I-Hydroxypropyl methylcellulose yi-ether ephawulekayo ye-nonionic edibeneyo ye-cellulose eye yaguqula imboni yeekhemikhali. I-polymer yenziwe ngokuguqula i-cellulose yendalo efunyenwe kumthi okanye ikotoni. I-HPMC isetyenziswa ikakhulu kwiintlobo ngeentlobo zezicelo ngenxa yeempawu zayo ezibalaseleyo ezibandakanya ukutyeba, ukunqumamisa, ukuthambisa, ukuthambisa kunye nokugcinwa kwamanzi.
Ukongeza, ii-HPMCs zinolawulo oluhle kakhulu malunga nokukhutshwa kwezithako ezisebenzayo kwiindlela ezahlukeneyo zamachiza, kubandakanywa iipilisi, iipilisi, i-ointments, kunye neegels. Ngokucoceka kwayo okuphezulu kunye ne-biocompatibility egqwesileyo, i-HPMC ihlangabezana neyona migangatho iphezulu yamachiza, iphucula umgangatho kunye nokusebenza kakuhle kwamachiza.
Ubume be-HPMC be-non-ionic buyenza ibe lolona khetho lubalaseleyo kumashishini ahlukeneyo aquka ukutya, izithambiso kunye nolwakhiwo. Njenge-thickener yokongeza ukutya, i-HPMC inokuphucula ukuthungwa kunye nokuzinza kokutya okucutshungulwayo, ngelixa kwishishini lokuthambisa, lidlala indima ebalulekileyo njenge-binder, emulsifier kunye ne-thickener. Ekwakhiweni, i-HPMC ingasetyenziselwa njenge-arhente yokugcina amanzi, iglue kunye ne-thickener ukuphucula ukunamathela, ukuqina kunye namandla ezinto zokwakha.
Ukusebenza okugqwesileyo kwe-HPMC kubangelwa kukwaziswa kwe-hydroxypropyl kunye namaqela e-methyl kumqolo we-cellulose. Amaqela e-Hydroxypropyl (HP) anoxanduva lokunyusa ukunyibilika, ngelixa amaqela e-methyl anciphisa ukuhlangana kwe-hydrogen kunye nokuphucula ukunyibilika kwamanzi. Iqondo lokutshintshwa kwe-HP kunye namaqela e-methyl kwi-HPMC ibalulekile ekumiseleni iimpawu zayo, kuquka i-viscosity kunye ne-solubility.
I-HPMC licandelo elibalulekileyo leenkqubo zokuhanjiswa kweziyobisi ezilawulwayo. Kwezi nkqubo, ii-HPMCs zonyusa ukukhutshwa kwechiza ngendlela elawulwayo, iqinisekisa ukusebenza kakuhle konyango, ukonyuka kwe-bioavailability kunye neziphumo ebezingalindelekanga ezincitshisiweyo. I-polymer inokuthi yenziwe ibe yithebhulethi ye-matrix, eneempawu zokukhululwa okuqhubekayo, ezivumela ukuba ichiza likhutshwe emzimbeni ixesha elide.
Enye yeenzuzo eziphambili ze-HPMC kukuhambelana kwayo kwezinto eziphilayo. Le propati yenza ukuba ibe luncedo ekuqulunqweni kwamachiza ekulawuleni ngomlomo kuba ikhuselekile, ayinayo ityhefu kwaye ingasebenzi kunye nezicubu zomzimba. Ukongeza, i-HPMC ineempawu ezintle kakhulu zokwenza ifilimu kwaye ifanelekile ukugquma iipilisi, iipilisi kunye neegranules.
I-HPMC yipolymer eyodwa esebenzayo enokuthi isetyenziswe kwizicelo ezahlukeneyo ezibandakanya amayeza, izithambiso, ukutya kunye nokwakhiwa. Iimpawu zayo ezikhethekileyo, kubandakanywa ukuqina, ukumisa kunye nokugcinwa kwamanzi, kwenza kube enye yezona zinto zibalulekileyo ekubunjweni kwanamhlanje. Ngokunyibilika kwazo okugqwesileyo, ukuhambelana kwezinto eziphilayo, kunye nesakhono sokukhululwa esilawulwayo, ii-HPMCs ziye zaguqula ishishini lokuhanjiswa kweziyobisi, ukuphucula ukusebenza kweziyobisi, ukhuseleko kunye nomgangatho. Akukho mathandabuzo ukuba i-HPMC iya kuqhubeka ukudlala indima ebalulekileyo kwishishini lemichiza.
Ixesha lokuposa: Sep-08-2023