Indlela yeMveliso yokuntywiliselwa kweAlkaline yeHydroxypropyl Methyl Cellulose (HPMC)

Indlela yokuvelisa i-alkaline yokuntywiliselwa yindlela eqhelekileyo yokuvelisa i-hydroxypropyl methyl cellulose (HPMC). Le ndlela ibandakanya ukuphendula kwe-cellulose kunye ne-sodium hydroxide (NaOH) kwaye emva koko ngepropylene oxide (PO) kunye ne-methyl chloride (MC) phantsi kweemeko ezithile.

Indlela yokuntywiliselwa kwealkaline inenzuzo yokuvelisa i-HPMC enenqanaba eliphezulu lokuthatha indawo (DS), emisela iimpawu zayo ezifana nokunyibilika, i-viscosity, kunye ne-gelation. Indlela ibandakanya la manyathelo alandelayo:

1. Ukulungiswa kweCellulose

I-cellulose ifumaneka kwimithombo yendalo efana nomthi, umqhaphu, okanye ezinye izinto zezityalo. I-cellulose ihlanjululwa kuqala kwaye iphathwe nge-NaOH ukwenza i-sodium cellulose, ephakathi kwe-reactive intermediate kwimveliso ye-HPMC.

2. Ukusabela kweSodium Cellulose kunye nePropylene Oxide (PO)

I-cellulose ye-sodium emva koko isabela nge-PO phambi kwe-catalyst efana ne-tetramethylammonium hydroxide (TMAH) okanye i-sodium hydroxide (NaOH) kumaqondo aphezulu kunye noxinzelelo. Ukusabela kubangela ukubunjwa kwe-hydroxypropyl cellulose (HPC).

3. Ukusabela kwe-HPC kunye neMethyl Chloride (MC)

I-HPC emva koko isabela nge-MC phambi kwe-catalyst efana ne-sodium hydroxide (NaOH) okanye i-hydrochloric acid (HCl). Ukusabela kukhokelela ekwakhiweni kwe-hydroxypropyl methyl cellulose (HPMC).

4. Ukuhlamba kunye nokomisa

Emva kokusabela, imveliso ihlanjwe ngamanzi kwaye yomiswe ukufumana i-HPMC. Imveliso idla ngokuhlanjululwa kusetyenziswa uchungechunge lokuhluza kunye namanyathelo e-centrifugation ukususa nakuphi na ukungcola.

Indlela yokuntywiliselwa kwealkaline ineengenelo ezininzi kunezinye iindlela, kubandakanya iDS ephezulu kunye nobunyulu, ixabiso eliphantsi, kunye nokulula ngokulula. Indlela ingasetyenziswa ukuvelisa HPMC kunye iipropati ezahlukeneyo ngokutshintsha iimeko reaction ezifana lobushushu, uxinzelelo, kunye noxinaniso.

Nangona kunjalo, le ndlela inezinye iingxaki. Ukusetyenziswa kwe-NaOH kunye ne-MC kunokubangela ukhuseleko kunye nemingcipheko yokusingqongileyo, kwaye inkqubo yokuvelisa inokudla ixesha kwaye idinga ubuninzi bamandla.

Ukuqukumbela, indlela yokuvelisa i-alkaline yindlela esetyenziswa ngokubanzi yokuvelisa i-HPMC. Indlela ibandakanya ukusabela kwe-cellulose kunye ne-NaOH, PO, kunye ne-MC phantsi kweemeko ezithile, ilandelwa ukuhlanjululwa kunye nokomisa. Ngelixa le ndlela inezithintelo ezithile, iingenelo zayo zenza ukuba ibe lukhetho oludumileyo kwizicelo zamashishini kunye nezamayeza.