Izinto ezichaphazela i-viscosity ye-hydroxypropyl methylcellulose

IHydroxyl methyl cellulose (HPMC) yipolymer esetyenziswa kakhulu kumachiza, izithambiso, ukutya kunye namanye amashishini. Iimpawu zayo ezizodwa, ezifana ne-viscosity ephezulu, i-soluble yamanzi -i-soluble kunye ne-membrane yokwakheka isakhono, okwenza kube yinto ebalulekileyo kwiifomyula ezahlukeneyo. I-viscosity yinto ephambili ye-HPMC kwisicelo sayo. I-viscosity ye-HPMC ichatshazelwa yimiba eyahlukeneyo, efana noxinzelelo, ubushushu, i-pH, kunye nobunzima bemolekyuli. Ukuqonda izinto ezichaphazela i-HPMC viscosity kubalulekile ekuphuculeni. Eli nqaku lixoxa ngezinto ezichaphazela i-viscosity ye-hydroxylopyl methyl cellulose.

Jongisisa i

Ukugxininiswa kwe-HPMC yenye yezinto eziphambili ezichaphazela i-viscosity yayo. I-viscosity yesisombululo se-HPMC iyanda ngokunyuka koxinzelelo. Kwinqanaba elisezantsi, ikhonkco le-polymer ye-HPMC isasazeke ngokubanzi kwi-solvent, ngoko ke i-viscosity iphantsi. Nangona kunjalo, kwindawo ephezulu, ikhonkco lepolymer lihlala lisebenzisana, likhokelela kwi-viscosity ephezulu. Ke ngoko, i-viscosity ye-HPMC ihambelana nokuxinana kwepolymer. Ukugxininiswa kwakhona kuchaphazela ukuziphatha kwe-gelization ye-HPMC. I-HPMC ephezulu yoxinaniso inokwenza ijeli, ebaluleke kakhulu kwishishini lamayeza kunye nokutya.

ubushushu

Ubushushu yenye into ephambili echaphazela i-viscosity ye-hydroxylopenyl cellulose. viscosity HPMC kaThixo kuncipha ngokunyuka kwamaqondo obushushu. Ikhonkco le-polymer ye-HPMC iba nokuhamba ngakumbi kwiqondo lobushushu eliphezulu, okukhokelela kwi-viscosity ephantsi. Xa kuthelekiswa nezisombululo zoxinzelelo oluphezulu, ifuthe lobushushu kwi-HPMC viscosity libonakala ngakumbi kwisisombululo esisezantsi. Ukunyuka kobushushu kuya kuchaphazela ukunyibilika kwe-HPMC. Kwiqondo lokushisa eliphezulu, ukunyibilika kwe-HPMC kuncipha, okukhokelela ekunciphiseni kwe-viscosity okubangelwa ukuhla kwe-chain entanglement.

pH

I-pH yesisombululo se-HPMC yenye into ebalulekileyo echaphazela i-viscosity yayo. I-HPMC yipolima eneasidi ebuthathaka, ene-PKA emalunga ne-3.5. Ngoko ke, i-viscosity yesisombululo se-HPMC inomdla kwi-pH yesisombululo. Ngaphantsi kwexabiso le-pH liphezulu kune-PKA, iqela letyuwa ye-carboxylic acid yepolymer laliphantsi kwe-protonization, eyabangela ukuba i-solubility ye-HPMC inyuke, kwaye i-viscosity yancitshiswa ngenxa yokuncipha kwe-hydrogen bond of interconsiscence molecular. Ngaphantsi kwexabiso le-pH elingaphantsi kwe-PKA, iqela le-carboxylic acid ye-polymer yayinzima, eyabangela ukunyibilika okuphantsi kunye ne-viscosity ephezulu ebangelwa ukunyuka kwe-hydrogen bond. Ngoko ke, ixabiso le-pH elingcono kakhulu lesisombululo se-HPMC lixhomekeke kwisicelo esilindelekileyo.

Ubunzima bemolekyuli

HPMC kaThixo ubunzima molekyuli yenye into ebalulekileyo echaphazela viscosity yayo. I-HPMC yipolymer. Njengoko ubunzima be-molecular of polymer bunyuka, i-viscosity yesisombululo se-HPMC iya kwanda. Oku kungenxa yokuba ikhonkco eliphezulu lobunzima bemolekyuli yeHPMC ibambene ngakumbi, okukhokelela ekwandeni kwe-viscosity. Ubunzima bemolekyuli yepolymer ikwachaphazela i-HPMC gelization. Ipholima ye-HPMC isenokwenzeka ukuba yenze iijeli kuneepholima ezinobunzima bemolekyuli ephantsi.

Ityuwa

Ukongeza ityuwa kwisisombululo se-HPMC sinokuchaphazela kakhulu i-viscosity yayo. Ityuwa ichaphazela amandla e-ion yesisombululo se-HPMC, esitshintsha ukusebenzisana kweepolymers. Ngokuqhelekileyo, ukongeza ityuwa kwisisombululo se-HPMC kuya kubangela ukuba i-viscosity iyancipha. Oku kungenxa yokuba amandla e-ion yesisombululo ayancipha phakathi kwamandla emolekyuli phakathi kwekhonkco le-polymer ye-HPMC, ngaloo ndlela kuncitshiswa ukuncitshiswa kwe-chain entanglement, ngoko ke i-viscosity iyancitshiswa. Umphumo wetyuwa kwi-viscosity yesisombululo se-HPMC kuxhomekeke kuhlobo kunye noxinzelelo lwetyuwa.

ukuququmbela

I-viscosity ye-hydroxydal cibolin yiparameter ephambili echaphazela ukusetyenziswa kwayo kumashishini ahlukeneyo. Izinto ezichaphazela i-viscosity ye-HPMC ziquka ukugxila, ubushushu, i-pH, ubunzima be-molecular kunye netyuwa. Ukuqonda ezi zinto kwi-viscosity ye-HPMC kubalulekile ukukhulisa ukusetyenziswa kwayo kwizicelo ezahlukeneyo. Isisombululo se-HPMC sinokulungiswa ngokufanelekileyo ukufezekisa i-viscosity efunekayo ecacileyo.