Ukuqaliswa kwezicelo ze-HPMC kwi-Pharmaceutics

I-Hydroxypropyl methylcellulose (i-HPMC) yi-derivative ye-cellulose eye yafumana ukusetyenziswa okubanzi kwishishini lamachiza ngenxa yeempawu zayo ezizodwa, kubandakanywa ukunyibilika kwamanzi, ukuhambelana kwe-biocompatibility, kunye nokukwazi ukwenza ifilimu. Ezinye zezicelo eziqhelekileyo ze-HPMC kumachiza ziquka:

Itheyibhile yokwaleka: I-HPMC isetyenziswa njenge-agent eyenza ifilimu kwi-tablet yokwaleka ukuphucula imbonakalo, ukuzinza, kunye nencasa yeepilisi. Inokubonelela ngengubo egudileyo kunye nefanayo ekhusela isithako esisebenzayo kwizinto ezisingqongileyo, ezifana nokufuma kunye nokukhanya, ngelixa likhusela ithebhulethi ukuba ibambelele kwizinto zokupakisha. I-HPMC ikwasetyenziswa njengesibophelelo kuqulunqo lwethebhulethi, ukuphucula ubulukhuni bethebhulethi kunye nokuqhekeka.

Iinkqubo ezilawulwayo ezikhutshwayo: I-HPMC isetyenziswa njengesixhobo se-matrix ekuphuhliseni iinkqubo zokukhutshwa ezilawulwayo, ezifana neepilisi ezizinzileyo kunye neepilisi. Inokwenza i-hydrophilic matrix elawula izinga lokukhutshwa kwechiza, ngokudumba kunye nokunyibilika kancinci kulwelo lwesisu. Iprofayile yokukhutshwa kwechiza inokuguqulwa ngokutshintsha i-HPMC yoxinaniso, ubunzima bemolekyuli, kunye neqondo lokuthatha indawo.

Ukwenziwa kwamehlo: I-HPMC isetyenziswa njengesiphuculi se-viscosity kunye ne-arhente yokuxhoma kwi-ophthalmic formulations, njengamathontsi eliso kunye ne-ointments. Inokuphucula i-bioavailability kunye nexesha lokugcinwa kwezinto ezisebenzayo kwiso, ngokunyusa i-viscosity kunye neempawu ze-mucoadhesive zokuqulunqwa.

Imixube emixholweni: I-HPMC isetyenziswa njenge-arhente etyebisayo kunye ne-emulsifier kwimixube yezihloko, ezifana neekhrimu, iijeli, kunye nezinto zokuthambisa. Inokubonelela ngokucokisekileyo kunye nokuzinzileyo ekuqulunqweni, ngelixa iphinda iphucule ukungena kwesikhumba kunye nokukhululwa kweziyobisi. I-HPMC ikwasetyenziswa njenge-arhente ye-bioadhesive kwi-patches ye-transdermal, ukunyusa ukunamathela kwesikhumba kunye nokungena kweziyobisi.

Ngokubanzi, i-HPMC i-polymer eguquguqukayo enokubonelela ngoluhlu lweenzuzo ekuphuhliseni ukwakhiwa kwamachiza, kubandakanywa ukukhutshwa kweyeza eliphuculweyo, i-bioavailability, ukuzinza, kunye nokuthotyelwa kwesigulane. Ukhuseleko lwayo, i-biocompatibility, kunye nokusebenziseka ngokulula kwenza kube lukhetho oludumileyo kubenzi bamayeza kwihlabathi liphela.