Chii chinonzi hydroxypropyl methyl cellulose?

Hydroxypropyl methylcellulose(HPMC) i polymer yekugadzira iyo inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, kusanganisira mishonga, chikafu, zvekuzora, uye kuvaka. Imhando ye cellulose ether inogadzirwa nekemikari kugadziriswa kwechisikigo cellulose, iyo yakaoma carbohydrate inowanikwa mumiti. HPMC inonyungudika mumvura, isinganhuhwi, uye isinganakidze komboni ine zvinhu zvakawanda zvinoita kuti ishande mumhando dzakasiyana dzekushandisa.

HPMC inoumbwa nezvikamu zviviri zvakakosha: methyl cellulose (MC) uye hydroxypropyl cellulose (HPC). MC is a cellulose derivative inowanikwa nekuita selulosi ine sodium hydroxide uye methyl chloride. Iyi nzira inoguma nekuwedzerwa kwemapoka emethyl kumusana we cellulose, iyo inovandudza kunyungudika kwayo mumvura. HPC, kune rumwe rutivi, inobva kune cellulose inowanikwa nekuita nayo nepropylene oxide. Iyi nzira inoguma nekuwedzera kwemapoka e-hydroxypropyl kumusana we cellulose, iyo inowedzera kuvandudza kunyungudika kwayo mumvura.

Iko kusanganiswa kwezvikamu zviviri izvi muHPMC kunopa iyo yakasarudzika zvivakwa senge yakawedzera viscosity, yakagadziridzwa kuchengetedza kwemvura, uye yakawedzera kunamatira. Iyo ine zvakare kugona kugadzira gels kana yakasanganiswa nemvura, izvo zvinoita kuti ibatsire seyakakora mumiriri mumaindasitiri mazhinji.

Pharmaceutical Applications yeHPMC

Imwe yekushandiswa kwekutanga kweHPMC iri muindasitiri yemishonga, kwainoshandiswa sechinhu chinobatsira mukugadzirwa kwezvinhu zvakasiyana siyana zvemishonga. Mushonga (excipient) chinhu chinowedzerwa kuchigadzirwa chemushonga kuti chifambise kugadzira, kutonga, kana kunyura. HPMC inowanzoshandiswa sebhainda, disintegrant, uye thickening agent mukugadzirwa kwemapiritsi, capsules, uye mamwe mafomu akasimba emushonga.

Mukugadzira mahwendefa, HPMC inoshandiswa sebhainda kubata chinhu chinoshanda uye zvimwe zvinoyamura pamwechete. Inoitawo se disintegrant, iyo inobatsira piritsi kuti iparare kana yasangana nemvura kana zvimwe zvinwiwa zvemuviri. HPMC inonyanya kubatsira senge disintegrant mumapiritsi anoitirwa kumedzwa akazara, sezvo ichibvumira piritsi kuti riparare nekukasira uye kuburitsa iyo inoshanda.

HPMC inoshandiswawo seyakakora mumiriri mune yemvura dosage mafomu senge kumiswa, emulsions, uye gels. Iyo inovandudza viscosity uye kuumbwa kwezviumbwa izvi, izvo zvinogona kuvandudza kugadzikana kwavo uye nyore kwekutonga. Mukuwedzera, HPMC inogona kushandiswa seyakagadziriswa-yakasunungurwa mumiririri, iyo inobvumira kuti mushonga usunungurwe zvishoma nezvishoma kwenguva yakareba.

Zvekudya Zvishandiso zveHPMC

Muindasitiri yechikafu, HPMC inoshandiswa seyakakora mumiriri, emulsifier, uye stabilizer. Inowanzoshandiswa mumasosi, mapfekero, uye zvimwe zvigadzirwa zvekudya zvemvura kuti zvivandudze magadzirirwo uye kugadzikana. HPMC inogona zvakare kushandiswa sechinhu chinotsiva mafuta mune zvigadzirwa zvakaderera-mafuta, sezvo ichikwanisa kutevedzera magadzirirwo uye muromo wemafuta pasina kuwedzera mamwe macalorie.

Cosmetic Applications yeHPMC

HPMC inoshandiswawo muindastiri yezvizorwa sechinhu chinokora, emulsifier, uye binder. Inowanzoshandiswa mumafuta ekuzora, makirimu, uye zvimwe zvigadzirwa zvekuzora kuti zvivandudze magadzirirwo azvo uye kugadzikana. HPMC inogona zvakare kushandiswa semugadziri wekugadzira firimu, anogona kuvandudza kunamatira uye kuramba kwemvura kwezvigadzirwa zvekuzora.

Kuvaka Zvikumbiro zveHPMC

Muindasitiri yekuvaka, HPMC inoshandiswa seyakakora mumiriri uye mumiriri wekuchengetedza mvura mukugadzira simende nedhaka. Inogona kuvandudza kushanda uye kuenderana kwezviumbwa izvi, izvo zvinogona kuvandudza kushanda kwavo uye kusimba. HPMC inogona zvakare kushandiswa sechidziviriro colloid, iyo inogona kudzivirira kuunganidzwa kwemasimende zvimedu uye kunatsiridza dispersibility yavo.

Kuchengetedzwa uye Regulatory

HPMC inowanzoonekwa yakachengeteka kushandiswa mukudya, mishonga, uye zvigadzirwa zvekuzora. Yakave yakadzidzwa zvakanyanya nekuda kwekuchengetedza kwayo uye chepfu, uye inorondedzerwa sechinhu chisiri chepfu, chisiri checarcinogenic, uye chisiri mutagenic.

MuUnited States, HPMC inodzorwa neFood and Drug Administration (FDA) sechikafu chekuwedzera, uye neUnited States Pharmacopeia (USP) semubatsiri wemishonga. Inodzorwawo nemamwe masangano anodzora munyika dzakasiyana pasi rose.

Zvisinei nekuchengeteka kwayo, HPMC inogona kukonzera zviratidzo zvemudumbu zvakapfava zvakadai sekuputika, flatulence, uye manyoka mune vamwe vanhu. Zviratidzo izvi zvinowanzo nyoro uye kuzvimisa, uye zvinogona kudzivirirwa nekushandisa HPMC zvine mwero.

Mukupedzisa, hydroxypropyl methylcellulose (HPMC) inoshandiswa zvakasiyana-siyana uye inoshandiswa zvakanyanya kugadzira polymer ine zvakawanda zvekushandisa mumaindasitiri akasiyana. Hunhu hwayo hwakasiyana, hwakadai sekuwedzera viscosity, kuvandudzwa kwekuchengetedza mvura, uye kuwedzeredzwa kunamatira, inoita kuti ishande seyakakora mumiriri, emulsifier, stabilizer, uye binder mumishonga, chikafu, cosmetic, uye zvigadzirwa zvekuvaka. HPMC inowanzoonekwa yakachengeteka uye inodzorwa neakasiyana masangano anodzora pasi rese.