Yazisa
IHydroxypropyl methylcellulose, eyaziwa ngokuba yi-HPMC, yipolymer enyibilikayo emanzini esetyenziswa kakhulu kumayeza, kwizinto zokuthambisa, ukutya nakwamanye amashishini. I-HPMC ingasetyenziswa njenge-thickener, binder, emulsifier kunye nezinzisi.
1. Khetha ibakala elifanelekileyo le-HPMC
I-solubility ye-HPMC ixhomekeke kubunzima bayo beemolekyuli, iqondo lokutshintshela, kunye nobungakanani besuntswana. Ukukhetha ibakala elichanekileyo le-HPMC kubalulekile ukuqinisekisa ukunyibilika kwayo ngokufanelekileyo kwisicelo esithile.
Umzekelo, ubunzima bemolekyuli ephantsi HPMC ine-solubility engcono emanzini kunye nezinyibilikisi ze-organic kune-high molecular weight HPMC. Nangona kunjalo, ubunzima obuphezulu bemolekyuli ye-HPMC ineempawu ezingcono zokwenza ifilimu, nto leyo eyenza ukuba ilungele ukugquma ithebhulethi.
Ngokunjalo, i-HPMC eneqondo eliphezulu lokutshintshwa inyibilika ngakumbi emanzini kune-HPMC eneqondo eliphantsi lokutshintshwa. I-HPMC eneqondo eliphantsi lokutshintshwa isoloko isetyenziswa kwimixube yokukhutshwa okuzinzileyo kuba yenza imatrix ezinzileyo nexineneyo.
Ubungakanani besuntswana le-HPMC nalo lichaphazela ukunyibilika kwayo. Amasuntswana acolekileyo e-HPMC anyibilika ngokukhawuleza kunamasuntswana arhabaxa. Ngoko ke, kubalulekile ukukhetha ubungakanani obuchanekileyo be-HPMC kwisicelo esithile.
2. Sebenzisa isinyibilikisi esichanekileyo
Ukunyibilika kwe-HPMC kuxhomekeke kuhlobo lwesinyibilikisi. I-HPMC iyanyibilika emanzini kunye nezinye izinyibilikisi eziphilayo, ezifana ne-ethanol, i-methanol, kunye ne-isopropyl alcohol. Nangona kunjalo, ukunyibilika kwe-HPMC kwizinyibilikisi zendalo kuxhomekeke kwi-polarity yayo.
Amanzi sesona sinyibilikisi sisetyenziswa kakhulu kwi-HPMC kuba ayinatyhefu, ayinaxabiso, kwaye sifumaneka lula. Ukunyibilika kwe-HPMC emanzini kunokwandiswa ngokugalela ityuwa okanye ukulungisa i-pH.
Ishishini lamachiza ngokuqhelekileyo lisebenzisa i-solvents eziphilayo ezifana ne-ethanol, i-methanol, kunye ne-isopropyl alcohol ukutshabalalisa i-HPMC ekuqulunqweni okufana neepilisi, iipilisi, kunye nezisombululo zomlomo. Nangona kunjalo, kusenokubakho izinto ezingeloncedo ekusebenziseni izinyibilikisi eziphilayo, ezinje ngetyhefu, ukutsha, kunye nokukhathazeka kokusingqongileyo.
3. Iindlela ezifanelekileyo zokusasaza
Indlela yokusasaza i-HPMC kwi-solvent ikwachaphazela ukunyibilika kwayo. Eyona ndlela ixhaphakileyo yokusasaza i-HPMC yigranulation emanzi, apho i-HPMC ixutywe nezinye izinto ezincedisayo kunye ne-solvent yongezwa ukwenza intlama. Intlama iye yomiswa ize ihluzwe ukuze kufunyanwe iigranules.
Nangona kunjalo, iindlela ezingafanelekanga ze-granulation ezimanzi zinokubangela ukunyibilika okulambathayo kunye nokunyibilika kwe-HPMC kwimveliso yokugqibela. Ngoko ke, kubalulekile ukusebenzisa iindlela ezifanelekileyo zegranulation ezimanzi (umzekelo, ukuxuba ngokufanelekileyo, ukomisa, kunye nokusefa) ukufumana iigranules zobukhulu obufanelekileyo kunye nokuxinana.
Enye indlela yokusasazwa kwe-HPMC yindlela eyomileyo ye-granulation, apho i-HPMC ixutywe kunye nezinye izinto ezincedisayo kwaye zixinaniswe kwiipilisi. Amacwecwe ke ayacolwa aze ahluzwe ukuze kufunyanwe iigranules. Xa usebenzisa iziyobisi ezibuthathaka, i-granulation eyomileyo ikhethwa kwaye i-solvents akufanele isetyenziswe.
4. Iimeko zokugcina
Iimeko zokugcina ze-HPMC nazo zichaphazela ukunyibilika kwayo. I-HPMC kufuneka igcinwe kwindawo eyomileyo, epholileyo kunye nemnyama ukuthintela ukufuma kunye nokukhanya kwelanga. Ukufuma kubangela ukuba i-HPMC idumbe, ngaloo ndlela ichaphazela ukunyibilika kwayo.
Ukuququmbela
Ukukhetha ibakala elifanelekileyo le-HPMC, usebenzisa isinyibilikisi esifanelekileyo, iteknoloji efanelekileyo yokusasazwa, kunye neemeko ezifanelekileyo zokugcina izinto ezibalulekileyo ezichaphazela ukunyibilika kwe-HPMC. Ngokuqwalasela ezi zinto, ukunyibilika kwe-HPMC kunokuphuculwa ukufezekisa umgangatho ofunekayo wemveliso yokugqibela.
Ixesha lokuposa: Sep-13-2023