Kudzidza nezve rheological maitiro ekonjac glucomannan uye hydroxypropyl methylcellulose compound system

Iyo komputa sisitimu yekonjac glucomannan (KGM) uye hydroxypropyl methylcellulose (HPMC) yakatorwa sechinhu chekutsvagisa, uye yakatsiga-state shear, frequency uye tembiricha yekutsvaira bvunzo yakaitwa pacompound system neinotenderera rheometer. Mhedzisiro yemhinduro yakawanda chikamu uye chiyero chemukomboni pane viscosity uye rheological zvimiro zveKGM/HPMC komputa system yakaongororwa. Zvigumisiro zvinoratidza kuti KGM / HPMC compound system haisi yeNewtonian fluid, uye kuwedzera kwechikamu chemazana uye KGM yemukati yegadziriro inoderedza kunyunguduka kwemushonga wekomboni uye inowedzera viscosity. Mune sol state, KGM neHPMC mamorekuru maketani anoumba yakawedzera compact chimiro kuburikidza nehydrophobic kupindirana. Kuwedzera system mass chikamu uye KGM yemukati inobatsira kuchengetedza kugadzikana kwechimiro. Muchikamu chechikamu chepasi, kuwedzera zvinyorwa zveKGM kunobatsira pakuumbwa kwemajeri ethermotropic; nepo muhupamhi hwechikamu chechikamu system, kuwedzera zvirimo zveHPMC kunobatsira pakuumbwa kweiyo thermotropic gels.

Mazwi akakosha:konjac glucomannan; hydroxypropyl methylcellulose; compound; rheological maitiro

Natural polysaccharides inoshandiswa zvakanyanya muindasitiri yechikafu nekuda kwekukora, emulsifying uye gelling zvivakwa. Konjac glucomannan (KGM) chirimwa chepolysaccharide, chinoumbwa neβ-D-glucose uyeβ-D-mannose muchiyero che 1.6: 1, iyo miviri yakabatanidzwa neβ-1,4 glycosidic bonds, muC- Pane zvishoma zveacetyl panzvimbo yechitanhatu (inenge 1 acetyl yezvikamu gumi nenomwe). Nekudaro, iyo yakakwira viscosity uye kushomeka kwemvura yeKGM aqueous solution inodzikamisa kushandiswa kwayo mukugadzira. Hydroxypropyl methylcellulose (HPMC) ipropylene glycol ether yemethylcellulose, inova isiri-ionic cellulose ether. HPMC inogadzira firimu, inonyungudika mumvura, uye inogona kuvandudzwa. HPMC ine yakaderera viscosity uye gel simba pakudziya kwakadzika, uye kushomeka kwekugadzirisa kuita, asi inogona kuumba inotaridzika yakasimba-yakaita gel pakupisa kwepamusoro, saka maitiro mazhinji ekugadzira anofanirwa kuitwa pakupisa kwakanyanya, zvichikonzera kushandiswa kwesimba kwakanyanya. Mari yekugadzira yakakwira. Zvinyorwa zvinoratidza kuti unsubstituted mannose unit paKGM molecular chain inogona kuumba nzvimbo isina simba-yakabatanidzwa hydrophobic association neboka re hydrophobic paHPMC molecular chain kuburikidza ne hydrophobic interaction. Ichi chimiro chinogona kunonoka uye kudzivirira zvishoma kudziya kweHPMC uye kudzikisa tembiricha yegel yeHPMC. Pamusoro pezvo, tichifunga nezveyakadzika-viscosity zvimiro zveHPMC pane tembiricha yakaderera, zvinofanotaurwa kuti kusanganiswa kwayo neKGM kunogona kuvandudza iyo yakakwirira-viscosity zvimiro zveKGM uye kuvandudza mashandiro ayo ekugadzirisa. Naizvozvo, bepa rino richavaka KGM/HPMC kompani system yekuongorora pesvedzero yemhinduro yakawanda chikamu uye chiyero chemukomboni pane rheological properties yeKGM/HPMC system, uye nekupa theoretical reference yekushandiswa kweKGM/HPMC compound system mu. indasitiri yezvekudya.

1. Zvishandiso uye nzira

1.1 Zvishandiso uye reagents

Hydroxypropyl methylcellulose, KIMA CHEMICAL CO., LTD, chikamu chikuru 2%, viscosity 6 mPa·s; methoxy mass chikamu 28% ~ 30%; hydroxypropyl chikamu chikamu 7.0% ~ 12%.

Konjac glucomannan, Wuhan Johnson Konjac Chikafu Co., Ltd., 1 wt% aqueous solution viscosity≥28 000 mPa·s.

1.2 Zvishandiso uye midziyo

MCR92 rotational rheometer, Anton Paar Co., Ltd., Austria; UPT-II-10T ultrapure mvura muchina, Sichuan Youpu Ultrapure Technology Co., Ltd.; AB-50 electronic analytical balance, Swiss Mette company; LHS-150HC nguva dzose tembiricha tembiricha mvura kugeza, Wuxi Huaze Technology Co., Ltd.; JJ-1 Electric Stirrer, Jintan Medical Instrument Factory, Jiangsu Province.

1.3 Kugadzirira kwemushonga wemusanganiswa

Weresa HPMC neKGM hupfu nehumwe hwumwe chiyero chemusanganiswa (huwandu chiyero: 0:10, 3:7, 5:5, 7:3, 10:0), zvishoma nezvishoma wowedzera mumvura yakasvibiswa mu60.°C mvura yekugeza, uye simbisa kwe 1.5 ~ 2 h kuti iparadzirwe zvakaenzana, uye gadzirira marudzi mashanu ezvigadziriso zvine huremu hwakaomarara zvikamu zve 0.50%, 0.75%, 1.00%, 1.25%, uye 1.50%, zvichiteerana.

1.4 Muedzo we rheological zvimiro zvemusanganiswa mhinduro

Steady-state shear bvunzo: Iyo rheological curve yeKGM/HPMC mukomboni mhinduro yakayerwa uchishandisa CP50 koni nendiro, mukaha pakati pepamusoro nepasi mahwendefa akaiswa pa 0.1 mm, tembiricha yekuyera yaive 25°C, uye shear rate range yaive 0.1 kusvika 100 s-1.

Strain scanning (kutemerwa kweiyo linear viscoelastic region): Shandisa PP50 ndiro kuyera linear viscoelastic dunhu uye modulus shanduko mutemo weKGM/HPMC mukomboni mhinduro, isa nzvimbo kusvika 1.000 mm, yakatarwa frequency kusvika 1Hz, uye kuyerwa kwekushisa kusvika 25°C. The strain range i 0.1% ~ 100%.

Kakawanda kutsvaira: Shandisa PP50 ndiro kuyera modulus shanduko uye frequency kutsamira kweiyo KGM/HPMC musanganiswa mhinduro. The spacing is set to 1.000 mm, the strain is 1%, tembiricha yekuyera ndeye 25°C, uye frequency renji ndeye 0.1-100 Hz.

Temperature scanning: Iyo modulus uye kutsamira kwayo tembiricha yeKGM/HPMC komputa mhinduro yakayerwa uchishandisa PP50 ndiro, nzvimbo yacho yakaiswa ku1.000 mm, iyo yakagadziriswa frequency yaive 1 Hz, deformation yaive 1%, uye tembiricha yaibva pa25. kusvika ku90°C.

2. Migumisiro uye Analysis

2.1 Flow curve analysis yeKGM/HPMC compound system

Viscosity versus shear rate curves yeKGM/HPMC mhinduro dzine mareshiyo akasiyana ekubatanidza pazvikamu zvakasiyana. Fluids iyo viscosity ibasa remutsetse weshear rate inodaidzwa kuti Newtonian fluid, zvikasadaro inodaidzwa kunzi non-Newtonian fluids. Inogona kuonekwa kubva kune curve kuti viscosity yeKGM solution uye KGM / HPMC compound solution inoderera nekuwedzera kweshear rate; iyo yakakwira iyo KGM yemukati, yakakwira system misa chikamu, uye zvakanyanya kujeka kutetepa kweshear chiitiko chemhinduro. Izvi zvinoratidza kuti KGM neKGM/HPMC compound system haisi yeNewtonian fluid, uye rudzi rwemhando yeKGM/HPMC compound system inonyanya kutariswa neKGM.

Kubva painoyerera indekisi uye viscosity coefficient yeKGM/HPMC mhinduro dzine zvidimbu zvakasiyana-siyana uye mareshiyo emukomboni akasiyana, zvinogona kuonekwa kuti n values ​​dzeKGM, HPMC neKGM/HPMC compound masisitimu ese ari pasi pe1, zvichiratidza kuti mhinduro zvese pseudoplastic fluid. Kune iyo KGM / HPMC yemubatanidzwa system, kuwedzera kwechikamu chechikamu cheiyo system kuchakonzera kupindirana uye kumwe kupindirana pakati peHPMC neKGM molecular cheni mumhinduro, izvo zvinozoderedza kufamba kwemaketani emamorekuru, nekudaro kuderedza n kukosha kwe. hurongwa. Panguva imwecheteyo, nekuwedzera kwezvinhu zveKGM, kuwirirana pakati peKGM molecular chain muKGM / HPMC system inowedzerwa, nokudaro kuderedza kufamba kwayo uye zvichiita kuti kuderera kwen n value. Kusiyana neizvi, kukosha kweK kweKGM/HPMC komputa mhinduro kunowedzera kuenderera nekuwedzera kwechikamu chemhinduro uye KGM yemukati, iyo inonyanya kukonzerwa nekuwedzera kweiyo system misa chikamu uye KGM yemukati, izvo zvese zvinowedzera zvirimo. hydrophilic mapoka muhurongwa. , kuwedzera kupindirana kwema molecular mukati mecheni ye molecular uye pakati pemaketani, nekudaro ichiwedzera hydrodynamic radius yemorekuru, zvichiita kuti isanyanya kutarisana pasi pekuita kwekunze kweshear simba uye kuwedzera viscosity.

Iko kukosha kweiyo zero-shear viscosity yeKGM/HPMC kompani system inogona kuverengerwa zvinoenderana nepamusoro logarithmic summation musimboti, uye kukosha kwayo kwekuyedza kunogona kuwanikwa neCarren inokodzera kuwedzererwa kweiyo viscosity-shear rate curve. Kuenzanisa kukosha kwakafanotaurwa kwezero-shear viscosity yeKGM / HPMC yekomboni system ine zvikamu zvakasiyana-siyana zvehuwandu uye zvakasiyana-siyana zvinosanganiswa nehuwandu hwekuedza, zvinogona kuonekwa kuti kukosha kweiyo zero-shear viscosity yeKGM / HPMC. mhinduro idiki pane theoretical value. Izvi zvakaratidza kuti musangano mutsva une dense chimiro chakaumbwa muhurongwa hwakaoma hweKGM neHPMC. Zvidzidzo zviripo zvakaratidza kuti iyo isina kuisirwa mannose units paKGM molecular chain inogona kudyidzana nemapoka ehydrophobic paHPMC molecular chain kuumba isina kusimba muchinjiko-yakabatana hydrophobic association region. Zvinofungidzirwa kuti mutsva wegungano chimiro chine dense chimiro chinonyanya kuumbwa kuburikidza nekusangana kwehydrophobic. Kana chiyero cheKGM chakaderera (HPMC> 50%), kukosha chaiko kwezero-shear viscosity yeKGM/HPMC system yakaderera pane iyo theoretical kukosha, izvo zvinoratidza kuti pazasi KGM zvirimo, mamwe mamorekuru anotora chikamu mune denser nyowani. chimiro. Mukuumbwa kwe, zero-shear viscosity yegadziriro inowedzera kuderedzwa.

2.2 Ongororo yemhando yekutsvaira macurves eKGM/HPMC komputa system

Kubva pahukama curves ye modulus uye shear strain yeKGM/HPMC mhinduro dzine akasiyana misa zvikamu uye akasiyana ekubatanidza mareshiyo, zvinogona kuoneka kuti kana shear dhiri riri pasi pegumi muzana, iyo G.'uye G″yecompound system haina kuwedzera neshear strain. Zvisinei, inoratidza kuti mukati meiyi shear strain range, iyo komputa system inogona kupindura kune kunze kwekunze kuburikidza nekuchinja kweiyo molecular chain conformation, uye chimiro chekomboni system haina kukuvara. Kana shear strain iri> 10%, iyo yekunze Pasi pekuita kweshear simba, iyo disentanglement kumhanya kwema molecular cheni mune yakaoma system yakakura kupfuura entanglement kumhanya, G.'uye G″tanga kuderera, uye sisitimu inopinda munzvimbo isina mutsara viscoelastic. Naizvozvo, mune inotevera dynamic frequency bvunzo, iyo shear strain parameter yakasarudzwa se1% yekuyedza.

2.3 Frequency sweep curve analysis yeKGM/HPMC compound system

Kusiyanisa macurves ekuchengetedza modulus uye kurasikirwa modulus ine frequency yeKGM/HPMC mhinduro dzine akasiyana ekubatanidza mareshiyo pasi pezvikamu zvakasiyana siyana. Iyo yekuchengetedza modulus G' inomiririra simba rinogona kudzoserwa mushure mekuchengetwa kwenguva pfupi muyedzo, uye iyo yekurasikirwa modulus G "inoreva simba rinodiwa pakuyerera kwekutanga, inova kurasikirwa kusingadzoreki uye pakupedzisira inoshandurwa kuita shear kupisa. Zvinogona kuoneka kuti, ne Sezvo iyo oscillation frequency inowedzera, iyo yekurasikirwa modulus G″inogara yakakura kupfuura modulus yekuchengetedza G', kuratidza maitiro emvura. Muyedzo frequency renji, modulus yekuchengetera G' uye yekurasikirwa modulus G” inowedzera nekuwedzera kweiyo oscillation frequency. Izvi zvinonyanya kukonzerwa nekuti nekuwedzera kweiyo oscillation frequency, iyo molecular chain segments mune system haina nguva yekudzoka kune deformation munguva pfupi Iyo yapfuura mamiriro, zvichiratidza chiitiko chekuti simba rakawanda rinogona kuchengetwa. mukuru G') kana kuti inoda kurasika (G″).

Nekuwedzera kweiyo oscillation frequency, iyo yekuchengetedza modulus yehurongwa inodonha kamwe kamwe, uye nekuwedzera kwechikamu chemazana uye KGM yemukati yehurongwa, iyo frequency point yekudonha kamwe kamwe inowedzera zvishoma nezvishoma. Iko kudonha kamwe kamwe kunogona kuve nekuda kwekuparadzwa kweiyo compact chimiro chakaumbwa neiyo hydrophobic kushamwaridzana pakati peKGM neHPMC muhurongwa nekuveura kwekunze. Uyezve, kuwedzera kweiyo system mass chikamu uye KGM yemukati inobatsira kuchengetedza kugadzikana kweiyo dense chimiro, uye inowedzera yekunze frequency kukosha inoparadza chimiro.

2.4 Temperature scanning curve analysis yeKGM/HPMC composite system

Kubva pamacurve ekuchengetedza modulus uye kurasikirwa modulus yeKGM/HPMC mhinduro dzine zvidimbu zvakasiyana siyana uye akasiyana ekubatanidza mareshiyo, zvinogona kuoneka kuti kana chikamu chikuru chehurongwa chiri 0.50%, iyo G.'uye G″yemushonga weHPMC hautombo chinja nekupisa. ,uye G″>G', viscosity yegadziriro inotonga; apo chikamu chikuru chinowedzera, G'yeHPMC mhinduro inotanga isina kuchinjwa uye yobva yawedzera zvakanyanya, uye G'uye G″kuyambuka kuma70°C (Iyo mharadzano yekupisa tembiricha ndiyo gel point), uye sisitimu inoumba gel panguva ino, zvichiratidza kuti HPMC igeri rinokonzerwa nemafuta. Kune mhinduro yeKGM, kana chikamu chehuwandu hwehurongwa huri 0.50% uye 0.75%, G.'uye G yegadziriro “inoratidza muitiro uri kudzikira; kana chikamu chevazhinji chikawedzera, G' neG "yemhinduro yeKGM inotanga kuderera uye yobva yawedzera zvakanyanya, izvo zvinoratidza kuti mhinduro yeKGM inoratidzira gel-sezvivakwa pazvikamu zvepamusoro uye tembiricha yakanyanya .

Nekuwedzera kwekushisa, iyo G'uye G″yeKGM/HPMC yakaoma system yakatanga kudzikira ndokuzowedzera zvakanyanya, uye G'uye G″yakaonekwa nzvimbo dzekuyambuka, uye sisitimu yakagadzira gel. Kana HPMC mamorekuru ari pakadzika tembiricha, hydrogen bonding inoitika pakati pemapoka ehydrophilic pacheni yemamorekuru uye mamorekuru emvura, uye kana tembiricha yakwira, kupisa kwakaiswa kunoparadza mabhondi ehydrogen akaumbwa pakati peHPMC nemamorekuru emvura, zvichikonzera kuumbwa kweHPMC macromolecular. maketani. Mapoka e-hydrophobic ari pamusoro akafumurwa, hydrophobic association inoitika, uye gel thermotropic inoumbwa. Kune yakaderera misa yechikamu system, yakawanda KGM yemukati inogona kugadzira gel; yehupamhi hwechikamu chechikamu system, yakawanda HPMC yemukati inogona kugadzira gel. Muchikamu chechikamu chepasi (0.50%), kuvapo kweKGM molecules kunoderedza mukana wekugadzira mabhondi ehydrogen pakati peHPMC mamorekuru, nokudaro zvichiwedzera mukana wekuonekwa kwemapoka ehydrophobic muHPMC molecules, iyo inobatsira pakuumbwa kwemajeri ethermotropic. Muchikamu chepamusoro chechikamu chechikamu, kana zvinyorwa zveKGM zvakanyanyisa, viscosity yegadziriro yakakwirira, iyo isingaiti kushamwaridzana kwehydrophobic pakati peHPMC neKGM molecules, iyo isingabatsiri pakuumbwa kwegel thermogenic.

3. Mhedziso

Mubepa rino, maitiro erheological ekomboni system yeKGM neHPMC inodzidzwa. Mhedzisiro yacho inoratidza kuti komputa system yeKGM/HPMC isiri yeNewtonian fluid, uye rudzi rwemvura yemukomboni system yeKGM/HPMC inonyanya kutsanangurwa neKGM. Kuwedzera sisitimu misa chikamu uye KGM yemukati zvese zvakadzikisira fluidity yemukomboni mhinduro uye yakawedzera viscosity yayo. Mune sol state, ma molecular cheni eKGM neHPMC anoumba denser chimiro kuburikidza ne hydrophobic kupindirana. Chimiro chiri muhurongwa chinoparadzwa nekuveura kwekunze, zvichikonzera kudonha kamwe kamwe mukuchengetedza modulus yehurongwa. Kuwedzera kwehurongwa huwandu hwechikamu uye KGM yemukati inobatsira kuchengetedza kugadzikana kweiyo dense chimiro uye kuwedzera ekunze frequency kukosha inoparadza chimiro. Kune iyo yakaderera misa yechikamu system, yakawanda KGM yemukati inobatsira pakuumbwa kwegel; yehupamhi hwechikamu chechikamu system, yakawanda HPMC yemukati inobatsira pakuumbwa kwegel.