Matambudziko mukushandiswa kweHydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC) ipolymer inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, kusanganisira maindasitiri emishonga, chikafu, uye cosmetic, nekuda kwehunhu hwayo hwakasiyana, hwakadai sekunyungudika kwakanyanya, kugadzikana kwekupisa, uye kugona kugadzira firimu. Nekudaro, kune akati wandei matambudziko ane chekuita nekushandiswa kweHPMC, izvo zvinogona kukanganisa kuita kwayo uye kushanda kwayo. Muchikamu chino, tichakurukura mamwe ematambudziko akajairika mukushandiswa kweHPMC uye nemhinduro dzadzo.

1. Kusaenderana viscosity

Imwe yematambudziko akajairika mukushandiswa kweHPMC ndeye isingaenderane viscosity yemhinduro. HPMC inowanikwa mumagiredhi akasiyana, uye viscosity yegiredhi rega rega inogona kusiyana zvichienderana nezvinhu zvakaita sedhigirii rekutsiva, huremu hwemamorekuru, uye saizi yechikamu. Nekuda kweizvozvo, zvinogona kuve zvinonetsa kuwana inowirirana viscosity yeHPMC mhinduro.

Solution: Kukunda dambudziko iri, zvakakosha kushandisa HPMC yegiredhi rinoenderana uye mhando. Vagadziri vanofanirwa kupa ruzivo rwakadzama nezvezvivakwa zvezvigadzirwa zvavo zveHPMC, senge viscosity range, particle size distribution, uye degree of substitution, kubatsira vashandisi kusarudza giredhi rakakodzera rekushandisa kwavo chaiko. Pamusoro pezvo, zvinokurudzirwa kushandisa viscometer kuyera viscosity yeHPMC mhinduro panguva yekugadzirira maitiro kuti ive nechokwadi chekuenderana.

2. Murombo solubility

Rimwe dambudziko rakabatana neHPMC ikushaya kunyungudika. HPMC ipolmer inonyungudika nemvura, asi kunyungudika kwayo kunogona kukanganiswa nezvinhu zvakaita sepH, tembiricha, uye kuvapo kwezvimwe zvinowedzera.

Solution: Kuvandudza kunyungudika kweHPMC, zvinokurudzirwa kushandisa yemhando yepamusoro HPMC chigadzirwa chine yakaderera dhigirii yekutsiva. Izvi zvichawedzera huwandu hweanowanikwa hydroxyl mapoka pane polymer cheni, iyo inovandudza kunyungudika kwayo. Pamusoro pezvo, zvakakosha kushandisa solvent yakakodzera uye kuona kuti iri patembiricha chaiyo uye pH. Kana kunyungudika kweHPMC kuchiri kwakashata, zvingave zvakakodzera kushandisa surfactant kana imwe solubilizing agent.

3. Kusapindirana nezvimwe excipients

HPMC inowanzo shandiswa pamwe chete nemamwe maexcipients kuvandudza mashandiro uye zvimiro zvechigadzirwa chekupedzisira. Nekudaro, zvimwe zvekushandisa zvinogona kunge zvisingaenderane neHPMC, zvichitungamira kumatambudziko akadai sekuparadzaniswa kwechikamu, kuumbwa kwegel, kana shanduko mune viscosity.

Solution: Kuti udzivise kusapindirana nyaya, zvakakosha kuti uedze kuenderana kweHPMC nemamwe maexcipients usati washandisa. Izvi zvinogona kuitwa nekugadzirira diki-mwero kuumbwa uye kucherechedza chero shanduko muchitarisiko, viscosity, kana zvimwe zvivakwa. Kana kusapindirana kuchionekwa, zvingave zvakakosha kugadzirisa kuumbwa kana kushandisa imwe excipient.

4. Kutadza kugadzira firimu

HPMC inowanzo shandiswa sechinhu chinonamira mahwendefa nemakapisi kuti avandudze chitarisiko chavo, kugadzikana, uye kumedza. Nekudaro, iyo firimu-kugadzira kugona kweHPMC inogona kukanganiswa nezvinhu zvakaita sehunyoro