Hydroxypropyl methylcelculose (hpmc)yindawo esetyenziswayo esetyenziswa yindalo yendalo kwaye isetyenziswa ngokubanzi kumalungiselelo amayeza, ukuqhubekeka nokwakha, ukwakhiwa, i-cosmetics kunye namanye amasimi. Iipropathi zayo zokwenyama, ngakumbi viscofity kunye nokudlulisela, yinempembelelo ebalulekileyo ekusebenzeni kwayo kwesicelo.
I-1. Ubunzima bemolekyuli
Ubunzima bemolekyuli yenye yezona zinto zibalulekileyo ezichaza ukusebenza kwe-HPMC. Njengobunzima be-molecular ye-kimbacell®hpmc bonyusa, i-molecular thein iba ixesha elide kwaye i-vickosity yesisombululo idla ngokunyuka. Kungenxa yokuba amakhonkco amade ama-molecular anemikhosi enamandla kakhulu kwisisombululo, okukhokelela kulwelo oluhlwempuzekileyo, olubonakala njengofaneko oluphezulu. Ngokwahlukileyo, izisombululo ze-HPMC ezinolwazi olusezantsi lweemolekyuli zinobuqhetseba obuqinileyo kunye ne-viscofity esezantsi.
Ubunzima bemolekyuli bunobudlelwane obuthile kunye nokuguqula. Ngokubanzi, izisombululo ze-HPMC ezinomonde omkhulu weemolekyuli zinokwenza izakhiwo ezikhulu zemolekyuli ngenxa yeemolekyuli zazo zemolekyuli, ezichaphazela ukwehla kokukhanya.
I-2. I-HydroxyPLLL kunye ne-methytrance degree
Isakhiwo sekhemikhali se-HPMC ibandakanya i-hydroxypropy kunye namaqela e-methyl, kunye nokungeniswa kwala maqela kuchaphazela kakhulu ukuluka, i-viscosity kunye nokudlulisela. Ngokubanzi, yandisa inqanaba le-hydroxyyprovyplopy inokuphucula ukubethwa kwe-HPMC, ngelixa inyusa umgangatho we-methysity inokunceda ukwandisa i-complofity kwaye ugcine uzinzo lwe-colloid.
Inqanaba le-methylid: Ukunyuka kwinqanaba le-methylid kuya kukhokelela ekunyukeni konxibelelwano phakathi kweemolekyuli ze-HPMC, ngaloo ndlela kunyusa ukubonakala kwesisombululo. Inqanaba eliphezulu kakhulu lezigidi lezigidi linokubangela ukumiswa kwesisombululo ukuba mkhulu kakhulu, kuchaphazela ukungafihlisi.
Inqanaba le-hydroxyypropypy: Ukungeniswa kwamaqela e-hydroxypropy yonyusa i-sholekyuli yeemolekyuli, kuphucula ukwahlula i-HPMC, kwaye kunceda ukwenziwa kwenkqubo yecophoid. Inqanaba eliphezulu kakhulu le-hydroxyy inokuthi inciphise ukucaca kwesisombululo, ngaloo ndlela ichaphazela ukuhambisa.
3. Iipropathi zeShorvent
Ukunyibilisela i-HPMC kunye nohlobo lwesisombululo kuchaphazeleka kakhulu ziipropathi zesinyibilikisi. Ngokubanzi, i-HPMC inokutshitshiswa kakuhle emanzini, kodwa ukulingana kwayo kuyachaphazeleka ngezinto ezinje ngeqondo lobushushu, ixabiso le-pH, kunye netyuwa yamanzi.
Iqondo lokushisa: Iqondo lobushushu elivunyiweyo lihlala linceda ukunyibilikisa i-HPMC kwaye kunciphisa i-viscosity yesisombululo. Nangona kunjalo, ukuba amaqondo obushushu aphezulu kakhulu, kunokubangela ukonakaliswa kwe-HPMC, echaphazela i-viscofity yalo kunye nokudlulisela.
Ixabiso le-pH: Ukuzalwa kunye nokubonisa i-HPMC kukwachaphazeleka yiPh. Ukuluka kunye nokucombulula isisombululo se-HPMC kungahluka kwiinqobo ezahlukeneyo ze-ET, ngakumbi phambi kokugxila okuphezulu kwe-acid okanye i-Alkali, apho ukunyibilika kwe-HPMC kunokwehla okanye ukwanda kakhulu.
Isimo esongelwe amandla: ukuba isixa esikhulu setyiwa yongezwa kwisisombululo, amandla e-Ionic yesisombululo esonyukayo, esinokuchaphazela ukusebenzisana phakathi kweemolekyuli ze-HPMC kwaye utshintsha i-viscofity.
I-4. I-HPMC ye-HPMC
Uxinzelelo lwe-HPMC inefuthe ngqo kuhlobo lwe-viscosity yesisombululo. Ngokubanzi, umzobo wesisombululo unyusa umgca ngokudibeneyo ngokunyuka kwe-HPMC. Nangona kunjalo, ngamacala aphezulu, isisombululo sinokufikelela kumda othile wokubonakala, apho ikhoyo yokuphucula ukugxininisa kwi-vickosity kuya kuba buthathaka.
Ukwanda koxinzelelo kunokuchaphazela ukucaca kwesisombululo se-HPMC. Izisombululo ezixineneyo zinokwenza amasuntswana amakhulu okanye amagqabantshintshi ngenxa yokunxibelelana okuqinileyo phakathi kweemolekyuli, okukhokelela ekukhuliseni okukhanyayo kunye nokusebenzisa ukuguqula.
I-5. Ixabiso le-Shear kunye nembali yeShear
I-viscofity kunye nokuhanjiswa kwe-kimbacell®HPMMCMM® ichaphazelekayo kwinqanaba le-Shear (okt, inqanaba lokuhamba) kunye nembali ye-Shear) kunye nembali ye-Shear) kunye nembali ye-Shear) kunye nembali ye-Shear) kunye nembali ye-Shear) kunye nembali ye-Shear. Ukuphakama kwenqanaba le-Shear, komelele ulwelo lwesicombululo kunye nokuhla kwe-viscofity. Ukucheba okwexesha elide kunokukhokelela ekuthandeni ubuyeko lweemolekyuli, oko ke kuchaphazela i-viscofity kunye nokudlulisela isisombululo.
Imbali ye-Shear ifuthe elikhulu ekuziphatheni kakuhle kwesisombululo se-HPMC. Ukuba isisombululo siphantsi kokucheba ixesha elide, ukusebenzisana phakathi kweemolekyuli ze-HPMC kunokutshatyalaliswa, kukhokelela ekunciphiseni kwesisombululo, kwaye kunokuchaphazela ukutshintsha.
I-6. Iisongezo zangaphandle
Kwisisombululo se-HPMC, esongeza iintlobo ezahlukeneyo zezongezo (njengamantshontsho, ukuzinza, iityuwa, njl.). Umzekelo, ezinye iziqwengana zinokusebenzisana nge-HPMC ukuba yenze isbussms, ngaloo ndlela kukhulisa ukubonakala kwesisombululo. Ukongeza, ukongezwa kwezithunzi ezithile zinokulungelelanisa ngakumbi ukulinganisa kunye nokubonisa i-HPMC ngokutshintsha amandla e-ionic yesisombululo.
Izitulo: Ezi zongezo zihlala zandisa i-viscosity yesisombululo se-HPMC, kodwa ukusetyenziswa kakhulu kunokubangela isisombululo sokuba nesisombululo se-viscofity egqithisileyo.
I-surfacapecapes: Ukongezwa kwe-surfacants kunokuphucula ukuzinza kwesisombululo se-HPMC, kodwa ngamanye amaxesha kunokutshintsha i-molekyuli yayo, kuba iimolekyuli ze-susflogement zinokusebenzisana neemolekyuli ze-HPMC kwaye zichaphazele ukusasazwa kokukhanya.
7. Iimeko zokugcina isisombululo
Iimeko zogcino lwe-kimbacell®hpmc zinefuthe elibalulekileyo kwi-viscofity yalo kunye nokuhambisa. Ukugcina ixesha elide kunokubangela utshintsho kuhlobo lwesisombululo se-HPMC, ngakumbi kwindawo eneqondo lobushushu elingazinzanga okanye ukukhanya okuqinileyo. Iqondo lobushushu eliphezulu okanye ukuvezwa kwexesha elide kuLwandle i-Ultraviolet kunokubangela ukonakaliswa kwe-HPMC, echaphazela i-viscosity yesisombululo kwaye kunokubangela utshintsho kwi-Delimittance.
I-viscofity kunye nokuguqulaI-HPMCzichatshazelwa zizinto ezininzi, ikakhulu zibandakanya ubunzima bemolekyuli, inqanaba le-hydroxypropy kunye ne-methyred, i-methyvest, iipropathi ze-SOLVE, i-Shear, iiMeko zeShear, kunye neemeko zokugcina isisombululo. Ngokuhlengahlengisa ngokubonakalayo ezi zinto, izisombululo ze-HPMC ezinepropathi ethile zinokwenziwa njengoko kufuneka zifezekise iimfuno zesicelo zamacandelo awo ahlukeneyo.
IXESHA LOKUQALA: NgoFebwe-24 ukuya ku-2425