Kudzidza paHunhu Kudzora kweHydroxypropyl Methyl Cellulose

Zvinoenderana nemamiriro azvino ekugadzirwa kweHPMC munyika yangu, izvo zvinokanganisa kunaka kwehydroxypropyl methylcellulose zvinoongororwa, uye nechikonzero ichi, maitiro ekuvandudza huwandu hwemhando yehydroxypropyl methylcellulose inokurukurwa uye kudzidza, kuitira kuti ipinde mukugadzirwa.

Mazwi akakosha:hydroxypropyl methylcellulose; kunaka; control; research

Hydroxypropyl methylcellulose (HPMC) is non-ionic water-soluble cellulose yakasanganiswa ether yakagadzirwa nedonje, huni, uye etherified nepropylene oxide uye methyl chloride mushure mekuputika kwealkali. Cellulose yakasanganiswa ether is The modified derivative of single substituent ether ine zvinhu zviri nani zvakasarudzika pane yepakutanga monoether, uye inogona kuridza kuita kwe cellulose ether zvakanyanya uye zvakakwana. Pakati peether dzakawanda dzakasanganiswa, hydroxypropyl methylcellulose ndiyo inonyanya kukosha. Nzira yekugadzirira ndeyekuwedzera propylene oxide kune alkaline cellulose. Industrial HPMC inogona kutsanangurwa sechigadzirwa chepasirese. Dhigirii rekutsiviwa kweboka remethyl (DS kukosha) ndeye 1.3 kusvika 2.2, uye molar substitution degree yehydroxypropyl ndeye 0.1 kusvika 0.8. Zvinogona kuoneka kubva pane iri pamusoro data kuti zvirimo uye zvivakwa zvemethyl uye hydroxypropyl muHPMC zvakasiyana, zvichikonzera yekupedzisira chigadzirwa viscosity uye Musiyano mukufanana unotungamira kukuchinja kwemhando yezvigadzirwa zvakapedzwa zveakasiyana mabhizinesi ekugadzira.

Hydroxypropyl methylcellulose inogadzira zvigadzirwa zveether kuburikidza nekuita kwemakemikari, ayo ane shanduko huru mukuumbwa kwayo, chimiro uye zvivakwa, kunyanya kunyungudika kweselulosi, iyo inogona kusiana zvichienderana nerudzi uye huwandu hwemapoka ealkyl akaunzwa. Wana zvinonyunguduka mumvura, dilute alkali solution, polar solvents (senge ethanol, propanol) uye non-polar organic solvents (senge benzene, ether), iyo inowedzera zvikuru marudzi uye mashandisirwo ezvikamu zve cellulose derivatives .

1. Mhedzisiro yehydroxypropyl methylcellulose alkalization process pamhando

Iyo alkalization maitiro inhanho yekutanga mukuita nhanho yekugadzirwa kweHPMC, uye iri zvakare rimwe rematanho akanyanya kukosha. Hunhu hwemukati hwezvigadzirwa zveHPMC hunotemerwa zvakanyanya neiyo alkalization maitiro, kwete etherification maitiro, nekuti iyo alkalization mhedzisiro inokanganisa mhedzisiro ye etherification.

Hydroxypropyl methylcellulose inodyidzana nealkaline mhinduro kuumba alkali cellulose, iyo inoshanda zvakanyanya. Mune etherification reaction, maitiro makuru eetherification agent kune kuzvimba, kupinda, uye etherification ye cellulose uye The rate of side reactions, kufanana kwekuita uye maitiro echigadzirwa chekupedzisira zvese zvine chekuita nekuumbwa uye kuumbwa kwe. alkali cellulose, saka chimiro nemakemikari ealkali cellulose zvinhu zvakakosha zvekutsvagisa mukugadzirwa kwe cellulose ether.

2. Mhedzisiro yekushisa pamhando yehydroxypropyl methylcellulose

Mune kumwe kuungana kweKOH aqueous solution, iyo adsorption chiyero uye kuzvimba dhigirii rehydroxypropyl methylcellulose kune alkali inowedzera nekudzikira kwekuita tembiricha. Semuenzaniso, kubuda kwealkali cellulose kunosiyana nekuwanda kweKOH: 15%, 8% pagumi.°C, uye 4.2% pa5°C. Iyo nzira yemaitiro aya ndeyekuti kuumbwa kwealkali cellulose ndeye exothermic reaction process. Sezvo kutonhora kuchikwira, adsorption ye hydroxypropyl methylcellulose pane alkali Iyo yakawanda inoderedzwa, asi iyo hydrolysis reaction ye alkali cellulose inowedzera zvakanyanya, iyo isingabatsiri pakuumbwa kwealkali cellulose. Zvinogona kuoneka kubva pamusoro apa kuti kudzikisa tembiricha yealkalization kunobatsira kugadzirwa kwealkali cellulose uye inhibits maitiro ehydrolysis.

3. Mhedzisiro yezvinowedzera pahutano hwehydroxypropyl methylcellulose

Mune cellulose-KOH-mvura system, iyo inowedzera-munyu une simba guru pakuumbwa kwealkali cellulose. Kana kusanganiswa kweKOH mhinduro kwakadzikira kupfuura 13%, adsorption ye cellulose kune alkali haina kukanganiswa nekuwedzera kwe potassium chloride munyu. Kana iyo yakasanganiswa yelye solution yakakwira kupfuura 13%, mushure mekuwedzera potassium chloride, iyo inooneka adsorption ye cellulose kune alkali. Kuwedzerwa kwemunyu kazhinji kusingafadzi kune alkalization uye kuzvimba kweselulosi, asi munyu unogona kuvharidzira hydrolysis uye kugadzirisa hurongwa Mvura yemahara inovandudza mhedzisiro yealkalization uye etherification.

4. Kufuridzirwa kwemaitiro ekugadzirwa kwehutano hwehydroxypropyl methylcellulose

Parizvino, mabhizinesi ekugadzira hydroxypropyl methylcellulose munyika yangu anonyanya kutora maitiro ekugadzira nzira yekunyungudutsa. Iyo yekugadzirira uye etherification maitiro ealkali cellulose ese anoitwa mune inert organic solvent, saka iyo mbishi yakacheneswa donje inoda kupepetwa kuti iwane yakakura Surface nzvimbo uye reactivity kuve nechokwadi chemhando yechigadzirwa chakapedzwa.

Wedzera iyo pulverized cellulose, organic solvent uye alkali solution mureactor, uye shandisa ine simba mechanicha inobvongodza pane imwe tembiricha uye nguva kuwana alkali cellulose ine yunifomu alkalization uye kushomeka kuderera. Organic dilution solvents (isopropanol, toluene, etc.) ine imwe inertness, iyo inoita kuti hydroxypropyl methylcellulose ibudise kupisa kweyunifomu panguva yekuumbwa, ichiratidza kufambira mberi kwekuburitsa, uku ichideredza hydrolysis reaction yealkali cellulose kune rumwe rutivi Kuti uwane yakakwirira- quality alkali cellulose, kazhinji chiyero chelye inoshandiswa mune iyi link inokwira se50%.

Mushure mekunge cellulose yakanyikwa mulye, yakazvimba zvizere uye zvakaenzana alkali cellulose inowanikwa. Iyo lye osmotically inozvimba cellulose zvirinani, ichiisa hwaro hwakanaka hwekuzotevera etherification reaction. Typical diluents kunyanya zvinosanganisira isopropanol, acetone, toluene, etc. Solubility ye lye, mhando ye diluent uye inobvongodza mamiriro ezvinhu ndizvo zvikuru zvinokanganisa kuumbwa alkali cellulose. Iyo yepamusoro uye yakadzika mitsara inoumbwa kana ichisanganiswa. Iyo yepamusoro yekumusoro inoumbwa ne isopropanol nemvura, uye yakadzika pasi inoumbwa nealkali uye shoma isopropanol. Iyo cellulose yakaparadzirwa muhurongwa inonyatso sangana neyepamusoro uye yepasi mvura yakaturikidzana pasi pemakanika inomutsa. Iyo alkali muhurongwa Huwandu hwemvura hunochinja kusvika cellulose yaumbwa.

Seyakajairwa cellulose isiri-ionic yakasanganiswa ether, zviri mukati me hydroxypropyl methylcellulose mapoka ari pamaketani akasiyana macromolecular, kureva, chiyero chekugovera chemethyl uye hydroxypropyl mapoka akasiyana paC yega yega glucose mhete. Iine kupararira kukuru uye kusagadzikana, zvichiita kuti zvive zvakaoma kuvimbisa kugadzikana kwehutano hwechigadzirwa.