Ukusetyenziswa kweHPMC kumalungiselelo

1 njengezinto zokugquma ifilimu kunye nezinto zokwenza ifilimu

Ukusebenzisa i-hypromellose (HPMC) njengesixhobo sethebhulethi efakwe ifilimu, xa kuthelekiswa neetafile ezigqunywe ngokwesiko ezifana neetafile ezigqunywe ngeswekile, iitafile ezigqunywe ngeswekile azinanzuzo zicacileyo zokufihla incasa yeyeza kunye nenkangeleko, kodwa ukuqina kunye nokuqina, ukufunxa ukufuma, ukuqhekeka, ukuzuza ubunzima bokugquma kunye nezinye izikhombisi zekhwalithi zingcono. Ibanga eliphantsi le-viscosity yale mveliso lisetyenziswa njengento yokugubungela ifilimu ene-soluble yamanzi kwiipilisi kunye neepilisi, kwaye ibakala eliphezulu le-viscosity lisetyenziswa njengento yokugubungela ifilimu kwiinkqubo ze-solvent ze-organic. Ukugxininiswa ngokuqhelekileyo yi-2.0% ukuya kwi-20%.

2 njengesibophelelo kunye ne-disintegrant

Ibakala eliphantsi le-viscosity yale mveliso lingasetyenziselwa njenge-binder kunye ne-disintegrant yamacwecwe, iipilisi, kunye ne-granules, kwaye i-high-viscosity grade ingasetyenziswa kuphela njenge-binder. Idosi iyahluka ngeemodeli ezahlukeneyo kunye neemfuno. Ngokuqhelekileyo, idosi ye-binder kwiipilisi ezomileyo ze-granulation yi-5%, kunye ne-dosage ye-binder kwiipilisi ezimanzi ze-granulation yi-2%.

3 njenge-arhente exhomayo

I-agent yokumisa i-viscous gel substance ene-hydrophilicity, enokunciphisa isantya se-sedimentation yamasuntswana xa isetyenziswe kwi-arhente yokumisa, kwaye inokudityaniswa kumphezulu weengqungquthela ukukhusela amaqhekeza ukuba adibanise kunye nokuncipha kwibhola. . Iiarhente ezixhomayo zidlala indima ebalulekileyo ekwenzeni ukunqunyanyiswa. I-HPMC luhlobo olugqwesileyo lweearhente zokuxhoma, kunye nesisombululo sayo esinyibilikisiweyo se-colloidal sinokunciphisa ukuxinana kojongano olululwelo oluqinileyo kunye namandla asimahla kumasuntswana amancinane aqinileyo, ngaloo ndlela aphucula uzinzo lwenkqubo yokusasazwa kwe-heterogeneous. Ibakala eliphezulu le-viscosity yale mveliso lisetyenziselwa ukulungiswa kolwelo olumisiweyo olulungiselelwe njenge-arhente yokumisa. Inesiphumo esihle sokuxhoma, kulula ukuphinda isasazeke, ayibambeleli eludongeni, kwaye inamasuntswana athambileyo. Idosi eqhelekileyo yi-0.5% ukuya kwi-1.5%.

4 njenge-blocker, i-arhente yokukhululwa eqhubekayo kunye ne-ejenti ebangela i-pore

Ibanga eliphezulu le-viscosity yale mveliso lisetyenziselwa ukulungiselela i-hydrophilic gel matrix yokukhululwa okuqhubekayo, i-blockers kunye ne-controlled-release agents kwi-mixed material matrix ukukhululwa okuqhubekayo kweepilisi, kwaye inefuthe lokulibazisa ukukhutshwa kweziyobisi. Ukugxininiswa kokusetyenziswa kwayo yi-10% ~ 80% (W / W). Amanqanaba e-low-viscosity asetyenziswa njenge-pore-forming agents ukwenzela ukukhululwa okuqhubekayo okanye ukukhutshwa okulawulwayo kwamalungiselelo. Idosi yokuqala efunekayo kwisiphumo sonyango solu hlobo lwethebhulethi inokufezekiswa ngokukhawuleza, kwaye emva koko ikhuphe isiphumo esizinzileyo okanye esilawulwayo sokukhululwa, kwaye ukugxininiswa kweziyobisi okusebenzayo kugcinwa emzimbeni. Xa i-hypromellose idibana namanzi, igalela amanzi ukuze yenze umaleko wejeli. Indlela yokukhutshwa kweziyobisi kwithebhulethi ye-matrix ikakhulu ibandakanya ukusasazwa komgangatho wejeli kunye nokukhukuliseka komgangatho wejeli.

5 njenge-thickener kunye neglue ekhuselayo ye-colloidal

Xa le mveliso isetyenziswa njenge-thickener, i-concentration esetyenziswa ngokuqhelekileyo yi-0.45% ~ 1.0%. Le mveliso inokunyusa ukuzinza kweglue ye-hydrophobic, yenza i-colloid ekhuselayo, ithintele amaqhekeza kwi-agglomerating kunye ne-agglomerating, ngaloo ndlela inqanda ukubunjwa kwentlenga, kunye nokugxininiswa kwayo ngokuqhelekileyo yi-0.5% ~ 1.5%.

6 njengempahla ye-capsule

Ngokuqhelekileyo i-capsule shell capsule impahla ye-capsule isekelwe kwi-gelatin. Inkqubo yokuveliswa kwegobolondo ye-gelatin capsule ilula, kodwa kukho ezinye iingxaki kunye neziganeko ezifana nokukhuselwa kakubi kumanzi kunye ne-oxygen iziyobisi ezibuthathaka, izinga eliphantsi lokuchithwa kweziyobisi, kunye nokulibaziseka ukuchithwa kwegobolondo le-capsule ngexesha lokugcinwa. Ngoko ke, i-hypromellose, njenge-substitute ye-gelatin capsules, isetyenziselwa ukulungiswa kwee-capsules, eziphucula ukubunjwa kunye nokusetyenziswa kwefuthe le-capsules, kwaye iye yakhuthazwa ngokubanzi ekhaya nakwamanye amazwe.

7 njenge-bioadhesive

Itekhnoloji ye-Bioadhesion, ukusetyenziswa kwe-excipients kunye ne-polymers ye-bioadhesive, ngokunamathela kwi-mucosa ye-biological, iphakamisa ukuqhubeka kunye nokuqina koqhagamshelwano phakathi kokulungiswa kunye ne-mucosa, ukuze ichiza likhutshwe ngokukhawuleza kwaye lifunxwe yi-mucosa ukufezekisa iinjongo zonyango. Okwangoku isetyenziswa ngokubanzi Isetyenziselwa ukunyanga izifo ze-nasal cavity, i-mucosa yomlomo kunye nezinye iindawo. Itekhnoloji ye-bioadhesion ye-gastrointestinal yinkqubo entsha yokuhanjiswa kwechiza ephuhliswe kwiminyaka yakutshanje. Ayinakwandisa nje ixesha lokuhlala lamalungiselelo amayeza kwindlela yesisu, kodwa ikwaphucula ukusebenza koqhagamshelwano phakathi kwechiza kunye nenwebu yeseli kwindawo yokufunxa, ukuguqula ulwelo lwenwebu yeseli, Ukuphucula ukungena kwechiza emathunjini. iiseli epithelial, ngaloo ndlela kuphuculwe bioavailability ichiza.

8 njengejeli yezihloko

Njengokulungiselela ukunamathela kwesikhumba, i-gel inoluhlu lweenzuzo ezifana nokhuseleko, ubuhle, ukucocwa lula, ixabiso eliphantsi, inkqubo yokulungiselela elula, kunye nokuhambelana kakuhle neziyobisi. ulwalathiso.

9 njenge-sedimentation inhibitor kwi-emulsification system