I-Hydroxypropylmethylcellulose (HPMC) yi-multifunctional molecular compound esetyenziswe ngokubanzi kwishishini lokwakha. Isetyenziswa ngokubanzi kwizicelo ze-putty njengoko iphucula ukusebenza ngokubanzi kunye nomgangatho weputty. Kweli nqaku, siza kuphonononga ukusetyenziswa kwe-HPMC kwi-putty, sihlalutye iingxaki ezinokuvela ngexesha lokusetyenziswa kwayo, kwaye sabelane ngeengcebiso malunga nendlela yokuphepha ezi ngxaki.
Okokuqala, makhe sijonge ngakumbi kwiimpawu ze-HPMC. Yi-nonionic cellulose ether, enyibilikayo emanzini kunye nezinye izinyibilikisi eziphilayo. Ubume bayo obukhethekileyo be-molecular bunika i-viscosity egqwesileyo, ukugcinwa kwamanzi kunye neempawu zokubambelela. Ke ngoko, sisongezo esifanelekileyo kwizicelo ze-putty.
I-HPMC ingasetyenziswa njenge-thickener, binder kunye ne-emulsifier kwi-putty formulations. Inokugcinwa kwamanzi okugqwesileyo okunceda ukukhusela i-putty ukuba yome ngokukhawuleza. Kwakhona kwandisa ukunamathela kwe-putty kwi-substrate, iyenze ibe yinto ehlala ixesha elide. Ezi zakhiwo zenza i-HPMC ibe yinto ebalulekileyo kwiiputty ezikumgangatho ophezulu.
Nangona kunjalo, ezinye iingxaki zinokuthi zenzeke xa i-HPMC isetyenziswa kwi-putty. Ingxaki yokuqala kukuba i-HPMC inovelwano kwi-pH kunye notshintsho lobushushu. Ukuba i-pH ye-putty formulation i-acidic kakhulu, inokubangela ukuba i-HPMC ilahlekelwe yi-viscosity. Ngexesha elifanayo, ukuba ukushisa kuphezulu kakhulu, kuya kubangela ukuba i-HPMC ihlaziywe, eya kuchaphazela ukusebenza kwe-putty.
Enye ingxaki enokuthi ivele kukuqumba. Ukuba i-HPMC ayixutywanga kakuhle kunye nezinye izithako kwifomula ye-putty, inokwenza i-clumps okanye i-clumps. Ezi zigaqa zichaphazela umgangatho we-putty, okwenza kube lula kwaye kube nzima ukuyifaka.
Ukuphepha ezi ngxaki, eminye imigaqo esisiseko kufuneka ilandelwe xa usebenzisa i-HPMC kwizicelo zePutty. Okokuqala, kuyimfuneko ukukhetha uhlobo olufanelekileyo lwe-HPMC kwi-putty formulation. Iindidi ezahlukeneyo ze-HPMC zinokuba neempawu ezahlukeneyo, ngoko ke uhlobo oluchanekileyo kufuneka lukhethwe kwisicelo esithile.
Okwesibini, kubalulekile ukuxuba ngokucokisekileyo i-HPMC kunye nezinye izithako kwi-putty formulation. Oku kuya kunceda ukuthintela amaqhuma okanye amaqhuma. Kwakhona kubalulekile ukusebenzisa inkqubo yokuxuba echanekileyo ukuqinisekisa ukuba i-putty ixutywe kakuhle.
Okwesithathu, nikela ingqalelo kwi-pH kunye nobushushu be-putty formula. Kubalulekile ukuqinisekisa ukuba i-pH ingaphakathi koluhlu olucetyiswayo kuhlobo oluthile lwe-HPMC olusetyenziswayo. Kwakhona kubalulekile ukubeka esweni ubushushu bokwenziwa kwaye bugcinwe ngaphakathi koluhlu olucetyiswayo ukuthintela ukuthotywa kwe-HPMC.
Isishwankathelo, i-HPMC sisithako esibalulekileyo kwimixube ye-putty ekumgangatho ophezulu. Inika ukugcinwa kwamanzi okugqwesileyo, ukunamathela kunye neempawu ze-viscosity ezinokuphucula ukusebenza ngokubanzi kunye nomgangatho weeputty. Nangona kunjalo, ezinye iingxaki zinokuthi zenzeke ngexesha lokusetyenziswa kwayo, ezifana novelwano kwi-pH kunye nokutshintsha kweqondo lokushisa, i-caking, njl. Ngokulandela imigaqo ethile esisiseko xa usebenzisa i-HPMC, ezi ngxaki zinokuphetshwa kwaye i-putty ephezulu inokufumaneka.
Ixesha lokuposa: Jul-27-2023