Umahluko phakathi kwe-hypromellose ekhawulezileyo kunye ne-hot soluble hypromellose

Okwangoku, i-hydroxypropyl methylcellulose kwimarike yasekhaya yohlulwe kakhulu ibe luhlobo lokunyibilika okushushu (ekwabizwa ngokuba luhlobo lokunyibilika kancinci) kunye nohlobo lokunyibilika kwangoko, kunye nohlobo lokunyibilika okushushu lolona luqhelekileyo nolona hlobo lusetyenziswayo lweselulosi.

I-Hot-melt (slow-melt) i-hydroxypropyl methylcellulose I-HPMC ayizange iphathwe nge-glyoxal. Ukuba inani le-glyoxal likhulu, ukusabalalisa kuya kukhawuleza, kodwa i-viscosity iya kwanda ngokukhawuleza, kwaye ukuba isixa sincinci, okuchaseneyo kuya kuba yinyani. IHydroxypropyl methylcellulose HPMC iya kudityaniswa xa idibana namanzi abandayo (kodwa le meko iya kunyibilika kancinci, kodwa ithatha ixesha elide.), Kodwa iya kusasazeka ngokukhawuleza emanzini kumanzi ashushu de Inyamalale ngokupheleleyo emanzini, kwaye i-viscosity yayo iyanda. ngokucothayo xa ubushushu behla ngokuthe ngcembe de ibe lulwelo lwe-viscous ebonakalayo. I-clumping phenomenon yayo ifana nokuchithwa kwe-high-viscosity sodium carboxymethyl cellulose. Xa i-cellulose powder ngaphandle kwamanzi iyancibilika, iba yi-viscous, ize ifake i-cellulose ngaphakathi engazange ichukumise amanzi, kodwa Le meko iya kutshabalalisa ngokukhawuleza, kodwa kuya kuthatha ixesha elide.

Udidi olukhawulezileyo lwe-hydroxypropyl methylcellulose HPMC lunyangwa umphezulu ngeglyoxal. Isasazeka ngokukhawuleza emanzini abandayo, kodwa ayinyibiliki ngokwenene. Kuthatha ixesha lokuba i-viscosity yayo iphakame, kuba isasazeka emanzini kuphela kwisigaba sokuqala, esingabalulekanga ngokwenene. Ngokuchithwa ngasentla, i-viscosity ifikelela kwixabiso eliphezulu malunga nemizuzu engamashumi amane. Xa i-viscosity iphakama, isisombululo samanzi siyacaca kwaye sibonakale, okuyiyona nto i-dissolution. I-Instant-type hydroxypropyl methylcellulose HPMC isetyenziswe kwishishini elithile kwaye ayiyi kuxutywa nomgubo owomileyo, okanye xa ifuna ukuchithwa kwaye amanzi ashushu ayinakusetyenziswa ngenxa yeemeko zezixhobo kunye nezinye izizathu, i-hypromellose esekelwe kwisisombululo esisekelwe kwi-cellulose. kwingxaki enzima ngolo hlobo.