Ukumiselwa okulula koMgangatho weHydroxypropyl MethylCellulose

IHydroxypropyl Methylcellulose (HPMC) yipolymer esetyenziswa ngokuqhelekileyo kwishishini loxubo-mayeza njenge-excipient okanye njenge-agent yokugquma iipilisi kunye nee-capsules. Umgangatho we-HPMC unokumiselwa ngeeparamitha ezahlukeneyo, ezifana ne-viscosity, umxholo wokufuma, ukusabalalisa ubungakanani bamasuntswana, kunye nokucoceka.

Enye indlela elula yokumisela umgangatho we-HPMC kukulinganisa i-viscosity yayo. I-Viscosity ngumlinganiselo wokumelana nolwelo ukuhamba, kwaye inxulumene ngokuthe ngqo kubunzima bemolekyuli ye-HPMC. Ubunzima bemolekyuli obuphezulu HPMC iya kuba viscosity ephezulu kuneezantsi ubunzima bemolekyuli HPMC. Ke ngoko, okukhona i-viscosity ephezulu ye-HPMC, iphezulu umgangatho wayo.

Enye iparameter ebalulekileyo ekufuneka iqwalaselwe sisiqulatho sokufuma se-HPMC. Ukufuma okugqithisileyo kunokukhokelela ekuthotyweni kwe-HPMC, okunokunciphisa ukusebenza kwayo. Uluhlu olwamkelekileyo lokunyakama kwe-HPMC luyehluka ngokuxhomekeke kusetyenziso olucetywayo, kodwa ngokwesiqhelo kufuneka lube ngaphantsi kwe-7%.

Ukuhanjiswa kobungakanani besuntswana le-HPMC kwakhona yinto ebalulekileyo ekumiseleni umgangatho wayo. I-HPMC kunye nokusabalalisa ubungakanani be-particle emxinwa iyakhethwa kuba ivumela imveliso ehambelanayo kunye neyunifomu. Ukuhanjiswa kobungakanani bamasuntswana kunokumiselwa kusetyenziswa iindlela ezahlukeneyo ezifana ne-laser diffraction okanye i-microscope.

Okokugqibela, ukucoceka kwe-HPMC kufuneka kwakhona kuhlolwe. Ukucoceka kwe-HPMC kunokumiselwa ngokuhlalutya ukwakheka kweekhemikhali kusetyenziswa ubuchule obufana ne-high-performance liquid chromatography (HPLC) okanye iFourier-transform infrared spectroscopy (FTIR). Ukungcola kwi-HPMC kunokuchaphazela ukhuseleko kunye nokusebenza kwayo.

Ukuqukumbela, umgangatho we-HPMC unokumiselwa ngokulinganisa i-viscosity yayo, umxholo wokufuma, ukusabalalisa ubungakanani bamasuntswana, kunye nobunyulu. Ezi parameters zinokuvavanywa ngokulula kusetyenziswa iindlela ezahlukeneyo zobugcisa, kwaye i-HPMC ekumgangatho ophezulu kufuneka ibe ne-viscosity ephezulu, umxholo wokufuma ophantsi, ukusabalalisa ubungakanani bamasuntswana, kunye nokucoceka okuphezulu.