Hydroxypropyl methylcellulose inoshandisa mumapiritsi

Hydroxypropyl methylcellulose (HPMC) chinhu chinowanzo shandiswa mumishonga, kusanganisira mapiritsi. HPMC ndeye cellulose-based polymer inonyungudika mumvura uye ine zvakasiyana-siyana zvezvivakwa zvinoita kuti zvive zvakakosha mukugadzirwa kwehwendefa. Ichi chinyorwa chichakurukura zvivakwa zveHPMC uye mashandisiro ayo akasiyana mukugadzira piritsi.

Properties of HPMC:

HPMC inonzi hydrophilic polima inogona kushandiswa sebhainda, thickener, stabilizer, uye emulsifier. Iine huremu hwema molecular uye huwandu hwepamusoro hwekutsiva (DS), iyo inokanganisa kunyungudika kwayo uye viscosity. HPMC inogona kunyungudika mumvura kana mudoro, asi haina kunyungudika mune zvakawanda organic solvents. Iyo zvakare isiri-chepfu, isingatsamwise, uye isiri-allergenic, zvichiita kuti ive sarudzo yakanaka yekushandiswa kwemishonga.

Kushandiswa kweHPMC mumapiritsi:

1. Binder:

HPMC inowanzoshandiswa sebhainda mukugadzirwa kwehwendefa. Inowedzerwa pahwendefa granules kuti ibate pamwe chete uye kudzivirira kuti irege kuparara. HPMC inogona kushandiswa yoga kana pamwe chete nemamwe mabhaidha, akadai se microcrystalline cellulose (MCC), kunatsiridza kuoma kwehwendefa uye friability.

2. Disintegrant:

HPMC inogona zvakare kushandiswa se disintegrant mukugadzira piritsi. Disintegrants anowedzerwa pamapiritsi kuti avabatsire kubvarura uye kunyungudika nekukurumidza mudumbu remukati. HPMC inoshanda se disintegrant nekuzvimba mumvura uye kugadzira migero yekuti mvura ipinde muhwendefa. Izvi zvinobatsira kuparadzanisa piritsi uye kusunungura chinhu chinoshanda.

3. Kuburitswa kunodzorwa:

HPMC inoshandiswa mukudzorwa-kuburitsa piritsi maumbirwo ekugadzirisa kuburitswa kwechinhu chinoshanda. HPMC inoumba gel layer yakatenderedza piritsi, iyo inodzora kuburitswa kweiyo inoshanda ingredient. Ukobvu hwejeli layer hunogona kudzorwa nekushandura DS yeHPMC, iyo inokanganisa viscosity uye kunyungudika kwepolymer.

4. Film-coating:

HPMC inoshandiswawo semugadziri wefirimu-yekuputira mukugadzirwa kwehwendefa. Firimu-kupfekedza maitiro ekuisa yakatetepa yepolymer pahwendefa repamusoro kuti ivandudze kutaridzika kwayo, kuidzivirira kubva kune hunyoro, uye kuvhara kuravira kwayo. HPMC inogona kushandiswa yoga kana pamwe chete nemamwe mafirimu-coating agents, akadai se polyethylene glycol (PEG), kuti avandudze firimu-kuumba maitiro ekuputira.

5. Suspension agent:

HPMC inoshandiswawo seyakamiswa mumiriri mune yemvura magadzirirwo. Inogona kushandiswa kumisa zvisinganyunguriki zvimedu mumvura kugadzira kumira kwakagadzikana. HPMC inoshanda nekugadzira chidziviriro chakatenderedza zvimedu, ichidzidzivirira kubva mukusangana uye kugadzika pasi pemudziyo.

Mhedziso:

Hydroxypropyl methylcellulose i polymer inoshanda zvakasiyana-siyana ine zvakasiyana-siyana zvekushandisa mukugadzirwa kwehwendefa. Inogona kushandiswa sebhainda, disintegrant, controlled-release agent, film-coating agent, uye suspension agent. Iyo isiri-chepfu, isingatsamwire, uye isiri-allergenic zvimiro inoita kuti ive sarudzo yakanaka yekushandiswa kwemishonga. Zvimiro zveHPMC zvinogona kugadzirwa nekushandura dhigirii rekutsiva, zvichiita kuti ive polymer inochinjika inogona kushandiswa mumhando dzakasiyana dzemahwendefa.