyo.
2. Ukuhambelana:
I-HPMC iyahambelana neentlobo ngeentlobo zezinye izongezo kunye nezithako ezidla ngokusetyenziswa kwimixube eyomileyo yodaka. Nangona kunjalo, uvavanyo lokuhambelana kufuneka lwenziwe ukuze kuqinisekiswe ukusebenza okufunekayo kwaye kuphephe nayiphi na intsebenziswano embi.
3. Imigangatho yomgangatho:
Umgangatho we-HPMC osetyenziswa kumdaka womxube owomileyo kufuneka uhambelane nemigangatho yoshishino kunye neenkcukacha. Ukuthotyelwa kwemigangatho yomgangatho kuqinisekisa ukusebenza kodaka olungaguqukiyo noluthembekileyo.
ukuququmbela:
IHydroxypropyl methylcellulose (HPMC) sisongezo esisebenza ngezinto ezininzi esidlala indima ebalulekileyo ekuphuculeni ukusebenza kodaka lomxube owomileyo. Indibaniselwano yayo eyodwa yeepropati, kubandakanywa ukugcinwa kwamanzi, ukuphuculwa kokusebenza kunye nokukwazi ukwenza ifilimu, kuyenza ibe yinxalenye ebalulekileyo yenkqubo yokwakha yanamhlanje. Njengoko izinto zokwakha ziqhubeka nokuguquka, ukusetyenziswa kwe-HPMC kwimixube eyomileyo yodaka kunokunceda ukuphuhlisa izinto ezihlala ixesha elide, eziguquguqukayo kunye nezizinzileyo.
Ixesha lokuposa: Dec-18-2023