IHydroxypropylmethylcellulose (HPMC) yenye yezona zinto zixhaphakileyo kumashishini axuba amayeza nokutya kunye nakwishishini lokwakha. Enye yeenzuzo eziphambili ze-HPMC kukukwazi ukugcina amanzi, okwenza kube kuhle kwiintlobo ezahlukeneyo zezicelo. Ukusebenza kokugcinwa kwamanzi kwe-HPMC kuchatshazelwa yimiba emininzi, kubandakanywa i-viscosity, umxholo, ubushushu be-ambient kunye nesakhiwo se-molecular.
i-viscosity
Enye yezinto eziphambili ezichaphazela ukugcinwa kwamanzi kwi-HPMC yi-viscosity yayo. I-Viscosity ibhekisela kubukhulu okanye ukuchasana nokuhamba kwezinto. Kwi-HPMC, iphezulu i-viscosity, iphezulu ukugcinwa kwamanzi.
I-viscosity ephezulu HPMC inobunzima obuphezulu bemolekyuli, okuthetha ukuba amatyathanga epolymer amade. Amatyathanga amade enza kube nzima ukuba iimolekyuli zamanzi zihambe kwizinto eziphathekayo. Oku kubangela ukugcinwa kwamanzi okuphezulu njengoko iimolekyuli zamanzi zivaleleke ngaphakathi kwe-polymer matrix, ephakamisa amandla onke e-matrix.
umxholo
Enye into echaphazela ukusebenza kokugcinwa kwamanzi kwe-HPMC ngumxholo. I-HPMC inamacandelo amabini aphambili anamanqanaba ahlukeneyo e-hydrophilicity, angala, i-methoxyl kunye ne-hydroxypropyl. Ukuphakama komxholo we-hydroxypropyl kwi-HPMC, ubukhulu bokugcina umthamo wamanzi.
Iqela le-hydroxypropyl kwi-HPMC inquma ukusebenza kwayo kokugcinwa kwamanzi. La maqela atsala kwaye agcine iimolekyuli zamanzi, ezibangela ukuba i-HPMC idumbe. Oku kudumba kunceda ukwenza umqobo ocotha ukukhutshwa kwamanzi kwi-HPMC. Amaqela e-Methoxy, ngakolunye uhlangothi, awekho njenge-hydrophilic njengamaqela e-hydroxypropyl kwaye ngoko awafaki negalelo elikhulu kumandla okugcina amanzi.
ubushushu obugciniwe
Ubushushu be-Ambient yenye into echaphazela ukugcinwa kwamanzi kwi-HPMC. Njengoko ubushushu bukhula, umthamo wokugcina amanzi we-HPMC uyancipha. Oku kwenzeka ngenxa yokuba kumaqondo obushushu aphezulu, imixokelelwane ye-polymer ye-HPMC inamandla amaninzi e-kinetic, kwaye ihamba ngokukhawuleza. Ngenxa yoko, iimolekyuli zamanzi zikhululwa ngokukhawuleza kwi-matrix ye-polymer. Kwakhona, kumaqondo obushushu asezantsi, iimolekyuli zamanzi ziqiniswe ngakumbi kwi-matrix ye-HPMC, okukhokelela ekugcinweni okuphezulu kwamanzi.
Ngoko ke, kubalulekile ukulawula ubushushu be-ambient ngexesha lenkqubo yokuvelisa ukuqinisekisa ukusebenza okufanayo kunye nokuthembekileyo kokugcinwa kwamanzi.
Ulwakhiwo lweemolekyuli
Amandla okugcina amanzi e-HPMC nawo achatshazelwa sisakhiwo sayo semolekyuli. Ubume bemolekyuli ye-HPMC imiselwe yinqanaba lokuthatha indawo (DS) kunye nokusabalalisa ubunzima bemolekyuli.
Iqondo lokutshintsha libhekiselele kwinqanaba apho amaqela e-hydroxyl e-cellulose athatyathwa ngamaqela e-hydroxypropyl. I-HPMC eneqondo eliphezulu lokutshintshwa inomthamo ophezulu wokugcina amanzi. Ngokwahlukileyo, i-HPMC eneqondo elisezantsi lokutshintsha inomthamo ophantsi wogcino lwamanzi.
Ukuhanjiswa kobunzima bemolekyuli ye-HPMC ikwachaphazela amandla okugcina amanzi. Ukuphakama kobunzima bemolekyuli, kokukhona uphezulu umthamo wokugcina amanzi, njengoko iimolekyuli ezinkulu zenza ulwakhiwo lwematrix oluqina olubamba iimolekyuli zamanzi ngokuthe nkqi.
ukuququmbela
I-HPMC sisixhobo esiluncedo kakhulu ngenxa yezinto ezigqwesileyo zokugcina amanzi. Umthamo wokugcina amanzi we-HPMC uhambelana ngokuthe ngqo kwi-viscosity yayo, umxholo, ubushushu be-ambient kunye nesakhiwo se-molecular. Ngoko ke, ukukhetha i-HPMC efanelekileyo kwisicelo esithile kufuna ukuqwalaselwa ngononophelo kwezi zinto. Lilonke, i-HPMC inempembelelo entle kumgangatho kunye nokusebenza kakuhle kweemveliso ezahlukeneyo kumashishini amaninzi, kubandakanya amayeza, ukutya kunye nokwakha.
Ixesha lokuposa: Aug-30-2023