I-Hydroxypropyl methylcellulose isetyenziswa kwiipilisi

IHydroxypropyl methylcellulose (HPMC) yinto eqhelekileyo esetyenziswa kumayeza, kubandakanywa neepilisi. I-HPMC yipolymer esekwe kwi-cellulose enyibilikayo emanzini kwaye ineempawu ezahlukeneyo ezenza ukuba ibe luncedo kwi-tablet formulations. Eli nqaku liza kuxoxa ngeempawu ze-HPMC kunye nokusetyenziswa kwayo okwahlukeneyo kwimveliso yethebhulethi.

Iipropati ze-HPMC:

I-HPMC yipolymer eyihydrophilic enokusetyenziswa njengesibophelelo, isingqimba, isizinzisi, kunye ne-emulsifier. Inobunzima be-molecular kunye neqondo eliphezulu lokutshintshwa (DS), elichaphazela ukunyibilika kwayo kunye ne-viscosity. I-HPMC inokunyibilika emanzini okanye etywaleni, kodwa ayinyibiliki kwizinyibilikisi ezininzi zezinto eziphilayo. Kananjalo ayinayo ityhefu, ayicaphukisi, kwaye ayinayo i-allergenic, iyenza ibe lolona khetho lufanelekileyo kwizicelo zamayeza.

Ukusetyenziswa kwe-HPMC kwiipilisi:

1. Isibophelelo:

I-HPMC iqhele ukusetyenziswa njengesibophelelo kwimixube yethebhulethi. Yongezwa kwi-tablet granules ukubamba kunye kunye nokukhusela ukuba bangawa. I-HPMC ingasetyenziswa yodwa okanye idityaniswe nezinye izibophelelo, ezifana ne-microcrystalline cellulose (MCC), ukuphucula ubulukhuni bethebhulethi kunye nokuqina.

2. Disintegrant:

I-HPMC isenokusetyenziswa njenge-disintegrant kwi-tablet formulations. I-Disintegrants yongezwa kwiipilisi ukubanceda ukuba bahlukane kwaye bachithe ngokukhawuleza kwi-gastrointestinal tract. I-HPMC isebenza njenge-disintegrant ngokudumba emanzini kunye nokudala imijelo ukuze amanzi angene kwithebhulethi. Oku kunceda ukwahlula ithebhulethi kunye nokukhulula isithako esisebenzayo.

3. Ukhupho olulawulwayo:

I-HPMC isetyenziselwa ukulawulwa-ukukhutshwa kwe-tablet formulations ukulawula ukukhutshwa kwesithako esisebenzayo. I-HPMC yenza umaleko wejeli ejikeleze ithebhulethi, elawula ukukhutshwa kwesithako esisebenzayo. Ubuninzi be-gel layer bunokulawulwa ngokutshintsha i-DS ye-HPMC, echaphazela i-viscosity kunye ne-solubility ye-polymer.

4. Ukugquma ifilimu:

I-HPMC iphinda isetyenziswe njenge-arhente yokugquma ifilimu ekuqulunqweni kwethebhulethi. Ukufakwa kwefilimu yinkqubo yokufaka umaleko obhityileyo wepolymer kumphezulu wethebhulethi ukuphucula inkangeleko yayo, uyikhusele kubumanzi, kwaye uyigqume incasa yayo. I-HPMC ingasetyenziselwa yodwa okanye idibaniswe namanye ama-agent e-coating-coating agents, njenge-polyethylene glycol (PEG), ukuphucula iipropati zokwenza ifilimu yokugqoka.

5. Iarhente yokunqumamisa:

I-HPMC ikwasetyenziswa njenge-arhente yokunqunyanyiswa kwimixube engamanzi. Ingasetyenziselwa ukumisa amasuntswana anganyibilikiyo kulwelo ukwenza ukunqunyanyiswa okuzinzileyo. I-HPMC isebenza ngokwenza umaleko okhuselayo ojikeleze amasuntswana, ukuthintela ukuba agglomerating kunye nokuhla ezantsi kwesikhongozeli.

Isiphelo:

IHydroxypropyl methylcellulose yipolymer eguquguqukayo eneendlela ezahlukeneyo zokusetyenziswa kwimiqulu yethebhulethi. Ingasetyenziswa njenge-binder, i-disintegrant, i-agent-release-release agent, i-agent-coating agent, kunye ne-agent yokumiswa. Iipropati zayo ezingenayo ityhefu, ezingacaphukiyo, kunye ne-non-allergenic zenza ukuba kube yinto efanelekileyo yokusetyenziswa kwamachiza. Iipropati ze-HPMC zinokulungelelaniswa ngokutshintsha iqondo lokutshintshwa, okwenza ukuba i-polymer eguquguqukayo enokuthi isetyenziswe kwiintlobo ezahlukeneyo ze-tablet formulations.