IHydroxypropylmethylcellulose (HPMC) yipolymer eyenziweyo evela kwiselulosi. Njenge-thickener, emulsifier kunye ne-stabilizer, isetyenziswa kakhulu kumayeza, ukutya kunye namashishini okuthambisa. I-HPMC ikwasetyenziswa kwizinto zokwakha ezifana nesamente, udaka kunye negypsum ukuphucula ukusebenza kunye nokugcinwa kwamanzi. Kweli nqaku, siza kuxubusha ukuveliswa kwe-HPMC kunye nokusetyenziswa kwayo kumashishini ahlukeneyo.
Imveliso ye-HPMC
I-HPMC idityaniswe ngokuphendula i-cellulose nge-propylene oxide kunye ne-methyl chloride phantsi kweemeko ze-alkaline. Inkqubo ibandakanya la manyathelo alandelayo:
Inyathelo 1: Unyango lwe-alkaline ye-cellulose
I-cellulose iphathwa ngesisombululo se-caustic se-sodium hydroxide ukuyiguqula kwi-alkaline cellulose. Olu nyango lwenza amaqela e-hydroxyl e-cellulose asebenze ngakumbi, aququzelele ukusabela okulandelayo.
Inyathelo lesi-2: Ukuphendula ngePropylene oxide
Kwisinyathelo esilandelayo, i-propylene oxide yongezwa kwi-cellulose ye-alkali phantsi kobushushu obulawulwayo kunye neemeko zoxinzelelo. Ukusabela kuqhutyelwa phambi kwe-catalyst efana ne-amine ephezulu okanye i-alkali metal hydroxide. Ipropylene oxide idibana kunye namaqela e-hydroxyl yeselulosi ukwenza i-hydroxypropyl cellulose.
Inyathelo lesi-3: Ukwenziwa kweQuaternization ngeMethyl Chloride
IHydroxypropylcellulose emva koko yafakwa iquaternized kunye nemethyl chloride ukuvelisa iHPMC. Ukusabela kuqhutyelwa phantsi kweemeko ze-alkaline, kwaye iqondo le-quaternization lingalawulwa ngokulungelelanisa inani le-methyl chloride.
Isiphumo se-HPMC sahlanjwa, sahluzwa kwaye somiswa ukuze sifumane umgubo omhlophe, okhululekileyo. Iipropati ze-HPMC, ezifana ne-viscosity, i-solubility, kunye neempawu ze-gel, zinokulungiswa ngokutshintsha i-degree of substitution (DS) ye-hydroxypropyl kunye namaqela e-methyl.
Ukusetyenziswa kwe-HPMC
I-HPMC inoluhlu olubanzi lwezicelo kumashishini ahlukeneyo. Ezinye izicelo eziphawulekayo zixoxwa ngezantsi:
Ishishini lamachiza
I-HPMC isetyenziswa kakhulu kushishino loxubo mayeza njengento etyebisayo, ibhinda kunye nefilimu yangaphambili. Isetyenziswe kwi-tablet formulations ukulawula ukukhutshwa kweziyobisi. I-HPMC isebenza njengesibophelelo ngokucinezela umxube womgubo kwifomu yedosi eqinileyo. Kwakhona kuphucula ukunyibilika kunye ne-bioavailability yamachiza anganyibiliki kakuhle ngokwenza i-dispersions ezinzileyo kunye efanayo.
ishishini lokutya
I-HPMC isetyenziswa kushishino lokutya njenge-emulsifier, i-thickener kunye ne-stabilizer. Isetyenziswa ngokuqhelekileyo kwiimveliso zokubhaka, i-ayisikrimu kunye neemveliso zobisi. I-HPMC iphucula ukuthungwa kunye nokuhambelana kokutya ngokuthintela ukuhlukana kwezithako kunye nokunciphisa i-syneresis. Ikwaphucula incasa kunye nobomi beshelufa yokutya.
Ishishini lezithambiso
I-HPMC isetyenziswa kushishino lwezithambiso njenge-thickener kunye ne-emulsifier. Isetyenziswa kwiimveliso zokhathalelo lwesikhumba kunye neenwele ezifana nezithambiso, iikhrimu, iishampu kunye nezipholileyo. I-HPMC iphucula ukuthungwa kunye nokungaguquguquki kwezi mveliso kwaye ibonelela ngokufuma kunye nezibonelelo zokumisela.
ishishini lokwakha
I-HPMC isetyenziswa kushishino lokwakha njengokongeza kwisamente, udaka kunye negypsum. Iphucula ukusebenza kunye nokugcinwa kwamanzi kwezi zixhobo, ngaloo ndlela ukwandisa amandla abo kunye nokuqina. I-HPMC ikwanciphisa umngcipheko wokuqhekeka kunye nokuncipha ngexesha lokumisa.
ukuququmbela
Ukuqukumbela, i-HPMC yipolymer eguquguqukayo neguquguqukayo enezicelo kumashishini ahlukeneyo. Ilungiswa ngonyango lwe-alkali ye-cellulose, ukuphendula nge-propylene oxide, kunye ne-quaternization nge-methyl chloride. Iipropati ze-HPMC zinokulungiswa ngokutshintsha iqondo lokuthatha indawo. I-HPMC idlala indima ebalulekileyo kumashishini amayeza, ukutya, izithambiso kunye nokwakha ngokuphucula ukuthungwa, ukuhambelana kunye nokusebenza kweemveliso ezahlukeneyo. I-non-toxicity yayo kunye ne-biocompatibility yenza ukuba ibe yinto ekhuselekileyo nexabisekileyo kula mashishini.
Ixesha lokuposa: Aug-03-2023