Indlela yeMveliso yesigaba soLiquid yokuVelisa iHydroxypropyl Methyl Cellulose (HPMC)

IHydroxypropyl methyl cellulose (HPMC) yi-ether eselulosi esetyenziswa kakhulu kwimizi-mveliso eyahlukeneyo kunye nezicelo zamayeza ngenxa yeempawu zayo ezibalaseleyo zomzimba kunye neekhemikhali. I-HPMC idla ngokuveliswa ngeendlela ezahlukeneyo, kuquka indlela yokuvelisa ulwelo.

Indlela yokuvelisa i-liquid-phase yinkqubo yokusabela kweekhemikhali ebandakanya ukuphendulwa kwe-methyl cellulose (MC) kunye nepropylene oxide (PO) kunye nepropylene glycol (PG) phantsi kweemeko ezithile. Inkqubo ibandakanya la manyathelo alandelayo:

1. Ukulungiswa kweMethyl Cellulose (MC)

I-MC ifunyanwa ngokunyanga i-cellulose nge-alkali kwaye emva koko i-methylating nge-methyl chloride. Iqondo lokuthatha indawo (DS) ye-MC imisela iipropati zayo kwaye inokulawulwa ngokuguquguquka kweemeko zokusabela.

2. Ukulungiswa kwePropylene oxide (PO)

I-PO ilungiselelwe yi-oxidation yepropylene isebenzisa umoya okanye i-oksijini phambi kwe-catalyst. Ukusabela kuqhutyelwa kumaqondo aphezulu kunye noxinzelelo lokuqinisekisa isivuno esiphezulu se-PO.

3. Ukusabela kwe-MC kunye ne-PO

Ukusabela kwe-MC kunye ne-PO kuqhutyelwa phambi kwe-catalyst kunye ne-solvent efana ne-toluene okanye i-dichloromethane. I-reaction yi-exothermic kwaye ivelisa ubushushu, ekufuneka ilawulwe ukunqanda ukusabela kokubaleka.

4. Ukulungiswa kwePropylene Glycol (PG)

I-PG ilungiswe yi-hydrolysis ye-propylene oxide usebenzisa amanzi okanye i-asidi efanelekileyo okanye isiseko se-catalyst. Ukusabela kuqhutywa phantsi kweemeko ezithambileyo ukufumana isivuno esikhulu sePG.

5. Ukusabela kwe-MC-PO nge-PG

Imveliso ye-MC-PO iye yaphendulwa nge-PG phambi kwe-catalyst kunye ne-solvent efana ne-ethanol okanye i-methanol. I-reaction kwakhona i-exothermic kwaye ivelisa ubushushu, ekufuneka ilawulwe ukunqanda ukusabela kokubaleka.

6. Ukuhlamba kunye nokomisa

Emva kokusabela, imveliso ihlanjwe ngamanzi kwaye yomiswe ukufumana i-HPMC. Imveliso idla ngokuhlanjululwa kusetyenziswa uchungechunge lokuhluza kunye namanyathelo e-centrifugation ukususa nakuphi na ukungcola.

Indlela yemveliso yesigaba solwelo ineengenelo ezininzi kunezinye iindlela, kubandakanywa isivuno esikhulu, ixabiso eliphantsi, kunye nokulula kokulinganisa. Ukusabela kunokwenziwa kwinqanawa enye, ukunciphisa imfuno yezixhobo ezinzima kunye neenkqubo.

Nangona kunjalo, indlela yokuveliswa kwesigaba solwelo nayo inezithintelo ezithile. Impendulo inokuvelisa ubushushu, ekufuneka ilawulwe ngononophelo ukuphepha imiba yokhuseleko. Ukusetyenziswa kwezinyibilikisi nako kunokubeka imingcipheko yokusingqongileyo kunye nempilo, kwaye inkqubo yokucoca inokuthabatha ixesha kunye neendleko.

Ukuqukumbela, indlela yokuveliswa kwesigaba solwelo yindlela esetyenziswa ngokubanzi yokuvelisa i-HPMC. Indlela ibandakanya ukusabela kwe-MC kunye ne-PO kunye ne-PG phantsi kweemeko ezithile, kulandelwa ukuhlanjululwa kunye nokomisa. Ngelixa le ndlela inezithintelo ezithile, iingenelo zayo zenza ukuba ibe lukhetho oludumileyo kwizicelo zamashishini kunye nezamayeza.