Iingxaki ekuSetyenzisweni kweHydroxypropyl methylcellulose

IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa ngokubanzi kumashishini ahlukeneyo, kubandakanywa amayeza, ukutya, kunye namashishini okuthambisa, ngenxa yeempawu zayo ezizodwa, ezifana ne-solubility ephezulu, ukuzinza kwe-thermal, kunye nokukwazi ukwenza ifilimu. Nangona kunjalo, kukho iingxaki ezininzi ezinxulumene nokusetyenziswa kwe-HPMC, ezinokuchaphazela ukusebenza kwayo kunye nokusebenza kwayo. Kweli nqaku, siza kuxubusha ezinye zeengxaki eziqhelekileyo ekusetyenzisweni kwe-HPMC kunye nezisombululo zabo ezinokwenzeka.

1. I-viscosity engahambelaniyo

Enye yeengxaki eziqhelekileyo kwisicelo se-HPMC yi-viscosity engahambelani yesisombululo. I-HPMC ifumaneka kumabakala ahlukeneyo, kwaye i-viscosity yebakala ngalinye inokwahluka ngokuxhomekeke kwizinto ezifana neqondo lokutshintshela, ubunzima bemolekyuli, kunye nobungakanani besuntswana. Ngenxa yoko, kunokuba ngumngeni ukufezekisa i-viscosity ehambelanayo yesisombululo se-HPMC.

Isisombululo: Ukoyisa le ngxaki, kubalulekile ukusebenzisa i-HPMC yebakala elihambelanayo kunye nomgangatho. Abavelisi kufuneka banikezele ngolwazi olucacileyo malunga neempawu zeemveliso zabo ze-HPMC, ezifana noluhlu lwe-viscosity, ukusabalalisa ubungakanani be-particle size, kunye ne-degree of substitution, ukunceda abasebenzisi ukuba bakhethe ibakala elifanelekileyo kwisicelo sabo esithile. Ukongezelela, kucetyiswa ukusebenzisa i-viscometer ukulinganisa i-viscosity yesisombululo se-HPMC ngexesha lenkqubo yokulungiselela ukuqinisekisa ukuhambelana.

2. Ukunyibilika kakubi

Enye ingxaki enxulumene ne-HPMC kukunyibilika kakubi. I-HPMC yipolymer enyibilikayo emanzini, kodwa ukunyibilika kwayo kunokuchatshazelwa yimiba efana ne-pH, ubushushu, kunye nobukho bezinye izongezo.

Isisombululo: Ukuphucula ukunyibilika kwe-HPMC, kuyacetyiswa ukuba usebenzise umgangatho ophezulu wemveliso ye-HPMC eneqondo eliphantsi lokutshintshwa. Oku kuya kwandisa inani lamaqela e-hydroxyl akhoyo kwikhonkco le-polymer, eliya kuphucula ukunyibilika kwayo. Ukongezelela, kubalulekile ukusebenzisa i-solvent efanelekileyo kwaye uqinisekise ukuba ikwiqondo lokushisa elichanekileyo kunye ne-pH. Ukuba ukunyibilika kwe-HPMC kusekubi, kunokuba yimfuneko ukusebenzisa i-surfactant okanye enye iarhente yokunyibilikisa.

3. Ukungahambelani nabanye abancedisi

I-HPMC isoloko isetyenziswa ngokudityaniswa nabanye abancedisi ukuphucula ukusebenza kunye neempawu zemveliso yokugqibela. Nangona kunjalo, ezinye ii-excipients zinokungahambelani ne-HPMC, ezikhokelela kwiingxaki ezifana nokuhlukana kwesigaba, ukubunjwa kwejel, okanye utshintsho kwi-viscosity.

Isisombululo: Ukunqanda imiba yokungahambelani, kubalulekile ukuvavanya ukuhambelana kwe-HPMC kunye nabanye abancedisi phambi kokusetyenziswa. Oku kunokwenziwa ngokulungiselela ukuqulunqwa okuncinci kunye nokuqwalasela naluphi na utshintsho kwimbonakalo, i-viscosity, okanye ezinye iimpawu. Ukuba ukungahambisani kufunyenwe, kunokuba yimfuneko ukulungisa ukuqulunqwa okanye ukusebenzisa i-excipient eyahlukileyo.

4. Ukungaphumeleli ukwenza ifilimu

I-HPMC isoloko isetyenziswa njenge-arhente yokugquma iipilisi kunye ne-capsules ukuphucula inkangeleko yazo, ukuzinza, kunye nokuginya. Nangona kunjalo, isakhono sokwenza ifilimu ye-HPMC sinokuchatshazelwa zizinto ezinjengokufuma