IHydroxypropylmethylcellulose (HPMC) yi-ether yeselulosi esetyenziswa kakhulu kumashishini aliqela afana namayeza, izinto zokuthambisa, ukutya, kunye nokwakha. Ngenxa yokuguquguquka kwayo kunye neepropathi eziluncedo, i-HPMC iye yaba sisithako esidumileyo kwimixube eyahlukeneyo. Okwangoku, kukho iindidi ezininzi ze-HPMCs kwimarike, nganye ineempawu ezizodwa kunye nokusetyenziswa.
I-HPMC yi-chemically modified cellulose polymer efunyenwe ngokusabela i-cellulose nge-methyl chloride kunye ne-propylene oxide. Le mpendulo yazisa amaqela e-methyl kunye ne-hydroxypropyl kwisakhiwo se-cellulose, ukwenza i-polymer e-soluble yamanzi, engekho i-ionic kunye ne-high-performance polymer. Nangona kunjalo, iintlobo ezahlukeneyo ze-HPMC zinemigangatho eyahlukeneyo yokutshintsha (DS) yamaqela e-methyl kunye ne-hydroxypropyl, emisela iimpawu zabo zomzimba kunye neekhemikhali.
Ngokubanzi, iimveliso ze-HPMC zihlelwa ngokwe-viscosity kunye nexabiso le-DS. I-Viscosity yipropathi ebalulekileyo ye-HPMC njengoko ichaphazela ukunyibilika kwemveliso, ukukwazi ukwenza ifilimu kunye nokukwazi ukujiya. Kwelinye icala, ixabiso le-DS limisela iqondo lokutshintshwa kwepolymer kwaye ngaloo ndlela iqondo le-hydrophobicity yohlobo lwe-HPMC. Ke ngoko, iintlobo ezahlukeneyo ze-HPMC zithathwe ngokutshintshana kwe-viscosity yazo kunye namaxabiso e-DS. Ngezantsi zezona ntlobo zixhaphakileyo ze-HPMC kunye nendlela eyahluke ngayo.
1. Ibakala eliqhelekileyo HPMC
Ibakala eliqhelekileyo le-HPMC line-methyl DS ukusuka kwi-0.8 ukuya kwi-2.0 kunye ne-hydroxypropyl DS ukusuka kwi-0.05 ukuya kwi-0.3. Olu hlobo lwe-HPMC lufumaneka kuluhlu olubanzi lwamabakala e-viscosity ukusuka kwi-3cps ukuya kwi-200,000cps. Ibakala eliqhelekileyo le-HPMC linokunyibilika okulungileyo emanzini kwaye lifake izisombululo ezicacileyo, okwenza ukuba zilungele izicelo ezahlukeneyo kumashishini okutya, amayeza kunye nezithambiso. Ezo HPMCs ziqhele ukusetyenziswa njengeefilim, ezityebileyo, ii-emulsifiers kunye nezizinzisi ekutyeni nakwizinto zokuthambisa.
2. Ukutshintshwa okuphantsi kwe-HPMC
I-HPMC efakwe endaweni ephantsi ineqondo elisezantsi le-methyl kunye ne-hydroxypropyl endaweni ye-HPMC yebakala eliqhelekileyo. Olu hlobo oluthile lwe-HPMC lune-methyl DS ukusuka kwi-0.2 ukuya kwi-1.5 kunye ne-hydroxypropyl DS ukusuka kwi-0.01 ukuya kwi-0.2. Ukutshintshwa okuphantsi kweemveliso ze-HPMC zine-viscosity ephantsi, ngokuqhelekileyo phakathi kwe-3-400cps, kwaye zixhathisa kakhulu kwityuwa kunye ne-enzymes. Ezi zakhiwo zenza indawo ephantsi ye-HPMC ilungele iimveliso zokutya ezifana nobisi, indawo yokubhaka kunye neemveliso zenyama. Ukongeza, i-HPMC efakwe endaweni ephantsi ikwasetyenziswa njenge-binder, i-disintegrant kunye ne-ejenti yokwambathisa ithebhulethi kushishino loxubo mayeza.
3. High replacement HPMC
Iqondo eliphezulu lokutshintsha i-HPMC ineqondo eliphezulu le-methyl kunye ne-hydroxypropyl endaweni ye-HPMC yebakala eliqhelekileyo. Olu hlobo lwe-HPMC lune-methyl DS ukusuka kwi-1.5 ukuya kwi-2.5 kunye ne-hydroxypropyl DS ukusuka kwi-0.1 ukuya kwi-0.5. Iimveliso ezifakwe endaweni ephezulu ye-HPMC zine-viscosity ephezulu, ukusuka kwi-100,000cps ukuya kwi-200,000cps, kwaye zinezakhiwo ezinamandla zokugcina amanzi. Ezi propati zenza i-HPMC efakwe endaweni ephezulu ilungele ukusetyenziswa kwicandelo lolwakhiwo, njengeemveliso ezisekwe kwisamente, iingubo kunye nezinto ezincamathelayo. I-HPMC efakwe endaweni ephezulu ikwasetyenziswa njenge-binder, i-thickener kunye ne-arhente yokukhulula kwishishini loxubo-mayeza.
4. I-Methoxy-Ethoxy HPMC
I-Methoxy-Ethoxy HPMC luhlobo oluyilwe ngokukodwa lwe-HPMC kunye neqondo eliphezulu lokutshintshwa kwe-ethoxy. Amaqela ethoxy kwandisa hydrophobicity of HPMC, iyenza ibe ngaphantsi ukunyibilika emanzini ngaphezu grade HPMC eqhelekileyo. Nge-methyl DS ukusuka kwi-1.5 ukuya kwi-2.5 kunye ne-ethoxy DS ukusuka kwi-0.4 ukuya kwi-1.2, i-methoxy-ethoxy HPMC ilungele ukusetyenziswa kwiimveliso ezisekelwe kwioli ezifana nezithambiso, iipende kunye neengubo. Olu hlobo lwe-HPMC lwenza ifilimu ezinzileyo kunye neyunifomu ebonelela ngokugudileyo, ukugqibezela okukhazimlayo kwimveliso yokugqibela.
5. Granular HPMC
IGranular HPMC luhlobo lwe-HPMC enobungakanani besuntswana elincinci, ngokuqhelekileyo phakathi kwe-100-200 microns. I-HPMC yeGranular isetyenziswa kwishishini lamachiza njenge-tablet binder, i-disintegrant kunye ne-arhente yokukhululwa eqhubekayo. Ubungakanani be-particle encinci ye-HPMC ivumela ukuhanjiswa ngokulinganayo kwezithako, okukhokelela kwimveliso ehambelanayo nethembekileyo. I-HPMC yeGranular ine-methyl DS ukusuka kwi-0.7 ukuya kwi-1.6 kunye ne-hydroxypropyl DS ukusuka kwi-0.1 ukuya kwi-0.3.
I-Hydroxypropylmethylcellulose (HPMC) i-polymer esebenzayo kunye noluhlu olubanzi lwezicelo kumashishini ahlukeneyo. Iintlobo ze-HPMC zihlelwa ngokwe-viscosity kunye nexabiso le-DS, elimisela iimpawu zabo zomzimba kunye neekhemikhali. HPMC grade rhoqo, endaweni ephantsi HPMC, endaweni ephezulu HPMC, methoxyethoxy HPMC kunye HPMC granular zezona ntlobo zixhaphakileyo HPMC. Ukuqonda umahluko phakathi kwezi ntlobo kuya kuvumela abaqulunqi ukuba basebenzise amandla apheleleyo e-HPMCs ukuvelisa umgangatho ophezulu kunye neemveliso zokuphela ezinamandla.
Ixesha lokuposa: Sep-06-2023