hydroxypropyl methylcelculose (hpmc)Ngaba i-selsulose yafolwiuse isuswe ngokubanzi isetyenziswa ngamalungiselelo amachiza asemachiza, ngakumbi amalungiselelo aqinileyo aqinileyo, amalungiselelo omlomo angamanzi kunye namalungiselelo e-ophthalmic. Njengombono wamayeza obalulekileyo, iKimbocell®HPMC inemisebenzi emininzi, efana ne-Adheetive, iArhente yokuLawula i-Gin, i-HPMC, njl. Njl.
Iipropathi ze-HPMC
I-HPMC yi-foil-inyibilikisi enyibilikisi okanye inyibilikisi-i-foil inyibilikisi efunyenwe ngokutshintsha inxenye yamaqela e-hydroxyl kwimolekyuli ye-sellum kunye ne-methyl kunye namaqela e-hydroxypropyl. Inokuqina kakuhle kunye nokujonga emanzini, kwaye isisombululo sibonakala okanye sine-turbid kancinci. I-HPMC inozinzo oluhle kwizinto ezinje ngemeko yokusingqongileyo kunye noguquko lobushushu, ngoko ke isetyenziswa ngokubanzi kulungiselelo lwamachiza.
I-HPMC ine bhayoloji elungileyo kwi-gestrointenal phecanal phecanal, i-biomatining elungileyo kunye netyhefu, kwaye amalungiselelo awo akukho lula ukuba abangele ukusebenzisa kumalungiselelo e-chirmagec.
Ukusetyenziswa kwe-HPMC kumalungiselelo amachiza
Isicelo kumalungiselelo okukhutshwa
I-HPMC isetyenziswa ngokubanzi kumalungiselelo okukhutshwa, ngakumbi kumalungiselelo aqinileyo aqinileyo. I-HPMC inokulawula inqanaba lokukhutshwa kweziyobisi ngokusebenzisa i-gel yenethiwekhi ye-IT I-IT. Kwichiza elinyibilikayo lamanzi, i-HPMC njenge-Arhente yokuGqibela-ngokukhululekileyo inokulibazisa inani lokukhupha iziyobisi, ngaloo ndlela isandisa ixesha lokusebenza kweziyobisi, ukunciphisa inani lamaxesha odoli, kunye nokuphucula ukuthotyelwa koguli.
Umgaqo wokwenza isicelo se-HPMC kwiNkqubo yokuKhulula iZilungisile isekwe kukhulula i-solity kunye neepropathi zokudumba emanzini. Xa iitafile okanye iicaphule zingena kwiphecana le-gestrointenal, i-HPMC iza kudibana namanzi, ifumana amanzi kunye nokubila ukwenza i-gel mail, enokukhupha iMichiza kunye nokukhutshwa kwamachiza. Ireyithi yokukhutshwa kweziyobisi inokuhlengahlengiswa ngohlobo lwe-HPMC (njengamaqela ahlukeneyo okufaka endaweni ye-HydroxyPlPlapy kunye ne-Methyl amaqela) kunye noxinzelelo lwayo.
Ii-Binders kunye nee-Agents zefilimu
Ngamalungiselelo aqinileyo anjengeetafile, iicaphule, kunye neegram, i-HPMC njengomntu obhinqileyo unokuphucula ubulukhuni kunye nokugcina amalungiselelo. Isiphumo se-HPMC kwi-HPMC kwilungiselelo alinakwenza kuphela amasuntswana amachiza okanye i-polders bond omnye komnye, kodwa ukwandisa uzinzo lwamalungiselelo kunye nokubizwa kwayo emzimbeni.
Njengearhente yefilimu yokwakha ifilimu, i-HPMC inokwenza ifilimu efanayo kwaye ihlala isetyenziselwa ukukhathaza kweziyobisi. Ngexesha lenkqubo yokuhlambela kwamalungiselelo, i-kimbacell®HPMC ayinakukhusela ichiza kwimpembelelo yendawo yangaphandle, kodwa ikwalawula inqanaba lokukhupha ichiza. Umzekelo, kulungiselelo lweetafile ezinamaphepha ahlanganisiweyo, i-HPMC njengezinto zokuhamba kancinci zinokuthintela ichiza ukuba likhutshwe esiswini kwaye liqinisekise ukuba ichiza likhutshwa emathunjini.
Iarhente yeGeling kunye ne-thickener
I-HPMC isetyenziswe ngokubanzi kwi-Ophthalmimic kunye nezinye izicwangciso zolwelo njengearhente yeqela. Kwiziyobisi ze-Ophthalmic, i-HPMC inokusetyenziswa njengenxalenye yenkgengi kwiinyembezi zokugcina izinto zokuphucula ixesha lechiza kunye nefuthe lokucoca iliso, kwaye linciphise iqondo lokuphuma kwamanzi. Ukongeza, i-HPMC ikwanazo iipropathi ezinkulu eziqatha, ezinokunyusa i-viscofity yokulungiselela uxinzelelo oluthile, kwaye ilungele amalungiselelo ahlukeneyo olwenzi.
Kwimilo engama-oral Alling, i-HPMC njenge-thickener inokuphucula uzinzo lwamalungiselelo, thintela ukulinganisa kunye nokuxhuzula amasuntswana, kwaye iphucule incasa kunye nembonakalo.
I-Stabilizer yamalungisa e-oral
I-HPMC inokwenza isisombululo esizinzileyo se-colloidal kumalungiselelo olwelo, ngaloo ndlela kuphucule uzinzo lwamalungiselelo. Ingaphucula ukubenzela amandla kunye nokufana kwamachiza kumalungiselelo olwelo kunye nokukhusela i-rytalization yeziyobisi kunye nokutsha. Xa ulungiselela iziyobisi ezinqabileyo kwaye ezinokongezayo, ukongezwa kwe-HPMC kunokwandisa ubomi beshelf yeshesi.
Njenge-emulsifier
I-HPMC inokusetyenziswa njenge-enulsifier ukuzinzisa i-emulsion kwaye isasaze ichiza xa ilungiselela iziyobisi zohlobo lwe-emulsion. Ngokulawula ubunzima bemolekyuli kunye nokugxininiswa kwe-HPMC, uzinzo kunye neepropathi ze-emulsion zinokulungiswa ukuze zilungele iindlela ezahlukeneyo zamayeza.
IZIBONELELO ZEENKONZO ZE-HPMC
I-biomial yokhuseleko oluphezulu kunye nokhuseleko: i-HPMC, njengetyhefu yendalo, inetyhefu elungileyo, ayinabungozi kwaye ilunge kakhulu ekusetyenzisweni kwamalungiselelo eziyobisi.
Umsebenzi wokuLawulwa: I-HPMC inokulawula inqanaba lokukhutshwa kweziyobisi ngokusebenzisa iipropathi zalo zokulungisa, ikwandisa ukusebenza ngempumelelo iziyobisi, ukunciphisa irejista yolawulo, kunye nokuphucula ukuthotyelwa kooguli.
Uluhlu olubanzi lwezicelo:I-HPMCinokusetyenziswa kwiifom ezahlukeneyo zethamo ezifana neetafile, iicapbules, amaqhina, kunye namalungiselelo olwelo, ukuhlangabezana neemfuno zamalungiselelo ohlukeneyo echiki.
I-Hydroxypropyl Methylcelceltulose inexabiso elibalulekileyo lesicelo kumalungiselelo eziyobisi. Ayinakusetyenziswa kuphela njengearhente yokukhutshelwa okuzinzileyo, i-onheves, kunye nearhente yokwenza ifilimu, kodwa njenge-thi choner kunye nokuzinzisa kumalungiselelo olwelo. Iipropathi zayo ezilungileyo zomzimba kunye nekhemikhali zenza ukuba ibe ne-insuline ethandekayo kumzi-mveliso wamayeza, ngakumbi ukubonisa amandla amakhulu ekuphuculeni uzinzo lwamayeza kunye nokulawula izinga lokukhupha iziyobisi. Ngokuqhubela phambili phambili kwitekhnoloji yamayeza, ithemba lesicelo le-kimbacell®HPMC liya kuqhubeka nokwandisa, ukubonelela ngenkxaso kumalungiselelo akhuselekileyo kunye nophuhliso lwamachiza amaninzi.
IXESHA LOKUQALA: UJAN-27-2025