Uvavanyo lwe-hydration paysistics ye-HydroxyPOpyl Methylcelcelcelse HPMC

Hydroxypropyl methylcelculose (hpmc)Ngaba i-polymer ye-solmmer esetyenziselwa amanzi asetyenziswa ngokubanzi kwizinto zokwakha, amayeza, ukutya kunye namashishini ekhemikhali. I-HPMC inesithukuthezi esihle, ukugcinwa kwamanzi, ukwenza ifilimu kunye neempawu ezibonisa iipropathi, kwaye kubaluleke kakhulu kwizixhobo ezisekwe kwizamente ezisekwe kunye neGypsim. Inkqubo yokupheliswa kwe-kimbacell®hpmc emanzini ichatshazelwa zizinto ezininzi, phakathi kwendawo yokugcwala yinto ephambili, ethatha umsebenzi wokwakha, obeka umgangatho wokugqibela wodaka, i-ifaket kunye nezinye iimveliso. Ke ngoko, ukufundisisa iimpawu zokulibaziseka kwe-HPMC kubaluleke kakhulu ekuqinisekiseni ifomu yezinto ezibonakalayo.

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Ukuchithwa kwe-HPMC emanzini kubandakanya amanqanaba amane: Ukumanziswa komgangatho, ukusasazeka kwexabiso, ukudumba kunye nokuchithwa. Xa amasuntswana aqhelekileyo e-HPMC aqhakamshelana ngqo namanzi, umaleko womphezulu uya kukhawulezisa amanzi ukuba enze i-gel manzi, ethintela ukugqabhuka kwamasuntswana angaphakathi, ngaloo ndlela ebonisa umdlalo wokulibaziseka. Ukwenzela ukuphucula ukusebenza kokwakha, ezinye iimveliso ze-HPMC ziphathwa ngokukodwa, njengokuthengiswa komphezulu okanye ukuphathwa gadalala, ukuqhubela phambili ixesha elivulekileyo kunye nokusebenza ngexesha lokwakha.

Izinto eziphambili ezichaphazela ukulibaziseka kwe-hyddication kubandakanya:

Ubungakanani bentsumpa

Unyango lomphezulu: Ezinye ii-HPMCs zinxibelelene okanye zidityaniswe nge-hydrophobil, ezinokulibazisa ngokungxama.

Iqondo lokushisa lesisombululo: Iqondo lokushisa elikhuselweyo linokukhawulezisa ukutshitshiswa kwe-HPMC, kodwa inokuchaphazela iimpawu zokulibaziseka kwe-hydration ngaphakathi kuluhlu oluthile.

Inkqubo yeSolvent: Ixabiso le-elektroly, ixabiso le-pH kunye nezinye izongezelelo zinokuchaphazela inqanaba lokuchitha kunye nexesha lokulibaziseka kwe-hpmc.

I-2. Uyilo lovavanyo kunye neendlela

2.1 Izinto zovavanyo

Iisampulu ze-HPMC (ii-viscofis ezahlukeneyo, iintlobo ezahlukeneyo zonyango)

Mamanzi amisiwe

Isixhobo esikhuthazayo

I-vismermeter (efana nokundwendwela)

I-Laser ye-Irver

2.2 Amanyathelo oluvavanyo

Ukuzimisela kwexesha lokulibaziseka kwe-hydration

Ngaphantsi kobushushu obuqhubekayo (25 ℃), isixa esithile se-kimbacell®hpmc sitshiswe amanzi ngaphandle kokuvuselela amasuntswana amdaka, kwaye ixesha elifunekayo lokuthathwa kwamanzi aqingqiweyo.

I-Viscosity itshintsha inyathelo

I-Viscofity yeSisombululo yalinganiswa yonke imizuzu emi-5 isebenzisa i-visment yokujikeleza ukurekhoda ukutyeshelwa kancinci kwamasuntswana e-HPMC.

Uvavanyo lwe-solbing

Isampulu yenziwa ngamanqaku ahlukeneyo, kwaye amasuntswana anqongopheleyo ahlukaniswe yi-membrane ye-filter ukumisela imeko ye-solity malunga nexesha.

Uhlalutyo lobungakanani

I-Laser ye-Laser ye-Istal isetyenziselwe ukulinganisa utshintsho kulwabiwo mali lwe-suricle ukusasazwa kwamasuntswana e-HPMC ngexesha lenkqubo yokulibazisa.

3. Iziphumo zovavanyo kunye nohlalutyo

Iziphumo zovavanyo zibonisa ukuba i-HPMC inamabanga ahlukeneyo e-Viscosity kunye neendlela zonyango eziphezulu zineempawu ezahlukeneyo ze-hydication. I-HPMC ngaphandle konyango olungaphezulu

Iziphumo zoVavanyo kwi-hydration lokulibaziseka

Amasuntswana asezantsi e-HPMC anemigangatho emifutshane yokulibaziseka ngenxa yobunzima beemolekyuli zabo; I-HPMMC ephezulu ye-HPMC inexesha elide lokulibaziseka kwe-hydical ixesha elifanelekileyo kwimozulu ye-molecular yayo.

Iziphumo zonyango lomphezulu kwi-hydration lokulibaziseka

I-HPMCsussussungus eziphathwe nge-hydrophobic ihlelo lokuthintela i-Hotenation yamanzi, kwaye ixesha lokulibaziseka kwe-hyddical lingandiswa ukuya kwimizuzu eli-10 ukuya kwengama-30.

Iziphumo zokuhanjiswa kwesahlulo

Amasuntswana amahle anexesha elifutshane lokulibaziseka, ngelixa amasuntswana amakhulu anengxaki yokulibaziseka okubalulekileyo ngenxa yempembelelo ye-gel gel.

Ukhetho lwengqondo lweI-HPMCUnokwenza isicelo sayo ekwakhiweni nasekuphuculeni amanye amashishini, ukuphucula ukusebenza kokuqala kunye nokuzinza kwempahla. Olu phononongo lunokubonelela ngesiseko sesayensi kulungelelwaniso lwe-HPMC kunye noPhuculo lweMveliso kunye nolungelelwaniso