Hydroxypropyl methylcellulose (HPMC) chiwedzere chakasiyana-siyana chinoshandiswa zvakanyanya muindasitiri yekuvaka, kunyanya mukuoma musanganiswa wedhaka maumbirwo. Mushonga uyu ndewemhuri ye cellulose ether uye inotorwa kubva ku natural cellulose. HPMC inogadzirwa nekurapa cellulose nepropylene oxide uye methyl chloride, zvichikonzera kugadziridzwa cellulose ine zvinhu zvinowedzerwa. Kuwedzerwa kweHPMC kune yakaoma musanganiswa dhaka maumbirwo inopa akasiyana anodiwa zvivakwa, zvichiita kuti ive chinhu chakakosha mukuvaka kwezvivakwa zvemazuva ano uye zvivakwa.
A.HPMC chimiro uye kuita:
1.Chemical chimiro:
Hydroxypropylmethylcellulose ine chimiro chakaoma chine hydrophilic uye hydrophobic zvikamu. Iwo hydroxypropyl uye methyl mapoka akaunzwa panguva yekubatanidza anopa mamorekuru chaiwo zvivakwa.
2. Kunyungudika kwemvura:
HPMC inonyungudika mumvura, ichiibvumira kunyungudika mumvura inotonhora kuti iite mhinduro yakajeka uye ine viscous. Ichi chivakwa chakakosha mukuoma musanganiswa dhaka maapplication sezvo ichivimbisa kupararira kwakaringana uye kufanana kwekupedzisira musanganiswa.
3. Thermal gelation:
HPMC inoitwa reversible thermogelling process, zvichireva kuti inogona kugadzira gel kana yapiswa uye kudzokera kune mhinduro kana yatonhodzwa. Maitiro aya anobatsira kuvandudza kuchengetwa kwemvura uye kushanda kwemusanganiswa wedhaka.
4. Kugona kugadzira firimu:
HPMC ine firimu-inogadzira zvimiro uye inoumba firimu rekudzivirira pamusoro pevhu revhu. Iyo firimu inosimudzira kunamatira, inoderedza guruva, uye inovandudza kusimba kwese kwedhaka.
B. Basa reHPMC mudhaka rakaoma rakasanganiswa:
1. Kuchengeta mvura:
Rimwe remabasa makuru eHPMC mune yakaoma-musanganiswa madhaka ndeyekusimudzira kuchengetwa kwemvura. Iyo hydrophilic chimiro cheHPMC molecule inoibvumira kutora uye kuchengetedza unyoro, kudzivirira dhaka kubva pakuoma nguva isati yakwana. Izvi zvakakosha pakushanda kwenguva refu uye kurapwa kwakaringana kwedhaka.
2. Kuvandudza kushanda:
Kuwedzera HPMC kune yakaoma musanganiswa dhaka maumbirwo anovandudza kushanda uye kuenderana. Inobatsira kuwana yakatsetseka uye kunyange kushandiswa kwedhaka, zvichiita kuti zvive nyore kubata uye kuisa.
3. Deredza kuderera:
HPMC inobatsira kune sag kuramba kwedhaka, kudzivirira kuti irege kudonha kana kudonha panzvimbo yakatwasuka. Izvi zvinonyanya kukosha pakushanda pakakwirira kana pamadziro.
4. Wedzera kunamatira:
Iyo firimu-kugadzira kugona kweHPMC inobatsira kuvandudza kunamatira pakati pedhaka uye akasiyana substrates. Izvi zvakakosha kuti uwane mabhondi akasimba uye anogara kwenguva refu mumashandisirwo ekuvaka.
5. Mhedzisiro pakuseta nguva:
Nepo HPMC isinganyanyi kukanganisa yekutanga kuseta nguva yedhaka, inogona kupesvedzera iyo yakazara hydration maitiro uye inobatsira mukukura kwesimba renguva refu.
6. Kuchinjika uye kuramba kutsemuka:
Iyo firimu yakaumbwa neHPMC inopa iyo dhaka kuchinjika, ichiita kuti isarambe ichitsemuka. Izvi zvinonyanya kubatsira apo kufamba kwemaitiro kunogona kuitika.
7. Kugadzikana mumamiriro ezvinhu akaoma:
HPMC inopa yakaoma musanganiswa dhaka nekugadzikana pasi peakasiyana emamiriro ekunze, kusanganisira kuratidzwa kune yakaoma mamiriro ekunze. Inovandudza kusimba kwese uye kushanda kwedhaka.
C.Application Notes:
1. Dosage:
Huwandu hwakakodzera hweHPMC hunoenderana nezvinodiwa chaizvo zvemusanganiswa wevhu, kusanganisira zvinodiwa zvivakwa uye mamiriro ekushandisa. Kunyatsofunga uye kuyedzwa kwakakosha pakuona iyo yakanakisa dhodhi.
2. Kugarisana:
HPMC inowirirana nezvimwe zvakasiyana-siyana zvekuwedzera uye zvimisikidzo zvinowanzo shandiswa mukuoma musanganiswa dhaka maumbirwo. Nekudaro, kuyedzwa kwekuenderana kunofanirwa kuitwa kuti ive nechokwadi chekuita kunodiwa uye kudzivirira chero kusangana kwakashata.
3. Hunhu hwemhando:
Hunhu hweHPMC hunoshandiswa mune yakaoma-musanganiswa dhaka inofanirwa kuenderana neindasitiri zviyero uye zvakatemwa. Kuomerera kumazinga emhando inovimbisa kuenderana uye kwakavimbika kwematope kuita.
mukupedzisa:
Hydroxypropyl methylcellulose (HPMC) chinhu chinowedzera chinoshanda chinoita basa rakakosha mukuvandudza mashandiro ematokari akaoma musanganiswa. Kusanganiswa kwayo kwakasiyana-siyana kwezvivakwa, kusanganisira kuchengetedza mvura, kuvandudzwa kwekushanda uye kugona kugadzira firimu, kunoita kuti ive chikamu chakakosha chemaitiro ekuvaka emazuva ano. Sezvo zvinhu zvekuvaka zvichiramba zvichishanduka, kushandiswa kweHPMC mune yakaoma-musanganiswa dhaka maumbirwo anogona kubatsira kukudziridza akasimba, anochinjika uye akasimba zvimiro.
Nguva yekutumira: Zvita-18-2023