Ukusetyenziswa kwe-Ethylcellulose Coating kwi-Hydrophilic Matrices

I-Ethylcellulose (EC) yipolymer esetyenziswa ngokuqhelekileyo kwishishini loxubo-mayeza ukugquma imixube yamachiza. Yipolymer ye-hydrophobic enokubonelela ngomqobo wokukhusela ichiza kumswakama, ukukhanya, kunye nezinye izinto zokusingqongileyo. Iingubo ze-EC zinokuguqula ukukhutshwa kwechiza ekuqulunqweni, njengokubonelela ngeprofayili yokukhululwa ezinzileyo.

I-Hydrophilic matrices luhlobo lokuqulunqwa kweziyobisi eziqulethe i-polymers e-soluble yamanzi okanye ukudumba kwamanzi, njenge-hydroxypropyl methylcellulose (HPMC). Ezi matrices zingasetyenziselwa ukubonelela ngokukhutshwa okulawulwayo kwechiza, kodwa zinokuba sesichengeni sokufunxwa kwamanzi kunye nokukhutshwa kwechiza okulandelayo. Ukoyisa lo mda, iingubo ze-EC zingasetyenziswa kumphezulu we-hydrophilic matrix ukwenza umaleko okhuselayo.

Ukusetyenziswa kweengubo ze-EC kwiimatriki ze-hydrophilic kunokubonelela ngeenzuzo ezininzi. Okokuqala, i-coating ye-EC inokusebenza njengesithintelo sokufuma ukukhusela i-matrix ye-hydrophilic ekuthathweni kwamanzi kunye nokukhululwa kweyeza okulandelayo. Okwesibini, i-coating ye-EC inokuguqula ukukhululwa kweyeza kwi-matrix ye-hydrophilic, njengokubonelela ngeprofayili yokukhululwa okuqhubekayo. Ekugqibeleni, i-coating ye-EC inokuphucula ukuzinza komzimba wokuqulunqwa, njengokuthintela i-agglomeration okanye ukunamathela kwiinqununu.

Ukusetyenziswa kweengubo ze-EC kwiimatriki ze-hydrophilic kunokufezekiswa kusetyenziswa iindlela ezahlukeneyo zokugquma, ezifana nokugquma kokutshiza, ukugquma kwebhedi, okanye ukugquma ngepani. Ukukhethwa kobuchule bokugquma buxhomekeke kwizinto ezifana neempawu zokubumba, ubukhulu obufunwayo bokugquma, kunye nomlinganiselo wemveliso.

Isishwankathelo, ukusetyenziswa kweengubo ze-EC kwi-matrices ye-hydrophilic sisicwangciso esiqhelekileyo kwishishini lamachiza ukuguqula iprofayili yokukhululwa kunye nokuphucula ukuzinza kweendlela zokwenziwa kweziyobisi.