Yenza ijeli yeSanitizer yesandla usebenzisa iHPMC ukuze ubuyisele iCarbomer
Ijeli yesanitizer yesandla ibe yinto ebalulekileyo kubomi bethu bemihla ngemihla, ngakumbi ngexesha lobhubhani we-COVID-19. Into esebenzayo kwijeli yesanitizer yesandla butywala, obusebenza ngokubulala iintsholongwane kunye neentsholongwane ezandleni. Nangona kunjalo, ukwenza i-gel formulation, i-ejenti yokuqina iyafuneka ukudala i-gel-stable-like consistency. ICarbomer sisixhobo sokutyebisa esiqhele ukusetyenziswa kwijeli yesanitizer yesandla, kodwa kunokuba nzima ukuyikhupha kwaye ibone ukunyuka kwamaxabiso ngenxa yobhubhane. Kweli nqaku, siza kuxoxa ngendlela yokwenza ijeli yesanitizer yesandla usebenzisa iHydroxypropyl Methylcellulose (HPMC) njengendawo yokutshintsha i-carbomer.
IHydroxypropyl Methylcellulose (HPMC) iphuma kwi cellulose enoluhlu olubanzi lwezicelo, kubandakanywa njenge-thickener, binder, kunye ne-emulsifier. I-HPMC yipolima enyibilikayo emanzini enokuthi ijiye imixube esekwe emanzini, iyenze ibe yeyona ndlela ifanelekileyo kwi-carbomer kwimixube yejeli yesanitizer ngesandla. I-HPMC ikwafumaneka ngokulula kwaye ineendleko ezingaphezulu kune-carbomer, iyenza ibe yenye enomtsalane kubavelisi.
Ukwenza ijeli yesanitizer yesandla usebenzisa iHPMC, ezi zithako zilandelayo kunye nezixhobo ziyafuneka:
Izithako:
- Isopropyl utywala (okanye i-ethanol)
- Ihydrogen peroxide
- IGlycerin
- IHydroxypropyl Methylcellulose (HPMC)
- Mamanzi amisiwe
Izixhobo:
- Isitya sokuxuba
- Ukuxuba intonga okanye umxube wombane
- Ukulinganisa iikomityi kunye namacephe
- imitha ye-pH
- Isikhongozeli sokugcina ijeli yesicoci sesandla
Inyathelo 1: Linganisa izithako Linganisa ezi zithako zilandelayo:
- I-Isopropyl alcohol (okanye i-ethanol): i-75% yomthamo wokugqibela
- I-hydrogen peroxide: i-0.125% yomthamo wokugqibela
- I-Glycerin: i-1% yomthamo wokugqibela
- I-HPMC: 0.5% yomthamo wokugqibela
- Amanzi adibeneyo: umthamo oseleyo
Umzekelo, ukuba ufuna ukwenza i-100ml yejeli yesicoci sesandla, kuya kufuneka ulinganise:
- Isopropyl utywala (okanye i-ethanol): 75ml
- Iperoxide yehidrojeni: 0.125ml
- IGlycerin: 1ml
- I-HPMC: 0.5ml
- Amanzi adibeneyo: 23.375ml
Inyathelo lesi-2: Xuba Izithako Xuba i-isopropyl alcohol (okanye i-ethanol), i-hydrogen peroxide, kunye ne-glycerin ndawonye kwisitya sokuxuba. Gxuma umxube de udibaniswe kakuhle.
Inyathelo 3: Yongeza HPMC Kancinci yongeza i-HPMC kumxube ngelixa uvuselela ngokuqhubekayo. Kubalulekile ukongeza i-HPMC ngokucothayo ukunqanda ukuhlangana. Qhubeka uvuselela de i-HPMC ihlakazwe ngokupheleleyo kwaye umxube ugudile.
Inyathelo lesi-4: Yongeza Amanzi Yongeza amanzi adibeneyo kumxube ngelixa uvuselela ngokuqhubekayo. Qhubeka uvuselela de umxube udityaniswe kakuhle.
Inyathelo lesi-5: Jonga i-pH Jonga i-pH yomxube usebenzisa imitha ye-pH. I-pH kufuneka ibe phakathi kwe-6.0 kunye ne-8.0. Ukuba i-pH iphantsi kakhulu, yongeza inani elincinci le-sodium hydroxide (NaOH) ukulungisa i-pH.
Inyathelo lesi-6: Hlanganisa kwakhona Vuselela umxube kwakhona ukuqinisekisa ukuba zonke izithako zidityanisiwe.
Inyathelo lesi-7: Dlulisela kwisikhongozeli Hambisa ijeli yesicoci sesandla kwisingxobo ukuze sigcinwe.
Ijeli ye-sanitizer yesandla enesiphumo kufuneka ibe ne-smoolise, efana nejeli ekulula ukuyisebenzisa ezandleni. I-HPMC isebenza njenge-thickener kwaye idala i-gel-stable-like consistency, efana ne-carbomer. Ijeli yesanitizer yesandla enesiphumo kufuneka isebenze ekubulaleni ibhaktheriya kunye neentsholongwane ezandleni, njengejeli zesanitizer ezifumanekayo kurhwebo.
izenzo zokuvelisa (GMP) yiseti yezikhokelo kunye nemigaqo eqinisekisa umgangatho kunye nokhuseleko lweemveliso zamachiza, kubandakanywa nejeli ye-sanitizer yesandla. Ezi zikhokelo zibandakanya imiba eyahlukeneyo yenkqubo yokuvelisa, kubandakanywa abasebenzi, indawo, izixhobo, amaxwebhu, imveliso, ulawulo lomgangatho, kunye nokuhanjiswa.
Xa usenza ijeli yesanitizer yesandla usebenzisa i-HPMC okanye nayiphi na enye iarhente etyebisayo, kubalulekile ukulandela izikhokelo ze-GMP ukuqinisekisa umgangatho kunye nokhuseleko lwemveliso. Eminye yemigaqo ye-GMP ephambili ekufuneka ilandelwe xa kusenziwa ijeli yesanitizer yesandla ibandakanya:
- Abasebenzi: Bonke abasebenzi ababandakanyekayo kwinkqubo yokuvelisa kufuneka baqeqeshwe ngokufanelekileyo kwaye bafanelekele iindima zabo. Kufuneka kwakhona bazazi izikhokelo ze-GMP kwaye bazilandele ngokungqongqo.
- Indawo: Indawo yokuvelisa kufuneka icoceke, igcinwe kakuhle, kwaye iyilelwe ukuthintela ukosuleleka. Esi sakhiwo kufuneka sixhotyiswe ngendlela efanelekileyo yokungenisa umoya kunye nezibane, kwaye zonke izixhobo kufuneka zilinganiswe ngokufanelekileyo kwaye ziqinisekiswe.
- Izixhobo: Zonke izixhobo ezisetyenziswa kwinkqubo yokuvelisa kufuneka zicocwe rhoqo kwaye zigcinwe ukuthintela ukungcoliseka. Izixhobo kufuneka ziqinisekiswe ukuqinisekisa ukuba zisebenza ngokuchanekileyo kwaye zivelisa iziphumo ezifanayo.
- Amaxwebhu: Zonke iinkqubo zokuvelisa kufuneka zibhalwe ngokufanelekileyo, kubandakanywa neerekhodi zebhetshi, iinkqubo zokusebenza eziqhelekileyo (ii-SOPs), kunye neerekhodi zokulawula umgangatho. Amaxwebhu kufuneka acokiseke kwaye achaneke ukuqinisekisa ukulandeleka kunye nokuphendula.
- Imveliso: Inkqubo yokuvelisa kufuneka ilandele inkqubo echaziweyo kunye neqinisekisiweyo eqinisekisa umgangatho ohambelanayo kunye nokucoceka kwemveliso. Zonke izinto ezisetyenziselwa inkqubo yokuvelisa kufuneka zichongwe ngokufanelekileyo, ziqinisekiswe, kwaye zigcinwe.
- Ulawulo lomgangatho: Imilinganiselo yolawulo lomgangatho kufuneka ibekwe ukuze kuqinisekiswe ukuba imveliso yokugqibela iyahlangabezana nemigaqo efunekayo. Ulawulo lomgangatho kufuneka lubandakanye uvavanyo lwesazisi, ukucoceka, amandla, kunye nezinye iiparamitha ezifanelekileyo.
- Ukuhanjiswa: Imveliso egqityiweyo kufuneka ipakishwe ngokufanelekileyo, ibhalwe, kwaye igcinwe ukunqanda ukungcoliseka kunye nokugcina ingqibelelo yayo. Inkqubo yokuhambisa kufuneka ibhalwe ngokufanelekileyo, kwaye zonke izinto ezithunyelwayo kufuneka zilandelelwe ngokufanelekileyo kwaye zibekwe esweni.
Ngokulandela ezi zikhokelo ze-GMP, abavelisi banokuqinisekisa ukuba iimveliso zabo zejeli ye-sanitizer yezandla zikumgangatho ophezulu kwaye zikhuselekile ukuba zingasetyenziswa. Ezi zikhokelo zikwanceda ekuqinisekiseni ukungaguquguquki kunye nokuthembeka kwinkqubo yokwenziwa kwemveliso, eyimfuneko ukuze kuhlangatyezwane nemfuno ekhulayo yejeli yesanitizer yesandla ngexesha lobhubhani we-COVID-19.
Ukuqukumbela, i-Hydroxypropyl Methylcellulose (HPMC) ingasetyenziselwa indawo ye-carbomer kwimiqulu yejeli ye-sanitizer yesandla. I-HPMC yindlela engabiziyo kwaye efumaneka lula enokubonelela ngeempawu zokujiya ezifanayo kwi-carbomer. Xa usenza ijeli yesanitizer yesandla usebenzisa i-HPMC, kubalulekile ukulandela izikhokelo ze-GMP ukuqinisekisa umgangatho kunye nokhuseleko lwemveliso. Ngokulandela ezi zikhokelo, abavelisi banokuvelisa ijeli yesanitizer yesandla esebenzayo ekubulaleni ibhaktheriya kunye neentsholongwane ezandleni, ngelixa beqinisekisa ukhuseleko lomsebenzisi wokugqibela.
Ixesha lokuposa: Mar-18-2023