HPMC (Hydroxypropyl Methylcellulose, hydroxypropyl methylcellulose) ipolmer inonyungudika nemvura inoshandiswa zvakanyanya mumaindasitiri emishonga, ezvekudya uye ekuzora. Inonyanya kushandiswa seyakakora, stabilizer, emulsifier, film-forming agent uye control agent. Sunungura zvinhu. Chinhu chayo chikuru ndechekuti inogona kugadzira mhinduro yakajeka mumvura uye ine yakanaka thickening uye adhesion zvivakwa.
pH kukosha kwe HPMC
HPMC pachayo haina yakagadziriswa pH kukosha nekuti haina kwayakarerekera kana zvishoma acidic polymer zvinhu. HPMC is nonionic cellulose derivative, saka haina kunyanya kushandura pH yemhinduro. Kana yanyungudutswa mumvura, iyo pH yemushonga inowanzoenderana nepH yezvinonyungudutsa pachayo pane makemikari zvimiro zveHPMC pachayo.
Kazhinji, iyo pH yeHPMC mhinduro ichasiyana zvichienderana nekunyungudutsa. Kazhinji, iyo pH yeHPMC mhinduro mumvura yakacheneswa inenge iri pakati pe6.0 ne8.0. Hunhu hwemvura kubva kwakasiyana masosi, pamwe neakasiyana viscosity mamakisi eHPMC, anogona kukanganisa zvishoma pH yemhinduro yekupedzisira. Kana zvichidikanwa kushandisa HPMC mhinduro mukati meiyo pH renji, izvi zvinogona kugadziridzwa nekuwedzera mabuffers panguva yekugadzira maitiro.
Mhedzisiro yemuviri nemakemikari zvimiro zveHPMC pane pH
Sezvo HPMC isiri-ionic komboni uye isina mapoka anopatsanurwa mumamorekuru ayo, haikanganisi zvakananga pH yemushonga senge mamwe cationic kana anionic polymers. Maitiro eHPMC mumhinduro anonyanya kukanganiswa nezvinhu zvakaita setembiricha, kutarisisa, uye ionic simba.
Viscosity uye kugadzikana kwemhinduro: Iyo yakakosha parameter yeHPMC ndeye viscosity yayo, huremu hwayo hwemamorekuru hunotaridza maitiro ainoita mumhinduro. Iyo pH yeyakadzika-viscosity HPMC mhinduro inogona kunge iri padyo nepH yemvura pachayo (kazhinji yakatenderedza 7.0), nepo yakakwirira-viscosity HPMC mhinduro inogona kunge iine acidic zvishoma kana alkaline, zvichienderana nekuvapo kwetsvina kana zvimwe zvinowedzera. mune mhinduro. .
Mhedzisiro yekushisa: Iyo viscosity yeHPMC mhinduro inoshanduka nekushisa. Kana tembiricha ichiwedzera, solubility yeHPMC inowedzera uye viscosity inoderera. Shanduko iyi haina kukanganisa zvakananga pH yemhinduro, asi inogona kushandura fluidity uye magadzirirwo emhinduro.
pH kugadzirisa mumamiriro ekushandisa
Mune mamwe maapplication akakosha, akadai seanodzorwa kuburitsa masisitimu emishonga kana chikafu chekuwedzera, panogona kuve nezvinodiwa chaizvo zvepH. Muzviitiko izvi, iyo pH yemhinduro yeHPMC inogona kugadziriswa nekuwedzera asidhi, base, kana buffer mhinduro. Semuenzaniso, citric acid, phosphate buffer, nezvimwewo inogona kushandiswa kugadzirisa pH yemhinduro yeHPMC kuve nechokwadi chekugadzikana uye kushanda kwechigadzirwa chekupedzisira.
Kumashandisirwo eHPMC mukugadzirwa kwemishonga, pH kutonga kwakakosha nekuti kuparara nekuburitswa kwemishonga kunowanzoenderana nepH yenzvimbo. Iyo isiri-ionic hunhu hweHPMC hunoita kuti iratidze kugadzikana kwakanaka kwemakemikari munzvimbo dzine pH hunhu hwakasiyana, zvichiita kuti ive yakakodzera kushandiswa mumuromo mahwendefa, capsules, ophthalmic kugadzirira uye topical pharmaceuticals.
Iyo pH kukosha kweHPMC pachayo haina kukosha yakatarwa. Iyo pH yaro inotsamira zvakanyanya pane iyo solvent uye mhinduro system inoshandiswa. Kazhinji, iyo pH yeHPMC mhinduro mumvura inotangira pa6.0 kusvika 8.0. Mumashandisirwo anoshanda, kana iyo pH yemhinduro yeHPMC ichida kugadziriswa, inogona kugadziriswa nekuwedzera buffer kana acid-base solution.
Nguva yekutumira: Oct-18-2024