IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa kakhulu kumalungiselelo amayeza, ikakhulu esetyenziselwa ukwandisa ixesha lokukhululwa kwamachiza. I-HPMC yi-semi-synthetic cellulose derivative kunye ne-solubility yamanzi kunye neempawu zokwenza ifilimu. Ngokulungelelanisa ubunzima be-molecular, i-concentration, viscosity kunye nezinye iipropathi ze-HPMC, izinga lokukhululwa kwamachiza linokulawulwa ngokufanelekileyo, ngaloo ndlela lifezekisa ukukhutshwa kwexesha elide kunye nokugcinwa kweziyobisi.
1. Ubume kunye nendlela yokukhutshwa kweziyobisi ye-HPMC
I-HPMC yenziwa yi-hydroxypropyl kunye ne-methoxy substitution yesakhiwo seselulosi, kunye nesakhiwo sayo sekhemikhali inika ukudumba okulungileyo kunye neempawu zefilimu. Xa udibana namanzi, i-HPMC ifunxa ngokukhawuleza amanzi kwaye idumbe ukwenza umaleko wejeli. Ukwenziwa kolu maleko lwejeli yenye yeendlela eziphambili zokulawula ukukhutshwa kweziyobisi. Ubukho bomaleko wejeli kuthintela ukungena okuthe kratya kwamanzi kwi-matrix yechiza, kwaye ukusasazwa kwechiza kuthintelwa ngumaleko wejeli, ngaloo ndlela kulibazisa ukukhutshwa kweyeza.
2. Indima ye-HPMC kumalungiselelo okukhululwa okuzinzileyo
Kumalungiselelo okukhutshwa okuzinzileyo, i-HPMC idla ngokusetyenziswa njenge-matrix elawulwayo yokukhutshwa. Iyeza lichithwa-chithwa okanye linyibilikisiwe kwi-matrix ye-HPMC, kwaye xa idibene ne-gastrointestinal fluid, i-HPMC iyadumba kwaye yenze umaleko wejeli. Njengoko ixesha lihamba, i-gel layer ikhula ngokuthe ngcembe, yenze umqobo womzimba. Ichiza kufuneka likhutshelwe kumbindi wangaphandle ngokusasazwa okanye ukukhukuliseka kwe-matrix. Indlela yokusebenza kwayo ikakhulu ibandakanya le miba mibini ilandelayo:
Indlela yokudumba: Emva kokuba i-HPMC idibana namanzi, umaleko womphezulu ufunxa amanzi kwaye udumbe ukwenza umaleko wejeli ye-viscoelastic. Njengoko ixesha lihamba, i-gel layer ikhula ngokuthe ngcembe ngaphakathi, i-external layer ihluma kwaye ihlambuluke, kwaye i-inner layer iqhubeka isenza i-gel entsha. Le nkqubo yokudumba okuqhubekayo kunye nejeli ilawula izinga lokukhululwa kweyeza.
Indlela yokusasaza: Ukusasazwa kwamachiza ngoluhlu lwejeli yenye indlela ebalulekileyo yokulawula izinga lokukhululwa. Umaleko wejeli we-HPMC usebenza njengomqobo wokusasaza, kwaye ichiza kufuneka lidlule kulo maleko ukufikelela kwi-in vitro medium. Ubunzima be-molecular, i-viscosity kunye nokugxilwa kwe-HPMC ekulungiseleleni kuya kuchaphazela iipropati ze-gel layer, ngaloo ndlela ilawula izinga lokusasazwa kweyeza.
3. Izinto ezichaphazela i-HPMC
Kukho izinto ezininzi ezichaphazela ukukhutshwa okulawulwayo kokusebenza kwe-HPMC, kubandakanywa ubunzima bemolekyuli, i-viscosity, i-dosage ye-HPMC, i-physical and chemical properties of the drug, kunye nendalo yangaphandle (efana ne-pH kunye namandla e-ionic).
Ubunzima bemolekyuli kunye ne-viscosity ye-HPMC: Ubukhulu be-molecular weight ye-HPMC, iphezulu i-viscosity ye-gel layer kunye nesantya sokukhululwa kwechiza. I-HPMC ene-viscosity ephezulu inokwenza umaleko wejeli oqina ngakumbi, ithintele izinga lokusasazwa kwechiza, ngaloo ndlela isolula ixesha lokukhutshwa kwechiza. Ngoko ke, ekuqulunqweni kwamalungiselelo okukhululwa okuqhubekayo, i-HPMC enezisindo ezahlukeneyo ze-molecular kunye ne-viscosities zihlala zikhethwa ngokweemfuno zokufezekisa umphumo olindelekileyo wokukhululwa.
Ugxininiso lwe-HPMC: Uxinzelelo lwe-HPMC lukwayinto ebalulekileyo ekulawuleni izinga lokukhutshwa kwechiza. Ukuphakama koxinzelelo lwe-HPMC, kokukhona umaleko wejeli ujiyile, kokukhona uxhathiso lokusasazwa kwechiza lisebenzisa umaleko wejeli, kwaye kokukhona licotha izinga lokukhululwa. Ngokulungelelanisa idosi ye-HPMC, ixesha lokukhululwa kwechiza linokulawulwa ngokuguquguqukayo.
Iimpawu zePhysicochemical yamachiza: Ukunyibilika kwamanzi, ubunzima bemolekyuli, ukunyibilika, njl.njl. ichiza kuya kuchaphazela ukukhululwa kwalo kwimatrix ye-HPMC. Amachiza ane-solubility efanelekileyo yamanzi, iyeza linokunyibilika emanzini ngokukhawuleza kwaye lisasazeke kwi-gel layer, ngoko ke izinga lokukhululwa likhawuleza. Kwiziyobisi ezinobunzima bokunyibilika kwamanzi, ukunyibilika kuphantsi, iyeza lisasazeka kancinci kumaleko wejeli, kwaye ixesha lokukhululwa lide.
Impembelelo yendawo yangaphandle: Iipropathi zejeli ze-HPMC zinokwahluka kwiindawo ezinexabiso elahlukileyo le-pH kunye namandla e-ionic. I-HPMC inokubonisa iindlela ezahlukeneyo zokuziphatha zokudumba kwiindawo ezineasidi, ngaloo ndlela ichaphazela izinga lokukhutshwa kwamachiza. Ngenxa yotshintsho olukhulu lwe-pH kwindlela yesisu somntu, ukuziphatha kwe-matrix ye-HPMC yamalungiselelo okukhululwa okuqhubekayo phantsi kweemeko ezahlukeneyo ze-pH kufuna ingqalelo ekhethekileyo ukuqinisekisa ukuba ichiza linokukhutshwa ngokuzinzileyo nangokuqhubekayo.
4. Ukusetyenziswa kwe-HPMC kwiindidi ezahlukeneyo zamalungiselelo okukhutshwa okulawulwayo
I-HPMC isetyenziswa ngokubanzi kumalungiselelo okukhutshwa okuzinzileyo eefomu ezahlukeneyo zedosi ezifana neepilisi, iipilisi, neegranules. Kwiipilisi, i-HPMC njengesixhobo se-matrix sinokwenza umxube ofanayo we-chiza-polymer kwaye ngokuthe ngcembe ikhulule iyeza kwi-gastrointestinal tract. Kwii-capsules, i-HPMC iphinda isetyenziswe njenge-membrane yokukhululwa elawulwayo ukuze igqume amasuntswana eziyobisi, kwaye ixesha lokukhululwa kweyeza lilawulwa ngokuhlengahlengisa ubukhulu kunye ne-viscosity ye-coating layer.
Ukusetyenziswa kwiipilisi: Iipilisi zezona ziqhelekileyo zedosi yomlomo, kwaye i-HPMC isoloko isetyenziselwa ukufezekisa umphumo wokukhululwa kwamachiza. I-HPMC inokuxutywa namachiza kwaye icinezelwe ukwenza inkqubo ye-matrix esasazwe ngokufanayo. Xa ithebhulethi ingena kumzila wesisu, umphezulu we-HPMC udumba ngokukhawuleza kwaye wenze ijeli, ethoba isantya sokuchithwa kwechiza. Ngexesha elifanayo, njengoko i-gel layer iqhubeka ikhula, ukukhululwa kweyeza langaphakathi kulawulwa ngokuthe ngcembe.
Ukusetyenziswa kwii-capsules:
Kumalungiselelo e-capsule, i-HPMC idla ngokusetyenziswa njenge-membrane yokukhululwa elawulwayo. Ngokulungelelanisa umxholo we-HPMC kwi-capsule kunye nobukhulu befilimu yokugubungela, izinga lokukhululwa kweyeza linokulawulwa. Ukongeza, i-HPMC ine-solubility efanelekileyo kunye ne-biocompatibility emanzini, ngoko inethuba elibanzi lesicelo kwiinkqubo zokukhululwa ezilawulwa yi-capsule.
5. Iindlela zophuhliso lwexesha elizayo
Ngokuqhubela phambili kweteknoloji yonyango, ukusetyenziswa kwe-HPMC akukhawulelwanga kuphela kumalungiselelo okukhutshwa okuzinzileyo, kodwa kunokudibaniswa nezinye iinkqubo ezintsha zokuhanjiswa kweziyobisi, ezifana ne-microspheres, nanoparticles, njl., ukufezekisa ukukhutshwa kweziyobisi ezilawulwa ngokuthe ngqo. Ukongeza, ngokuguqula ngakumbi ubume be-HPMC, njengokudibanisa nezinye iipholima, ukuguqulwa kweekhemikhali, njl., ukusebenza kwayo kumalungiselelo okukhutshwa okulawulwayo kunokwandiswa ngakumbi.
I-HPMC inokwandisa ngokufanelekileyo ixesha lokukhululwa kwamachiza ngendlela yayo yokudumba ukwenza umaleko wejeli. Izinto ezinjengobunzima bemolekyuli, i-viscosity, i-concentration ye-HPMC kunye neempawu ze-physicochemical zechiza ziya kuchaphazela umphumo walo wokukhululwa olawulwayo. Kwizicelo ezisebenzayo, ngokuyila ngokwengqiqo iimeko zokusetyenziswa kwe-HPMC, ukukhululwa okuqhubekayo kweentlobo ezahlukeneyo zamachiza kunokufezekiswa ukuhlangabezana neemfuno zeklinikhi. Kwixesha elizayo, i-HPMC inamathuba okusebenza okubanzi kummandla wokukhutshwa kwechiza okuzinzileyo, kwaye inokudityaniswa nobuchwepheshe obutsha ukukhuthaza ngakumbi uphuhliso lweenkqubo zokuhanjiswa kwechiza.
Ixesha lokuposa: Sep-19-2024