Hydroxypropyl methylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana anosanganisira mishonga, chikafu uye kuvaka. Chimwe chezvinhu zvayo zvakakosha kuchengetedza mvura, iyo inoita basa rakakosha pakuona kushanda kwayo mumashandisirwo akasiyana.
1 Nhanganyaya:
Hydroxypropylmethylcellulose (HPMC) is cellulose-based polymer inotorwa kubva kune yakasikwa cellulose. Iyo yakakwezva kutarisisa kwayo yakanakisa firimu-kugadzira kugona, inonamira zvimiro uye, zvakanyanya kukosha, inochengetedza mvura. Iyo yekubata-mvura simba yeHPMC ndiyo yakakosha parameter mumashandisirwo akadai sezvivakwa zvekuvaka, maumbirwo emishonga, uye zvigadzirwa zvekudya.
2. Kukosha kwekuchengetedza mvura muHPMC:
Kunzwisisa kuchengetedza kwemvura zvivakwa zveHPMC kwakakosha kukwenenzvera kuita kwayo mumashandisirwo akasiyana siyana. Muzvivakwa zvekuvaka, inovimbisa kunamatira kwakakodzera uye kushanda kwemateki uye plasters. Mumishonga yemishonga, inokanganisa kuburitswa kwemishonga, uye muzvikafu, inokanganisa magadzirirwo uye hupenyu hwesherufu.
3. Zvinhu zvinokanganisa kuchengetwa kwemvura:
Zvinhu zvakati wandei zvinokanganisa simba rekubata mvura reHPMC, kusanganisira huremu hwemamorekuru, dhigirii rekutsiva, tembiricha, uye kuisa pfungwa. Kunzwisisa zvinhu izvi kwakakosha pakugadzira zviedzo zvinonyatsoratidza mamiriro epasirese.
4. Nzira dzakajairika dzekuyedza kuchengetedza mvura:
Gravimetric nzira:
Weresa sampuli dzeHPMC usati wanyudzwa mumvura uye mushure mekunyudzwa.
Verenga huwandu hwekuchengetedza mvura uchishandisa fomura inotevera: Mwero wekuchengeta mvura (%) = [(Huremu mushure mekunyura - Huremu hwekutanga) / Huremu hwekutanga] x 100.
Kuzvimba index:
Kuwedzera kwehuwandu hweHPMC mushure mekunyudzwa mumvura kwakayerwa.
Kuzvimba indekisi (%) = [(vhoriyamu mushure mekunyudzwa - vhoriyamu yekutanga)/vhoriyamu yekutanga] x 100.
Centrifugation nzira:
Centrifuge iyo HPMC-mvura musanganiswa uye kuyera huwandu hwemvura yakachengetwa.
Mwero wekuchengetedza mvura (%) = (mvura yekuchengetedza simba / yekutanga mvura simba) x 100.
Nuclear Magnetic Resonance (NMR):
Kudyidzana pakati peHPMC nemamorekuru emvura kwakadzidzwa pachishandiswa NMR spectroscopy.
Wana ruzivo rwekuchinja kwema molecular-level muHPMC panguva yekutora mvura.
5. Matanho ekuedza:
Muenzaniso Kugadzirira:
Ita shuwa kuti HPMC samples inomiririra iyo yakanangwa application.
Kudzora zvinhu zvakaita senge saizi uye mwando.
Kuyera uremu:
Nyatsoyera kuyerwa HPMC sampuli.
Nyura muenzaniso mumvura kwenguva yakatarwa.
Sample yakaomeswa uye huremu hwakayerwa zvakare.
Verenga kuchengetwa kwemvura.
Kuwedzera indekisi kuyerwa:
Edza huwandu hwekutanga hweHPMC.
Nyura sampuli mumvura uye kuyera vhoriyamu yekupedzisira.
Verenga indekisi yekuwedzera.
Centrifuge test:
Sanganisa HPMC nemvura uye bvumira kuenzana.
Centrifuge musanganiswa uye kuyera huwandu hwemvura yakachengetwa.
Verenga kuchengetwa kwemvura.
NMR ongororo:
Kugadzirira kweHPMC-mvura samples yeNMR kuongororwa.
Ongorora kuchinja kwemakemikari kuchinja uye peak intensity.
Kubatanidza NMR data nekuchengetedza mvura zvivakwa.
6. Kuongorora uye kududzira data:
Tsanangura mibairo yakawanikwa nenzira yega yega, uchifunga nezvezvinodiwa zvekushandisa. Enzanisa data kubva munzira dzakasiyana kuti uwane kunzwisisa kwakadzama kwemaitiro ekuchengetedza mvura eHPMC.
7. Matambudziko nekufunga:
Kurukurai zvingangonetsa mukuyedza kuchengetwa kwemvura, sekusiyana kwemasampuli eHPMC, mamiriro ekunze, uye kudiwa kwekumisikidzwa.
8. Mhedziso:
Izvo zvakakosha zvakawanikwa zvakapfupikiswa uye kukosha kwekunzwisisa kuchengetedza kwemvura zvivakwa zveHPMC zvekushandisa kwayo kwakabudirira mumaindasitiri akasiyana kunosimbiswa.
9.Ramangwana tarisiro:
Kufambira mberi kungangoitika munzira dzekuyedza uye matekiniki anokurukurwa kuwedzera kunzwisisa kwedu kwekuchengetedza mvura zvivakwa zveHPMC.
Nguva yekutumira: Zvita-11-2023